SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k5z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 6 VAL A 344
VAL A 306
ILE A 328
ARG A 390
 None
 1.03A 1iepA-3k5zA:
undetectable		 1iepA-3k5zA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 7 MET A 471
ARG A 518
TRP A 534
PHE A 531
 None
 1.21A 1p6kA-3k5zA:
undetectable
1p6kB-3k5zA:
undetectable		 1p6kA-3k5zA:
23.63
1p6kB-3k5zA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 7 TRP A 534
PHE A 531
MET A 471
ARG A 518
 None
 1.22A 1p6kA-3k5zA:
undetectable
1p6kB-3k5zA:
undetectable		 1p6kA-3k5zA:
23.63
1p6kB-3k5zA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		5 / 12 THR A 278
VAL A 347
ALA A 317
CYH A 319
VAL A 365
 None
 1.14A 2g72A-3k5zA:
undetectable		 2g72A-3k5zA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		5 / 12 THR A 278
VAL A 347
ALA A 317
CYH A 319
VAL A 365
 None
 1.16A 2g72B-3k5zA:
undetectable		 2g72B-3k5zA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 5 LEU A 246
GLN A 205
LEU A 207
GLU A 208
 None
None
None
A  B   9 ( 4.4A)
 0.85A 3h5gA-3k5zA:
undetectable
3h5gB-3k5zA:
undetectable		 3h5gA-3k5zA:
6.91
3h5gB-3k5zA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 7 LEU A 207
PRO A 169
SER A 172
GLY A 192
 None
 0.98A 3hcnA-3k5zA:
undetectable		 3hcnA-3k5zA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 7 LEU A 207
PRO A 169
SER A 172
GLY A 192
 None
 1.04A 3hcrB-3k5zA:
undetectable		 3hcrB-3k5zA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 7 VAL A 344
VAL A 306
ILE A 328
ARG A 390
 None
 1.07A 3mssB-3k5zA:
undetectable		 3mssB-3k5zA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		5 / 12 LEU A 337
LEU A 389
ARG A 392
ALA A 375
ASP A 345
 None
 1.17A 4aqlA-3k5zA:
undetectable		 4aqlA-3k5zA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C39_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 7 MET A 471
ARG A 518
TRP A 534
PHE A 531
 None
 1.27A 4c39A-3k5zA:
undetectable
4c39B-3k5zA:
undetectable		 4c39A-3k5zA:
23.63
4c39B-3k5zA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 6 ALA A 198
LEU A 246
VAL A 247
ASP A 233
 None
 1.00A 4g24A-3k5zA:
2.7		 4g24A-3k5zA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		3 / 3 CYH A 405
ASN A 403
LYS A 437
 None
 1.38A 4k50A-3k5zA:
0.7		 4k50A-3k5zA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		5 / 11 LEU A 535
LEU A 507
GLU A 560
ALA A 563
LEU A 562
 None
 0.96A 4wg0B-3k5zA:
undetectable
4wg0C-3k5zA:
undetectable
4wg0D-3k5zA:
undetectable		 4wg0B-3k5zA:
3.37
4wg0C-3k5zA:
3.37
4wg0D-3k5zA:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		5 / 11 LEU A 535
LEU A 507
GLU A 560
ALA A 563
LEU A 562
 None
 0.95A 4wg0D-3k5zA:
undetectable
4wg0E-3k5zA:
undetectable
4wg0F-3k5zA:
undetectable		 4wg0D-3k5zA:
3.37
4wg0E-3k5zA:
3.37
4wg0F-3k5zA:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		5 / 11 LEU A 535
LEU A 507
GLU A 560
ALA A 563
LEU A 562
 None
 0.97A 4wg0F-3k5zA:
undetectable
4wg0G-3k5zA:
undetectable
4wg0H-3k5zA:
undetectable		 4wg0F-3k5zA:
3.37
4wg0G-3k5zA:
3.37
4wg0H-3k5zA:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		5 / 11 LEU A 535
LEU A 507
GLU A 560
ALA A 563
LEU A 562
 None
 1.04A 4wg0J-3k5zA:
undetectable
4wg0K-3k5zA:
undetectable
4wg0L-3k5zA:
undetectable		 4wg0J-3k5zA:
3.37
4wg0K-3k5zA:
