SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k6h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 3k6h NITROREDUCTASE
FAMILY PROTEIN
(Agrobacterium
fabrum) 		4 / 8 GLU A  87
LEU A  71
ALA A  74
LEU A  75
 None
 0.67A 1hwiB-3k6hA:
4.8		 1hwiB-3k6hA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 3k6h NITROREDUCTASE
FAMILY PROTEIN
(Agrobacterium
fabrum) 		4 / 8 GLU A  87
LEU A  71
ALA A  74
LEU A  75
 None
 0.67A 1hwiD-3k6hA:
4.5		 1hwiD-3k6hA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 3k6h NITROREDUCTASE
FAMILY PROTEIN
(Agrobacterium
fabrum) 		4 / 8 GLU A  87
LEU A  71
ALA A  74
LEU A  75
 None
 0.66A 1hwiC-3k6hA:
4.6		 1hwiC-3k6hA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 3k6h NITROREDUCTASE
FAMILY PROTEIN
(Agrobacterium
fabrum) 		5 / 12 ILE A 129
ALA A 131
PRO A  27
LEU A  24
TYR A  12
 None
 1.24A 1u70A-3k6hA:
undetectable		 1u70A-3k6hA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 3k6h NITROREDUCTASE
FAMILY PROTEIN
(Agrobacterium
fabrum) 		4 / 6 ARG A  16
THR A  19
ALA A 139
PRO A 177
 FMN  A 199 (-3.1A)
None
None
None
 1.37A 2ql8A-3k6hA:
2.7
2ql8B-3k6hA:
2.4		 2ql8A-3k6hA:
24.27
2ql8B-3k6hA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 3k6h NITROREDUCTASE
FAMILY PROTEIN
(Agrobacterium
fabrum) 		5 / 8 ILE A 170
PRO A  29
SER A 172
GLY A 171
ASN A 133
 None
 1.32A 3lslA-3k6hA:
undetectable
3lslD-3k6hA:
undetectable		 3lslA-3k6hA:
21.29
3lslD-3k6hA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 3k6h NITROREDUCTASE
FAMILY PROTEIN
(Agrobacterium
fabrum) 		5 / 8 ASN A 133
ILE A 170
PRO A  29
SER A 172
GLY A 171
 None
 1.32A 3lslA-3k6hA:
undetectable
3lslD-3k6hA:
undetectable		 3lslA-3k6hA:
21.29
3lslD-3k6hA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_C_GM4C301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3k6h NITROREDUCTASE
FAMILY PROTEIN
(Agrobacterium
fabrum) 		5 / 11 VAL A  99
ALA A  96
LEU A 146
GLU A 144
THR A  91
 None
None
None
FMN  A 199 ( 4.0A)
None
 1.32A 6dk1C-3k6hA:
undetectable		 6dk1C-3k6hA:
22.36