SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k6g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 3k6g TELOMERIC
REPEAT-BINDING
FACTOR 2-INTERACTING
PROTEIN 1
TELOMERIC
REPEAT-BINDING
FACTOR 2
(Homo
sapiens;
Homo
sapiens) 		5 / 10 ASP A 328
LEU A 329
SER D 296
THR A 331
PHE D 292
 None
 1.46A 1rqpA-3k6gA:
undetectable		 1rqpA-3k6gA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 3k6g TELOMERIC
REPEAT-BINDING
FACTOR 2-INTERACTING
PROTEIN 1
TELOMERIC
REPEAT-BINDING
FACTOR 2
(Homo
sapiens;
Homo
sapiens) 		5 / 12 LEU A 343
LEU A 321
MET A 322
LEU A 327
LEU D 288
 None
 1.07A 2ouzA-3k6gA:
undetectable		 2ouzA-3k6gA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3k6g TELOMERIC
REPEAT-BINDING
FACTOR 2-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 317
ILE A 318
LEU A 321
GLY A 341
VAL A 332
 None
 0.92A 3rukB-3k6gA:
undetectable		 3rukB-3k6gA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3k6g TELOMERIC
REPEAT-BINDING
FACTOR 2-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 8 ASP A 357
ASP A 366
ASN A 389
GLU A 342
 None
 1.07A 4feuF-3k6gA:
undetectable		 4feuF-3k6gA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3k6g TELOMERIC
REPEAT-BINDING
FACTOR 2-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 7 ASP A 357
ASP A 366
ASN A 389
GLU A 342
 None
 1.08A 4fevF-3k6gA:
undetectable		 4fevF-3k6gA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3k6g TELOMERIC
REPEAT-BINDING
FACTOR 2-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 7 ASP A 357
ASP A 366
ASN A 389
GLU A 342
 None
 1.01A 4fexB-3k6gA:
undetectable		 4fexB-3k6gA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3k6g TELOMERIC
REPEAT-BINDING
FACTOR 2-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 8 ASP A 357
ASP A 366
ASN A 389
GLU A 342
 None
 1.04A 4gkhB-3k6gA:
undetectable		 4gkhB-3k6gA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3k6g TELOMERIC
REPEAT-BINDING
FACTOR 2-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 8 ASP A 357
ASP A 366
ASN A 389
GLU A 342
 None
 1.09A 4gkiC-3k6gA:
undetectable		 4gkiC-3k6gA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3k6g TELOMERIC
REPEAT-BINDING
FACTOR 2-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 317
ILE A 318
LEU A 321
GLY A 341
VAL A 332
 None
 0.97A 4nkvB-3k6gA:
undetectable		 4nkvB-3k6gA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3k6g TELOMERIC
REPEAT-BINDING
FACTOR 2
TELOMERIC
REPEAT-BINDING
FACTOR 2-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 5 GLU A 395
GLU A 342
THR A 346
LEU D 288
 None
 1.08A 5hm8G-3k6gA:
undetectable		 5hm8G-3k6gA:
13.98