3.37
4wg0L-3k5zA:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 7 TRP A 534
PHE A 531
MET A 471
ARG A 518
 None
 1.37A 5ad6A-3k5zA:
undetectable
5ad6B-3k5zA:
undetectable		 5ad6A-3k5zA:
23.63
5ad6B-3k5zA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD7_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 6 MET A 471
ARG A 518
TRP A 534
PHE A 531
 None
 1.35A 5ad7A-3k5zA:
0.0
5ad7B-3k5zA:
0.0		 5ad7A-3k5zA:
23.63
5ad7B-3k5zA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADB_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 6 MET A 471
ARG A 518
TRP A 534
PHE A 531
 None
 1.46A 5adbA-3k5zA:
0.0
5adbB-3k5zA:
0.0		 5adbA-3k5zA:
23.63
5adbB-3k5zA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADG_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 7 TRP A 534
PHE A 531
MET A 471
ARG A 518
 None
 1.33A 5adgA-3k5zA:
undetectable
5adgB-3k5zA:
undetectable		 5adgA-3k5zA:
22.98
5adgB-3k5zA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADI_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 6 TRP A 534
PHE A 531
MET A 471
ARG A 518
 None
 1.34A 5adiA-3k5zA:
0.0
5adiB-3k5zA:
0.0		 5adiA-3k5zA:
22.98
5adiB-3k5zA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FW0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 7 TRP A 534
PHE A 531
MET A 471
ARG A 518
 None
 1.32A 5fw0A-3k5zA:
undetectable
5fw0B-3k5zA:
undetectable		 5fw0A-3k5zA:
23.63
5fw0B-3k5zA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 6 VAL A 211
LEU A 185
CYH A 204
LEU A 194
 None
None
A  B   9 ( 4.1A)
None
 1.23A 5hrqB-3k5zA:
undetectable
5hrqI-3k5zA:
undetectable
5hrqJ-3k5zA:
undetectable		 5hrqB-3k5zA:
6.30
5hrqI-3k5zA:
6.07
5hrqJ-3k5zA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		3 / 3 ILE A 421
ILE A 435
MET A 398
 None
 0.70A 5i9yA-3k5zA:
undetectable		 5i9yA-3k5zA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		3 / 3 VAL A 347
GLN A 329
CYH A 319
 None
 0.71A 5icxC-3k5zA:
undetectable
5icxF-3k5zA:
undetectable		 5icxC-3k5zA:
20.64
5icxF-3k5zA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 6 ILE A 228
VAL A 289
VAL A 247
SER A 293
 None
 0.81A 5jwaH-3k5zA:
undetectable		 5jwaH-3k5zA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNS_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 7 TRP A 534
PHE A 531
MET A 471
ARG A 518
 None
 1.38A 5unsA-3k5zA:
undetectable
5unsB-3k5zA:
undetectable		 5unsA-3k5zA:
23.63
5unsB-3k5zA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 7 MET A 471
ARG A 518
TRP A 534
PHE A 531
 None
 1.30A 5unuA-3k5zA:
undetectable
5unuB-3k5zA:
undetectable		 5unuA-3k5zA:
23.63
5unuB-3k5zA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 7 TRP A 534
PHE A 531
MET A 471
ARG A 518
 None
 1.41A 5unuA-3k5zA:
undetectable
5unuB-3k5zA:
undetectable		 5unuA-3k5zA:
23.63
5unuB-3k5zA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 7 TRP A 534
PHE A 531
MET A 471
ARG A 518
 None
 1.34A 5unwA-3k5zA:
undetectable
5unwB-3k5zA:
undetectable		 5unwA-3k5zA:
23.63
5unwB-3k5zA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 7 MET A 471
ARG A 518
TRP A 534
PHE A 531
 None
 1.40A 5unxA-3k5zA:
undetectable
5unxB-3k5zA:
undetectable		 5unxA-3k5zA:
23.63
5unxB-3k5zA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO0_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 6 MET A 471
