SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k70'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		3 / 3 THR D 239
PRO D 204
THR D 205
 None
 0.84A 1a7yB-3k70D:
undetectable		 1a7yB-3k70D:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		3 / 3 THR D 239
PRO D 204
THR D 205
 None
 0.91A 1dscC-3k70D:
undetectable		 1dscC-3k70D:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		3 / 3 THR D 205
THR D 239
PRO D 204
 None
 0.79A 1dscC-3k70D:
undetectable		 1dscC-3k70D:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		3 / 3 ASP B 388
ASP B 426
ASP B 414
 None
 0.78A 1eizA-3k70B:
2.8		 1eizA-3k70B:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		4 / 8 ALA B 163
LEU B 159
LEU B 158
LEU B 201
 None
 0.93A 1ereE-3k70B:
undetectable		 1ereE-3k70B:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		4 / 8 ALA B 163
LEU B 159
LEU B 158
LEU B 201
 None
 0.94A 1ereF-3k70B:
undetectable		 1ereF-3k70B:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		4 / 5 LEU D  53
GLU D  62
ALA D  38
LEU D  42
 None
 1.02A 1eta1-3k70D:
undetectable		 1eta1-3k70D:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		4 / 5 LEU D  53
GLU D  62
ALA D  38
LEU D  42
 None
 1.01A 1eta2-3k70D:
undetectable		 1eta2-3k70D:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		4 / 6 LEU D  53
GLU D  62
ALA D  38
LEU D  42
 None
 1.03A 1etb1-3k70D:
undetectable		 1etb1-3k70D:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		4 / 4 THR B  55
LEU B  59
VAL B 380
LEU B 410
 None
 1.08A 1fbmB-3k70B:
undetectable		 1fbmB-3k70B:
3.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		3 / 3 THR D 205
THR D 239
PRO D 204
 None
 0.80A 1fjaC-3k70D:
undetectable		 1fjaC-3k70D:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		3 / 3 THR D 205
THR D 239
PRO D 204
 None
 0.80A 1fjaD-3k70D:
undetectable		 1fjaD-3k70D:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		3 / 3 THR D 205
THR D 239
PRO D 204
 None
 0.84A 1i3wG-3k70D:
undetectable		 1i3wG-3k70D:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		3 / 3 THR D 205
THR D 239
PRO D 204
 None
 0.87A 1i3wH-3k70D:
undetectable		 1i3wH-3k70D:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		4 / 7 VAL D 160
LEU D 329
THR D 333
LEU D 141
 None
 0.76A 1jgsA-3k70D:
0.0		 1jgsA-3k70D:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		5 / 11 ALA D 373
VAL D 566
ALA D 589
ALA D 588
THR D 384
 None
 1.02A 1jinA-3k70D:
undetectable		 1jinA-3k70D:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		4 / 7 ILE D 552
LEU D 565
LEU D 444
GLY D 450
 None
 0.89A 1mt1H-3k70D:
undetectable
1mt1K-3k70D:
undetectable		 1mt1H-3k70D:
10.89
1mt1K-3k70D:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		3 / 3 THR D 239
PRO D 204
THR D 205
 None
 0.88A 1ovfB-3k70D:
undetectable		 1ovfB-3k70D:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		5 / 12 ALA D 452
LEU D 579
GLY D 447
LEU D 553
GLN D 399
 None
 1.25A 1qabF-3k70D:
undetectable		 1qabF-3k70D:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		5 / 12 LEU D 441
LEU D 553
ALA D 588
ALA D 591
ALA D 589
 None
 1.37A 1rbpA-3k70D:
undetectable		 1rbpA-3k70D:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		4 / 8 LEU D  53
GLU D  62
ALA D  38
LEU D  42
 None
 0.88A 1sn5C-3k70D:
undetectable		 1sn5C-3k70D:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		3 / 3 THR D 205
THR D 239
PRO D 204
 None
 0.85A 1unmE-3k70D:
undetectable		 1unmE-3k70D:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		3 / 3 THR D 239
PRO D 204
THR D 205
 None
 0.80A 1unmF-3k70D:
undetectable		 1unmF-3k70D:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		3 / 3 THR D 205
THR D 239
PRO D 204
 None
 0.78A 1unmF-3k70D:
undetectable		 1unmF-3k70D:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		4 / 8 SER B1083
LEU B1086
LEU B 977
SER B 950
 None
 1.01A 1wrlC-3k70B:
