SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k6r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3k6r PUTATIVE TRANSFERASE
PH0793
(Pyrococcus
horikoshii) 		3 / 3 ARG A 118
ASP A 131
ASN A 184
 None
 0.78A 1nbhA-3k6rA:
14.7		 1nbhA-3k6rA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3k6r PUTATIVE TRANSFERASE
PH0793
(Pyrococcus
horikoshii) 		3 / 3 ARG A 118
ASP A 131
ASN A 184
 None
 0.76A 1nbhD-3k6rA:
14.5		 1nbhD-3k6rA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 3k6r PUTATIVE TRANSFERASE
PH0793
(Pyrococcus
horikoshii) 		5 / 12 GLY A 135
GLY A 137
ILE A 154
ALA A 153
PHE A 163
 None
 1.07A 1ri4A-3k6rA:
14.4		 1ri4A-3k6rA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3k6r PUTATIVE TRANSFERASE
PH0793
(Pyrococcus
horikoshii) 		4 / 6 VAL A 130
ILE A 221
ILE A 214
ASP A 194
 None
 0.71A 1uwhA-3k6rA:
undetectable		 1uwhA-3k6rA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3k6r PUTATIVE TRANSFERASE
PH0793
(Pyrococcus
horikoshii) 		4 / 6 VAL A 130
ILE A 221
ILE A 214
ASP A 194
 None
 0.72A 1uwhB-3k6rA:
undetectable		 1uwhB-3k6rA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)		 3k6r PUTATIVE TRANSFERASE
PH0793
(Pyrococcus
horikoshii) 		4 / 8 ALA A 153
VAL A 165
PHE A 161
THR A 160
 None
 1.10A 2kotB-3k6rA:
undetectable		 2kotB-3k6rA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3k6r PUTATIVE TRANSFERASE
PH0793
(Pyrococcus
horikoshii) 		5 / 12 ARG A 116
PHE A 133
GLY A 135
ASP A 183
PHE A 207
 None
 0.76A 2zznA-3k6rA:
26.7		 2zznA-3k6rA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3k6r PUTATIVE TRANSFERASE
PH0793
(Pyrococcus
horikoshii) 		6 / 12 PHE A 108
ARG A 116
PHE A 133
GLY A 135
ASP A 183
PHE A 207
 None
 0.79A 2zznB-3k6rA:
26.1		 2zznB-3k6rA:
29.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 3k6r PUTATIVE TRANSFERASE
PH0793
(Pyrococcus
horikoshii) 		12 / 12 SER A 109
ASN A 112
ARG A 116
PHE A 133
GLY A 135
HIS A 138
ILE A 154
LYS A 156
ASP A 157
THR A 160
ASN A 184
PHE A 207
 None
 0.48A 3a25A-3k6rA:
38.4		 3a25A-3k6rA:
92.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A27_A_SAMA250_0
(UNCHARACTERIZED
PROTEIN MJ1557)		 3k6r PUTATIVE TRANSFERASE
PH0793
(Pyrococcus
horikoshii) 		6 / 12 ARG A 116
PHE A 133
GLY A 135
ARG A 185
TYR A 200
PHE A 207
 None
 0.76A 3a27A-3k6rA:
30.1		 3a27A-3k6rA:
40.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A27_A_SAMA250_0
(UNCHARACTERIZED
PROTEIN MJ1557)		 3k6r PUTATIVE TRANSFERASE
PH0793
(Pyrococcus
horikoshii) 		7 / 12 SER A 109
ARG A 116
PHE A 133
GLY A 135
ASP A 183
TYR A 200
PHE A 207
 None
 0.55A 3a27A-3k6rA:
30.1		 3a27A-3k6rA:
40.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 3k6r PUTATIVE TRANSFERASE
PH0793
(Pyrococcus
horikoshii) 		5 / 12 GLY A 135
GLU A 155
LYS A 156
ASP A 157
ASP A 183
 None
 0.72A 3fuuA-3k6rA:
13.0		 3fuuA-3k6rA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 3k6r PUTATIVE TRANSFERASE