ARG A 518
TRP A 534
PHE A 531
 None
 1.27A 5uo0A-3k5zA:
0.0
5uo0B-3k5zA:
0.0		 5uo0A-3k5zA:
23.63
5uo0B-3k5zA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO2_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 7 MET A 471
ARG A 518
TRP A 534
PHE A 531
 None
 1.34A 5uo2A-3k5zA:
undetectable
5uo2B-3k5zA:
undetectable		 5uo2A-3k5zA:
22.98
5uo2B-3k5zA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO3_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 7 MET A 471
ARG A 518
TRP A 534
PHE A 531
 None
 1.38A 5uo3A-3k5zA:
undetectable
5uo3B-3k5zA:
undetectable		 5uo3A-3k5zA:
22.98
5uo3B-3k5zA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO3_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 7 TRP A 534
PHE A 531
MET A 471
ARG A 518
 None
 1.30A 5uo3A-3k5zA:
undetectable
5uo3B-3k5zA:
undetectable		 5uo3A-3k5zA:
22.98
5uo3B-3k5zA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO4_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 7 TRP A 534
PHE A 531
MET A 471
ARG A 518
 None
 1.33A 5uo4A-3k5zA:
undetectable
5uo4B-3k5zA:
undetectable		 5uo4A-3k5zA:
22.98
5uo4B-3k5zA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO6_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 6 MET A 471
ARG A 518
TRP A 534
PHE A 531
 None
 1.36A 5uo6A-3k5zA:
0.0
5uo6B-3k5zA:
0.0		 5uo6A-3k5zA:
22.98
5uo6B-3k5zA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO6_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 7 TRP A 534
PHE A 531
MET A 471
ARG A 518
 None
 1.31A 5uo6A-3k5zA:
undetectable
5uo6B-3k5zA:
undetectable		 5uo6A-3k5zA:
22.98
5uo6B-3k5zA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 8 MET A 471
ARG A 518
TRP A 534
PHE A 531
 None
 1.33A 5uo7A-3k5zA:
undetectable
5uo7B-3k5zA:
undetectable		 5uo7A-3k5zA:
22.98
5uo7B-3k5zA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 7 TRP A 534
PHE A 531
MET A 471
ARG A 518
 None
 1.35A 5uo7A-3k5zA:
undetectable
5uo7B-3k5zA:
undetectable		 5uo7A-3k5zA:
22.98
5uo7B-3k5zA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUI_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 7 TRP A 534
PHE A 531
MET A 471
ARG A 518
 None
 1.33A 5vuiA-3k5zA:
undetectable
5vuiB-3k5zA:
undetectable		 5vuiA-3k5zA:
23.63
5vuiB-3k5zA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV3_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 7 TRP A 534
PHE A 531
MET A 471
ARG A 518
 None
 1.32A 5vv3A-3k5zA:
undetectable
5vv3B-3k5zA:
undetectable		 5vv3A-3k5zA:
22.98
5vv3B-3k5zA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV4_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 7 TRP A 534
PHE A 531
MET A 471
ARG A 518
 None
 1.29A 5vv4A-3k5zA:
undetectable
5vv4B-3k5zA:
undetectable		 5vv4A-3k5zA:
22.98
5vv4B-3k5zA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUQ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 7 TRP A 534
PHE A 531
MET A 471
ARG A 518
 None
 1.35A 6auqA-3k5zA:
undetectable
6auqB-3k5zA:
undetectable		 6auqA-3k5zA:
11.00
6auqB-3k5zA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3k5z FEM-3 MRNA-BINDING
FACTOR 2
(Caenorhabditis
elegans) 		4 / 7 TRP A 534
PHE A 531
MET A 471
ARG A 518
 None
 1.40A 6auuA-3k5zA:
undetectable
6auuB-3k5zA:
undetectable		 6auuA-3k5zA:
11.00
6auuB-3k5zA:
11.00