SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k6k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		5 / 12 GLY A  88
GLY A  89
GLY A  90
SER A 157
HIS A 281
 None
 0.42A 1dx6A-3k6kA:
16.8		 1dx6A-3k6kA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		5 / 10 GLY A 159
GLN A 284
TYR A  85
THR A 163
GLY A 160
 None
 1.45A 1kvlA-3k6kA:
undetectable		 1kvlA-3k6kA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		5 / 10 GLY A 159
LEU A 102
TYR A  85
THR A 163
GLY A 160
 None
 1.09A 1kvlA-3k6kA:
undetectable		 1kvlA-3k6kA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		5 / 12 GLY A  88
GLY A  89
GLY A  90
SER A 157
HIS A 281
 None
 0.44A 1qtiA-3k6kA:
16.4		 1qtiA-3k6kA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		4 / 5 LEU A 212
ALA A 252
LEU A 192
SER A 193
 None
 1.13A 1tt6B-3k6kA:
undetectable		 1tt6B-3k6kA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		5 / 12 GLY A  88
GLY A  89
GLY A  90
SER A 157
HIS A 281
 None
 0.42A 1w6rA-3k6kA:
5.7		 1w6rA-3k6kA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		5 / 12 GLY A  89
GLY A  90
SER A 157
LEU A 192
HIS A 281
 None
 0.64A 1ya4A-3k6kA:
16.8		 1ya4A-3k6kA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		5 / 12 GLY A  89
GLY A  90
SER A 157
LEU A 192
HIS A 281
 None
 0.69A 1ya4B-3k6kA:
16.6		 1ya4B-3k6kA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		5 / 12 GLY A  89
GLY A  90
SER A 157
LEU A 206
HIS A 281
 None
 0.54A 1ya4B-3k6kA:
16.6		 1ya4B-3k6kA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		5 / 12 GLY A  89
GLY A  90
SER A 157
LEU A 192
HIS A 281
 None
 0.67A 1ya4C-3k6kA:
16.8		 1ya4C-3k6kA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		5 / 12 GLY A  89
GLY A  90
SER A 157
LEU A 206
HIS A 281
 None
 0.62A 1ya4C-3k6kA:
16.8		 1ya4C-3k6kA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		5 / 9 GLY A  88
GLY A  89
SER A 157
ALA A 158
HIS A 281
 None
 0.94A 2aceA-3k6kA:
4.4		 2aceA-3k6kA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		5 / 9 GLY A  89
GLY A  90
SER A 157
ALA A 158
HIS A 281
 None
 0.47A 2aceA-3k6kA:
4.4		 2aceA-3k6kA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		4 / 6 LEU A 106
TYR A  85
ILE A 300
GLY A 159
 None
 0.94A 2du8B-3k6kA:
1.7		 2du8B-3k6kA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		4 / 8 GLY A  89
GLY A  90
ALA A 158
HIS A 281
 None
 0.26A 2ha4A-3k6kA:
3.2		 2ha4A-3k6kA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		4 / 7 GLY A  89
GLY A  90
ALA A 158
HIS A 281
 None
 0.25A 2ha4B-3k6kA:
16.8		 2ha4B-3k6kA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		5 / 12 ALA A 264
ASP A 189
PRO A 186
GLY A 161
LEU A 162
 None
 1.37A 2nv4B-3k6kA:
undetectable		 2nv4B-3k6kA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		4 / 7 ILE A 230
TYR A  91
PHE A 187
ASP A 256
 None
 1.04A 2qebA-3k6kA:
undetectable		 2qebA-3k6kA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		4 / 7 ILE A 230
TYR A  91
PHE A 187
ASP A 256
 None
 1.01A 2qebB-3k6kA:
undetectable		 2qebB-3k6kA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		3 / 3 MET A 285
GLU A 251
ASP A 256
 None
 0.92A 3a25A-3k6kA:
2.1		 3a25A-3k6kA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		3 / 3 PRO A  18
LEU A  22
ARG A 203
 None
 0.88A 3aqiA-3k6kA:
3.6		 3aqiA-3k6kA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		4 / 8 GLY A 161
VAL A 188
LEU A 260
PRO A 186
 None
 0.91A 3bgdB-3k6kA:
2.5		 3bgdB-3k6kA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		4 / 6 THR A 164
ILE A 245
SER A 257
LEU A 260
 None
 0.91A 3deuB-3k6kA:
undetectable		 3deuB-3k6kA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		5 / 12 TYR A  85
PHE A  86
SER A 166
THR A 164
ILE A  83
 None
 1.32A 3lcvB-3k6kA:
2.3		 3lcvB-3k6kA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		4 / 7 GLY A  89
GLY A  90
SER A 157
HIS A 281
 None
 0.41A 3o9mA-3k6kA:
17.0		 3o9mA-3k6kA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		4 / 6 GLY A  89
GLY A  90
SER A 157
HIS A 281
 None
 0.35A 3o9mB-3k6kA:
16.9		 3o9mB-3k6kA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		6 / 12 GLY A  88
GLY A  89
GLY A  90
SER A  93
SER A 157
HIS A 281
 None
 0.39A 4ey6A-3k6kA:
16.9		 4ey6A-3k6kA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		5 / 12 GLY A  88
GLY A  89
GLY A  90
SER A 157
HIS A 281
 None
 0.44A 4ey6B-3k6kA:
16.5		 4ey6B-3k6kA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		5 / 10 GLY A  94
GLY A  88
ILE A  71
GLN A  73
LEU A 100
 None
 1.02A 5l0zB-3k6kA:
2.6		 5l0zB-3k6kA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		5 / 12 MET A 243
ILE A 245
LEU A 240
THR A 164
LEU A 254
 None
 1.20A 6b54A-3k6kA:
undetectable		 6b54A-3k6kA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 3k6k ESTERASE/LIPASE
(uncultured
bacterium) 		4 / 6 LEU A 253
ALA A 207
LEU A 190
SER A 157
 None
 0.88A 6f88B-3k6kA:
undetectable		 6f88B-3k6kA:
13.21