undetectable
1wrlD-3k70B:
undetectable		 1wrlC-3k70B:
6.47
1wrlD-3k70B:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		5 / 12 ASP B 798
LEU B 799
THR B 807
MET B 499
SER B 456
 None
 1.35A 1xoqA-3k70B:
undetectable		 1xoqA-3k70B:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		5 / 12 ASP B 798
LEU B 799
THR B 807
MET B 499
SER B 456
 None
 1.33A 1xoqB-3k70B:
undetectable		 1xoqB-3k70B:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		4 / 4 LEU B 754
SER B 744
LEU B 802
LEU B 806
 None
 1.14A 1yajA-3k70B:
1.0		 1yajA-3k70B:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_B_NCAB508_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		4 / 5 GLN B1103
LEU B1046
TYR B1156
GLN B1095
 None
 1.34A 1yc2B-3k70B:
1.9
1yc2C-3k70B:
undetectable		 1yc2B-3k70B:
12.18
1yc2C-3k70B:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		3 / 3 THR D 205
THR D 239
PRO D 204
 None
 0.77A 209dC-3k70D:
undetectable		 209dC-3k70D:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		4 / 7 ARG B 341
ARG B 170
GLN B 162
GLU B 342
 None
 1.16A 2c8aA-3k70B:
undetectable		 2c8aA-3k70B:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		5 / 11 ALA D 271
ILE D 274
VAL D 168
LEU D 348
ILE D 166
 None
 1.14A 2h42A-3k70D:
undetectable		 2h42A-3k70D:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		4 / 7 GLU B 681
MET B 620
ARG B 682
GLY B 680
 None
 1.27A 2hs1B-3k70B:
undetectable		 2hs1B-3k70B:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		4 / 6 LEU B1079
VAL B 989
VAL B1146
ILE B 994
 None
 0.99A 2hyyA-3k70B:
undetectable		 2hyyA-3k70B:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		4 / 4 ASP B1089
LEU B1086
GLY B1087
ARG B 947
 None
 1.48A 2j2pD-3k70B:
undetectable
2j2pE-3k70B:
undetectable		 2j2pD-3k70B:
10.34
2j2pE-3k70B:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		5 / 11 GLY D 320
ALA D 159
VAL D 337
PRO D 338
ILE D 151
 None
 0.94A 2nnhA-3k70D:
undetectable		 2nnhA-3k70D:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		4 / 5 LEU B 571
ARG B 568
ALA B 570
ILE B 738
 None
 0.85A 2qhfA-3k70B:
undetectable		 2qhfA-3k70B:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		3 / 3 ARG B 655
GLN B 695
PRO B 659
 None
 0.72A 2qhfA-3k70B:
undetectable		 2qhfA-3k70B:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		4 / 7 ILE D 552
LEU D 565
LEU D 444
GLY D 450
 None
 0.85A 2qqcD-3k70D:
undetectable
2qqcE-3k70D:
undetectable		 2qqcD-3k70D:
10.89
2qqcE-3k70D:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		4 / 8 ILE D 552
LEU D 565
LEU D 444
GLY D 450
 None
 0.87A 2qqcH-3k70D:
undetectable
2qqcK-3k70D:
undetectable		 2qqcH-3k70D:
10.89
2qqcK-3k70D:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		4 / 6 LEU D  53
GLU D  62
ALA D  38
LEU D  42
 None
 1.01A 2roxB-3k70D:
undetectable		 2roxB-3k70D:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		4 / 7 LEU D 454
ASN D 455
MET D 407
TYR D 415
 None
 1.25A 2w8yA-3k70D:
undetectable		 2w8yA-3k70D:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		4 / 6 HIS B 914
ALA B 929
ALA B 949
THR B 953
 None
 0.74A 2xfhA-3k70B:
undetectable		 2xfhA-3k70B:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		3 / 3 MET B 921
GLU B1020
ASP B 961
 None
 0.88A 3a25A-3k70B:
undetectable		 3a25A-3k70B:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		4 / 7 VAL D 268
ILE D 199
ARG D 232
LEU D 225
 None
 0.85A 3bjwH-3k70D:
undetectable		 3bjwH-3k70D:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		5 / 12 GLY B 839
ILE B 865
LEU B 860
LEU B 806
LEU B 815
 None
 0.95A 3cs8A-3k70B:
undetectable		 3cs8A-3k70B:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		5 / 12 THR D 175
VAL D 156
ALA D 158
THR D 335
THR D 333
 None
 1.22A 3dl9B-3k70D:
undetectable		 3dl9B-3k70D:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		3 / 3 ASP B 388
ASP B 426
ASP B 414
 None
