SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k6j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE
(Caenorhabditis
elegans) 		4 / 8 HIS A  -5
ILE A 187
HIS A  -6
HIS A 173
 ZN  A 800 (-3.1A)
None
None
ZN  A 800 (-3.0A)
 0.95A 1ei6D-3k6jA:
undetectable		 1ei6D-3k6jA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE
(Caenorhabditis
elegans) 		4 / 8 GLY A 171
ALA A 200
ILE A 172
THR A 192
 None
 0.82A 1gtnP-3k6jA:
undetectable
1gtnQ-3k6jA:
undetectable		 1gtnP-3k6jA:
12.65
1gtnQ-3k6jA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE
(Caenorhabditis
elegans) 		3 / 3 HIS A  31
ASP A 371
ASN A 366
 None
 0.87A 1wg8B-3k6jA:
6.8		 1wg8B-3k6jA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE
(Caenorhabditis
elegans) 		5 / 12 PHE A 304
ILE A 247
SER A 233
ILE A 251
TYR A 229
 None
 1.20A 2efjA-3k6jA:
5.6		 2efjA-3k6jA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE
(Caenorhabditis
elegans) 		5 / 12 VAL A 214
ILE A 372
LEU A 376
VAL A 221
HIS A  -5
 PO4  A 501 (-4.0A)
None
None
None
ZN  A 800 (-3.1A)
 1.14A 2jn3A-3k6jA:
undetectable		 2jn3A-3k6jA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE
(Caenorhabditis
elegans) 		5 / 12 GLU A 287
LYS A 276
HIS A 227
MET A 272
PHE A 269
 None
 1.36A 2zj0A-3k6jA:
7.2		 2zj0A-3k6jA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE
(Caenorhabditis
elegans) 		5 / 12 GLU A 287
LYS A 276
HIS A 227
MET A 272
PHE A 269
 None
 1.41A 2zj0B-3k6jA:
3.9		 2zj0B-3k6jA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE
(Caenorhabditis
elegans) 		5 / 12 GLU A 287
LYS A 276
HIS A 227
MET A 272
PHE A 269
 None
 1.40A 2zj0C-3k6jA:
7.0		 2zj0C-3k6jA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE
(Caenorhabditis
elegans) 		4 / 5 LEU A  67
ILE A  56
ILE A 106
GLY A  47
 None
 0.63A 3bufA-3k6jA:
undetectable		 3bufA-3k6jA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE
(Caenorhabditis
elegans) 		5 / 12 GLU A 287
LYS A 276
HIS A 227
MET A 272
PHE A 269
 None
 1.39A 3ce6C-3k6jA:
3.8		 3ce6C-3k6jA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE
(Caenorhabditis
elegans) 		5 / 12 GLU A 287
LYS A 276
HIS A 227
MET A 272
PHE A 269
 None
 1.38A 3ce6D-3k6jA:
3.9		 3ce6D-3k6jA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE
(Caenorhabditis
elegans) 		6 / 12 LEU A 213
ALA A 200
VAL A 184
GLY A 148
VAL A 214
ILE A 186
 None
None
None
None
PO4  A 501 (-4.0A)
None
 1.47A 3jw2B-3k6jA:
undetectable		 3jw2B-3k6jA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE
(Caenorhabditis
elegans) 		5 / 12 GLU A 121
GLY A 148
GLY A  46
PHE A 174
ILE A  45
 None
 1.29A 3k13C-3k6jA:
2.4		 3k13C-3k6jA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE
(Caenorhabditis
elegans) 		5 / 12 PHE A  58
PHE A 174
ALA A 203
ILE A 186
ILE A 187
 None
 1.12A 3ld6A-3k6jA:
undetectable		 3ld6A-3k6jA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE
(Caenorhabditis
elegans) 		5 / 10 LEU A 213
ALA A 200
VAL A 184
GLY A 148
ILE A 186
 None
 1.00A 3nu6B-3k6jA:
undetectable		 3nu6B-3k6jA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE
(Caenorhabditis
elegans) 		4 / 7 LEU A 213
ALA A 200
VAL A 120
ILE A 186
 None
 0.77A 3wsjB-3k6jA:
undetectable		 3wsjB-3k6jA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE
(Caenorhabditis
elegans) 		3 / 3 PHE A 304
ASP A 317
ARG A 295
 None
 0.72A 4eahF-3k6jA:
undetectable		 4eahF-3k6jA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE
(Caenorhabditis
elegans) 		3 / 3 PHE A 304
ASP A 317
ARG A 295
 None
 0.71A 4eahG-3k6jA:
undetectable		 4eahG-3k6jA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE
(Caenorhabditis
elegans) 		6 / 10 ILE A  45
GLY A  46
GLY A  51
SER A  41
THR A  65
PHE A  66
 None
 1.47A 4fakA-3k6jA:
undetectable		 4fakA-3k6jA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE
(Caenorhabditis
elegans) 		4 / 7 GLY A  48
GLY A  51
ASN A 150
GLU A  78
 PO4  A 503 ( 3.8A)
None
None
None
 1.08A 4fgkB-3k6jA:
4.5		 4fgkB-3k6jA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE
(Caenorhabditis
elegans) 		6 / 12 LEU A 213
ALA A 200
VAL A 184
GLY A 148
VAL A 214
ILE A 186
 None
None
None
None
PO4  A 501 (-4.0A)
None
 1.46A 4jecA-3k6jA:
undetectable		 4jecA-3k6jA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA408_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE
(Caenorhabditis
elegans) 		4 / 6 THR A 393
PRO A 381
PHE A 254
ARG A   9
 None
 1.37A 4kf9A-3k6jA:
undetectable		 4kf9A-3k6jA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE
(Caenorhabditis
elegans) 		3 / 3 ASP A 165
LEU A  24
ARG A  28
 None
 0.94A 5e8qA-3k6jA:
undetectable		 5e8qA-3k6jA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE
(Caenorhabditis
elegans) 		5 / 8 ILE A  97
TYR A  83
GLY A  59
THR A  65
LEU A  67
 None
 1.46A 5esfA-3k6jA:
undetectable		 5esfA-3k6jA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE
(Caenorhabditis
elegans) 		5 / 11 ARG A   9
PHE A 390
VAL A 352
ILE A 372
ILE A 251
 None
 1.14A 5hw8A-3k6jA:
undetectable
5hw8D-3k6jA:
undetectable		 5hw8A-3k6jA:
16.58
5hw8D-3k6jA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE
(Caenorhabditis
elegans) 		5 / 9 ARG A  28
GLY A 171
ALA A 196
VAL A 170
ILE A 172
 None
 1.41A 5i3cA-3k6jA:
undetectable		 5i3cA-3k6jA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE
(Caenorhabditis
elegans) 		4 / 8 LEU A 118
VAL A  42
VAL A  39
ILE A 207
 None
 0.75A 5y9mA-3k6jA:
undetectable		 5y9mA-3k6jA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE
(Caenorhabditis
elegans) 		4 / 8 LEU A 118
VAL A  42
VAL A  39
ILE A 207
 None
 0.70A 5y9mX-3k6jA:
undetectable		 5y9mX-3k6jA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE
(Caenorhabditis
elegans) 		5 / 12 LEU A 376
GLY A 379
VAL A 212
ASP A 371
ILE A 375
 None
 0.98A 6emuA-3k6jA:
undetectable		 6emuA-3k6jA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE
(Caenorhabditis
elegans) 		4 / 8 VAL A 263
TYR A   2
ASN A 176
GLU A  86
 None
None
PO4  A 502 (-3.7A)
PO4  A 502 (-3.3A)
 1.33A 6gneB-3k6jA:
2.8		 6gneB-3k6jA:
20.75