PH0793
(Pyrococcus
horikoshii) 		5 / 12 LEU A 271
PHE A 237
VAL A 251
MET A 132
ALA A 211
 None
 1.36A 3nuvA-3k6rA:
undetectable		 3nuvA-3k6rA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)		 3k6r PUTATIVE TRANSFERASE
PH0793
(Pyrococcus
horikoshii) 		6 / 12 LEU A 197
ASP A 131
ALA A 153
ILE A 168
ILE A 136
PRO A 142
 None
 1.49A 3tkwB-3k6rA:
undetectable		 3tkwB-3k6rA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 3k6r PUTATIVE TRANSFERASE
PH0793
(Pyrococcus
horikoshii) 		5 / 9 ASP A 131
ALA A 153
ILE A 168
ILE A 136
PRO A 142
 None
 1.23A 3u7sB-3k6rA:
undetectable		 3u7sB-3k6rA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 3k6r PUTATIVE TRANSFERASE
PH0793
(Pyrococcus
horikoshii) 		6 / 9 LEU A 197
ASP A 131
ALA A 153
ILE A 168
ILE A 136
PRO A 142
 None
 1.29A 3u7sA-3k6rA:
undetectable		 3u7sA-3k6rA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3k6r PUTATIVE TRANSFERASE
PH0793
(Pyrococcus
horikoshii) 		3 / 3 GLU A 155
ASP A 157
ASP A 183
 None
 0.34A 4gc9A-3k6rA:
10.6		 4gc9A-3k6rA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3k6r PUTATIVE TRANSFERASE
PH0793
(Pyrococcus
horikoshii) 		3 / 3 LEU A  39
PRO A  40
ARG A  11
 None
 0.73A 4klrB-3k6rA:
2.2		 4klrB-3k6rA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_1
(PROTEASE)		 3k6r PUTATIVE TRANSFERASE
PH0793
(Pyrococcus
horikoshii) 		6 / 11 LEU A 197
ASP A 131
ALA A 153
ILE A 168
ILE A 136
PRO A 142
 None
 1.41A 4njtA-3k6rA:
undetectable		 4njtA-3k6rA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_1
(PROTEASE)		 3k6r PUTATIVE TRANSFERASE
PH0793
(Pyrococcus
horikoshii) 		6 / 11 LEU A 197
ASP A 131
ALA A 153
ILE A 168
ILE A 136
PRO A 142
 None
 1.42A 4njtC-3k6rA:
undetectable		 4njtC-3k6rA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3k6r PUTATIVE TRANSFERASE
PH0793
(Pyrococcus
horikoshii) 		5 / 12 LEU A 128
ILE A 192
ILE A 214
ALA A 153
ILE A 143
 None
 1.05A 4nkxA-3k6rA:
undetectable		 4nkxA-3k6rA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 3k6r PUTATIVE TRANSFERASE
PH0793
(Pyrococcus
horikoshii) 		3 / 3 ASP A  87
VAL A 103
LEU A  66
 None
 0.68A 5e5jB-3k6rA:
undetectable		 5e5jB-3k6rA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3k6r PUTATIVE TRANSFERASE
PH0793
(Pyrococcus
horikoshii) 		4 / 7 VAL A 113
HIS A  92
PRO A 110
ILE A  33
 None
 1.20A 5vkqA-3k6rA:
undetectable
5vkqB-3k6rA:
undetectable		 5vkqA-3k6rA:
11.43
5vkqB-3k6rA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3k6r PUTATIVE TRANSFERASE
PH0793
(Pyrococcus
horikoshii) 		4 / 7 VAL A 113
HIS A  92
PRO A 110
ILE A  33
 None
 1.18A 5vkqC-3k6rA:
undetectable
5vkqD-3k6rA:
undetectable		 5vkqC-3k6rA:
11.43
5vkqD-3k6rA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 3k6r PUTATIVE TRANSFERASE
PH0793
(Pyrococcus
horikoshii) 		4 / 5 GLU A 127
VAL A 129
LEU A 197
HIS A 224
 None
 1.50A 6dyoA-3k6rA:
undetectable		 6dyoA-3k6rA:
16.40