 0.68A 3douA-3k70B:
2.5		 3douA-3k70B:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2U_A_ELVA397_1
(INTEGRASE)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		4 / 5 ASP B 359
TYR B 394
PRO B 391
GLU B 204
 None
 1.35A 3l2uA-3k70B:
0.7		 3l2uA-3k70B:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		5 / 9 VAL B 558
PHE B 756
ILE B 738
ALA B 570
THR B 572
 None
 1.06A 3me6D-3k70B:
undetectable		 3me6D-3k70B:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		5 / 8 PHE B 475
PHE B 461
PHE B 468
ALA B  25
THR B  27
 None
 1.45A 3t3sD-3k70B:
undetectable		 3t3sD-3k70B:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		4 / 6 ARG D 557
PHE D 449
PRO D 448
LEU D 444
 None
 0.98A 3tgvB-3k70D:
undetectable		 3tgvB-3k70D:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_C_BEZC1_0
(HEME-BINDING PROTEIN
HUTZ)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		4 / 5 ARG D 557
PHE D 449
PRO D 448
LEU D 444
 None
 0.85A 3tgvC-3k70D:
undetectable		 3tgvC-3k70D:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		4 / 6 ARG D 557
PHE D 449
PRO D 448
LEU D 444
 None
 0.97A 3tgvD-3k70D:
undetectable		 3tgvD-3k70D:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		5 / 12 GLY D  47
ARG D  17
HIS D  50
ARG D 111
SER D  43
 None
 1.38A 3tkaA-3k70D:
undetectable		 3tkaA-3k70D:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_A_CLMA221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		5 / 9 SER D 303
SER D 170
LEU D 352
PHE D 123
VAL D 168
 None
 1.16A 3u9fA-3k70D:
0.0		 3u9fA-3k70D:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		5 / 12 SER D 303
SER D 170
LEU D 352
PHE D 123
VAL D 168
 None
 1.15A 3u9fB-3k70D:
undetectable
3u9fC-3k70D:
undetectable		 3u9fB-3k70D:
16.14
3u9fC-3k70D:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		5 / 10 SER D 303
SER D 170
LEU D 352
PHE D 123
VAL D 168
 None
 1.12A 3u9fK-3k70D:
undetectable		 3u9fK-3k70D:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		5 / 10 SER D 303
SER D 170
LEU D 352
PHE D 123
VAL D 168
 None
 1.18A 3u9fR-3k70D:
undetectable		 3u9fR-3k70D:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		5 / 11 MET D 407
GLY D 401
PRO D 448
PHE D 449
GLY D 453
 None
 1.26A 3v3nA-3k70D:
undetectable		 3v3nA-3k70D:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		5 / 11 PHE B 954
GLY B 980
PRO B 946
PHE B 945
GLY B 948
 None
 1.46A 3v3nA-3k70B:
undetectable		 3v3nA-3k70B:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		3 / 3 ARG B 398
LYS B 432
ARG B 395
 None
 1.28A 3w1wA-3k70B:
2.9
3w1wB-3k70B:
3.5		 3w1wA-3k70B:
15.37
3w1wB-3k70B:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		3 / 3 ARG B 395
ARG B 398
LYS B 432
 None
 1.34A 3w1wA-3k70B:
2.9
3w1wB-3k70B:
3.5		 3w1wA-3k70B:
15.37
3w1wB-3k70B:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		5 / 12 LEU B 557
LEU B 754
LEU B 815
MET B 453
VAL B 457
 None
 1.35A 3zqtA-3k70B:
undetectable		 3zqtA-3k70B:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		3 / 3 LEU B 370
GLU B 368
SER B 366
 None
 0.76A 4ccqA-3k70B:
undetectable		 4ccqA-3k70B:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		4 / 8 SER D 587
ASP D 378
VAL D 385
THR D 384
 None
 1.11A 4lnwA-3k70D:
undetectable		 4lnwA-3k70D:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		5 / 12 GLU B1020
ASP B1067
LEU B 924
GLY B 952
HIS B 956
 None
CA  B4000 (-3.1A)
None
None
CA  B4000 (-4.0A)
 1.47A 4pfjB-3k70B:
undetectable		 4pfjB-3k70B:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		5 / 12 PHE B 461
ILE B 857
LEU B 806
LEU B 802
LEU B 838
 None
 1.13A 4xumA-3k70B:
undetectable		 4xumA-3k70B:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		3 / 3 LEU D 244
ARG D 242
ARG D 200
 None
 0.96A 4yiaB-3k70D:
undetectable		 4yiaB-3k70D:
4.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		4 / 7 THR D 163
LEU D 162
LEU D 137
THR D 333
