SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k6x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 3k6x SOLUTE-BINDING
PROTEIN MA_0280
(Methanosarcina
acetivorans) 		4 / 7 GLY A 164
PRO A 162
SER A 156
ALA A  48
 None
MOO  A 500 (-3.3A)
None
MOO  A 500 (-3.2A)
 0.97A 1gxsA-3k6xA:
undetectable
1gxsB-3k6xA:
undetectable		 1gxsA-3k6xA:
22.07
1gxsB-3k6xA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3k6x SOLUTE-BINDING
PROTEIN MA_0280
(Methanosarcina
acetivorans) 		4 / 8 LEU A  58
PHE A 311
LEU A 315
PHE A 118
 None
 0.91A 1v54C-3k6xA:
undetectable
1v54J-3k6xA:
undetectable		 1v54C-3k6xA:
20.87
1v54J-3k6xA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 3k6x SOLUTE-BINDING
PROTEIN MA_0280
(Methanosarcina
acetivorans) 		4 / 7 ALA A 119
ARG A 120
TYR A 100
TYR A 115
 None
SO4  A 501 (-3.1A)
None
None
 1.12A 2ajvH-3k6xA:
undetectable
2ajvL-3k6xA:
undetectable		 2ajvH-3k6xA:
21.05
2ajvL-3k6xA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3k6x SOLUTE-BINDING
PROTEIN MA_0280
(Methanosarcina
acetivorans) 		4 / 7 LEU A  58
PHE A 311
LEU A 315
PHE A 118
 None
 0.95A 2eikC-3k6xA:
undetectable
2eikJ-3k6xA:
undetectable		 2eikC-3k6xA:
20.87
2eikJ-3k6xA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3k6x SOLUTE-BINDING
PROTEIN MA_0280
(Methanosarcina
acetivorans) 		4 / 8 LEU A  58
PHE A 311
LEU A 315
PHE A 118
 None
 0.91A 2eilC-3k6xA:
undetectable
2eilJ-3k6xA:
undetectable		 2eilC-3k6xA:
20.87
2eilJ-3k6xA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3k6x SOLUTE-BINDING
PROTEIN MA_0280
(Methanosarcina
acetivorans) 		4 / 7 LEU A  58
PHE A 311
LEU A 315
PHE A 118
 None
 0.93A 2eimP-3k6xA:
undetectable
2eimW-3k6xA:
undetectable		 2eimP-3k6xA:
20.87
2eimW-3k6xA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 3k6x SOLUTE-BINDING
PROTEIN MA_0280
(Methanosarcina
acetivorans) 		3 / 3 ARG A 148
ASP A 186
ASP A 181
 None
 0.81A 2ejtA-3k6xA:
undetectable		 2ejtA-3k6xA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3k6x SOLUTE-BINDING
PROTEIN MA_0280
(Methanosarcina
acetivorans) 		5 / 12 GLY A 284
HIS A 207
VAL A 277
ASN A 159
GLY A 164
 None
 1.13A 2vmyB-3k6xA:
undetectable		 2vmyB-3k6xA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3k6x SOLUTE-BINDING
PROTEIN MA_0280
(Methanosarcina
acetivorans) 		4 / 6 LEU A  58
PHE A 311
LEU A 315
PHE A 118
 None
 1.01A 3abkP-3k6xA:
undetectable
3abkW-3k6xA:
undetectable		 3abkP-3k6xA:
20.87
3abkW-3k6xA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3k6x SOLUTE-BINDING
PROTEIN MA_0280
(Methanosarcina
acetivorans) 		4 / 8 LEU A  58
PHE A 311
LEU A 315
PHE A 118
 None
 0.91A 3ag4C-3k6xA:
undetectable
3ag4J-3k6xA:
undetectable		 3ag4C-3k6xA:
20.87
3ag4J-3k6xA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3k6x SOLUTE-BINDING
PROTEIN MA_0280
(Methanosarcina
acetivorans) 		4 / 7 LEU A  58
PHE A 311
LEU A 315
PHE A 118
 None
 0.90A 3ag4P-3k6xA:
undetectable
3ag4W-3k6xA:
undetectable		 3ag4P-3k6xA:
20.87
3ag4W-3k6xA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3k6x SOLUTE-BINDING
PROTEIN MA_0280
(Methanosarcina
acetivorans) 		4 / 7 LEU A  58
PHE A 311
LEU A 315
PHE A 118
 None
 0.92A 3asnC-3k6xA:
undetectable
3asnJ-3k6xA:
undetectable		 3asnC-3k6xA:
20.87
3asnJ-3k6xA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3k6x SOLUTE-BINDING
PROTEIN MA_0280
(Methanosarcina
acetivorans) 		4 / 7 LEU A  58
PHE A 311
LEU A 315
PHE A 118
 None
 0.97A 3asnP-3k6xA:
undetectable
3asnW-3k6xA:
undetectable		 3asnP-3k6xA:
20.87
3asnW-3k6xA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3k6x SOLUTE-BINDING
PROTEIN MA_0280
(Methanosarcina
acetivorans) 		4 / 7 LEU A  58
PHE A 311
LEU A 315
PHE A 118
 None
 0.99A 3asoP-3k6xA:
undetectable
3asoW-3k6xA:
undetectable		 3asoP-3k6xA:
20.87
3asoW-3k6xA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 3k6x SOLUTE-BINDING
PROTEIN MA_0280
(Methanosarcina
acetivorans) 		5 / 12 GLY A  77
ASP A 161
PRO A 162
ALA A 163
ALA A  75
 MOO  A 500 (-3.7A)
MOO  A 500 (-2.7A)
MOO  A 500 (-3.3A)
MOO  A 500 (-3.3A)
SO4  A 504 (-3.5A)
 0.86A 3jb1A-3k6xA:
undetectable		 3jb1A-3k6xA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 3k6x SOLUTE-BINDING
PROTEIN MA_0280
(Methanosarcina
acetivorans) 		5 / 12 LEU A 259
LEU A 125
ILE A 137
SER A 131
ALA A 174
 None
 1.23A 3lbdA-3k6xA:
undetectable		 3lbdA-3k6xA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 3k6x SOLUTE-BINDING
PROTEIN MA_0280
(Methanosarcina
acetivorans) 		4 / 7 ILE A 239
LEU A 230
SER A 167
VAL A 208
 None
 1.00A 3r9vA-3k6xA:
undetectable
3r9vB-3k6xA:
undetectable		 3r9vA-3k6xA:
22.03
3r9vB-3k6xA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3k6x SOLUTE-BINDING
PROTEIN MA_0280
(Methanosarcina
acetivorans) 		5 / 12 GLY A  49
ASP A 161
SER A  81
ALA A  79
SER A 105
 MOO  A 500 (-3.5A)
MOO  A 500 (-2.7A)
None
None
None
 1.21A 3sueD-3k6xA:
undetectable		 3sueD-3k6xA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3k6x SOLUTE-BINDING
PROTEIN MA_0280
(Methanosarcina
acetivorans) 		4 / 7 LEU A  58
PHE A 311
LEU A 315
PHE A 118
 None
 0.96A 3x2qC-3k6xA:
undetectable
3x2qJ-3k6xA:
undetectable		 3x2qC-3k6xA:
20.87
3x2qJ-3k6xA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 3k6x SOLUTE-BINDING
PROTEIN MA_0280
(Methanosarcina
acetivorans) 		5 / 12 LEU A  95
LEU A  58
SER A  81
PHE A 118
GLY A 320
 None
 0.84A 4dm8B-3k6xA:
undetectable		 4dm8B-3k6xA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 3k6x SOLUTE-BINDING
PROTEIN MA_0280
(Methanosarcina
acetivorans) 		5 / 12 GLY A 134
PHE A 254
ASN A 138
VAL A 257
LEU A 125
 None
 1.04A 4fr0A-3k6xA:
undetectable		 4fr0A-3k6xA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 3k6x SOLUTE-BINDING
PROTEIN MA_0280
(Methanosarcina
acetivorans) 		5 / 10 TYR A 165
LEU A 102
LEU A  51
ALA A  48
GLY A 295
 None
None
None
MOO  A 500 (-3.2A)
None
 1.25A 4rn6A-3k6xA:
undetectable		 4rn6A-3k6xA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 3k6x SOLUTE-BINDING
PROTEIN MA_0280
(Methanosarcina
acetivorans) 		5 / 12 LEU A 173
ALA A 174
TYR A 143
ALA A 163
TYR A 245
 None
None
None
MOO  A 500 (-3.3A)
MOO  A 500 (-4.7A)
 1.08A 5n5dB-3k6xA:
undetectable		 5n5dB-3k6xA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3k6x SOLUTE-BINDING
PROTEIN MA_0280
(Methanosarcina
acetivorans) 		4 / 5 LEU A  58
PHE A 311
LEU A 315
PHE A 118
 None
 0.87A 5x19C-3k6xA:
undetectable
5x19J-3k6xA:
undetectable		 5x19C-3k6xA:
20.87
5x19J-3k6xA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3k6x SOLUTE-BINDING
PROTEIN MA_0280
(Methanosarcina
acetivorans) 		4 / 7 LEU A  58
PHE A 311
LEU A 315
PHE A 118
 None
 0.87A 5x1fP-3k6xA:
undetectable
5x1fW-3k6xA:
undetectable		 5x1fP-3k6xA:
20.87
5x1fW-3k6xA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXJ_A_SAMA505_0
(SMYD3)		 3k6x SOLUTE-BINDING
PROTEIN MA_0280
(Methanosarcina
acetivorans) 		5 / 12 GLY A 237
GLU A 130
ASN A 129
HIS A 252
PHE A 254
 None
 1.48A 5xxjA-3k6xA:
undetectable		 5xxjA-3k6xA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3k6x SOLUTE-BINDING
PROTEIN MA_0280
(Methanosarcina
acetivorans) 		3 / 3 LYS A 276
ASN A 273
SER A 176
 None
 1.02A 5yw0A-3k6xA:
undetectable		 5yw0A-3k6xA:
22.37