 None
 0.65A 4z90A-3k70D:
undetectable
4z90B-3k70D:
undetectable
4z90C-3k70D:
undetectable
4z90D-3k70D:
undetectable
4z90E-3k70D:
undetectable		 4z90A-3k70D:
19.66
4z90B-3k70D:
19.66
4z90C-3k70D:
19.66
4z90D-3k70D:
19.66
4z90E-3k70D:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		4 / 8 LEU D 137
THR D 333
THR D 163
LEU D 162
 None
 0.73A 4z90F-3k70D:
undetectable
4z90G-3k70D:
undetectable
4z90H-3k70D:
undetectable
4z90I-3k70D:
undetectable
4z90J-3k70D:
undetectable		 4z90F-3k70D:
19.66
4z90G-3k70D:
19.66
4z90H-3k70D:
19.66
4z90I-3k70D:
19.66
4z90J-3k70D:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		4 / 8 THR D 333
THR D 163
LEU D 162
LEU D 137
 None
 0.67A 4z90F-3k70D:
undetectable
4z90G-3k70D:
undetectable
4z90H-3k70D:
undetectable
4z90I-3k70D:
undetectable
4z90J-3k70D:
undetectable		 4z90F-3k70D:
19.66
4z90G-3k70D:
19.66
4z90H-3k70D:
19.66
4z90I-3k70D:
19.66
4z90J-3k70D:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		5 / 11 ALA B 850
GLY B 506
VAL B 833
LEU B 838
LEU B 842
 None
 1.15A 4zmeA-3k70B:
undetectable		 4zmeA-3k70B:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		4 / 6 ARG D 121
ASP D 284
ARG D 281
ILE D 283
 None
 1.12A 5a06A-3k70D:
undetectable		 5a06A-3k70D:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		4 / 5 GLU D  74
ALA D  69
GLU D  62
ASN D  60
 None
 1.28A 5dwkC-3k70D:
undetectable		 5dwkC-3k70D:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		5 / 12 GLY B 424
ALA B 433
THR B 389
ASP B 388
LEU B  20
 None
 1.03A 5e72A-3k70B:
2.7		 5e72A-3k70B:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		3 / 3 MET D 462
GLN D 463
ARG D 466
 None
 0.75A 5ewzB-3k70D:
undetectable		 5ewzB-3k70D:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		4 / 6 PHE B 475
PRO B 474
THR B 442
ILE B 476
 None
 1.44A 5ih0A-3k70B:
undetectable		 5ih0A-3k70B:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		4 / 6 VAL D 292
SER D 167
ILE D 313
PHE D 123
 None
 1.07A 5jw1B-3k70D:
undetectable		 5jw1B-3k70D:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJD_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		5 / 9 LEU B 860
ILE B 757
ILE B 857
LEU B 806
MET B 499
 None
 1.32A 5ljdA-3k70B:
undetectable		 5ljdA-3k70B:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		4 / 5 VAL B 327
THR B 186
ASP B 196
LEU B 193
 None
 1.14A 5m0iB-3k70B:
undetectable		 5m0iB-3k70B:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		3 / 3 MET D 462
GLN D 463
ARG D 466
 None
 0.75A 5m35B-3k70D:
undetectable		 5m35B-3k70D:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		3 / 3 MET B1102
GLN B1103
ARG B1106
 None
 1.13A 5m35B-3k70B:
3.0		 5m35B-3k70B:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		3 / 3 MET D 462
GLN D 463
ARG D 466
 None
 0.79A 5m36A-3k70D:
undetectable		 5m36A-3k70D:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_1
(MINERALOCORTICOID
RECEPTOR)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		4 / 6 GLN D 328
PHE D 321
THR D 180
PHE D 145
 None
 1.38A 5mwyA-3k70D:
undetectable		 5mwyA-3k70D:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		5 / 12 GLU B 696
SER B 723
PHE B 588
ARG B 709
LEU B 694
 None
 1.19A 5nd4B-3k70B:
undetectable		 5nd4B-3k70B:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		5 / 12 LEU B 694
VAL B 708
LEU B 711
MET B 660
LEU B 661
 None
 0.99A 5og9B-3k70B:
undetectable		 5og9B-3k70B:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		4 / 5 GLY B 510
ARG B 822
ASP B 513
GLN B 520
 None
 1.30A 5ubbA-3k70B:
3.7		 5ubbA-3k70B:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		5 / 12 LEU B 675
LEU B 674
GLY B 680
GLY B 679
LEU B 688
 None
 0.98A 5uc1A-3k70B:
undetectable		 5uc1A-3k70B:
5.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		5 / 12 LEU B 675
LEU B 674
GLY B 680
GLY B 679
LEU B 688
 None
 0.98A 5uc1B-3k70B:
undetectable		 5uc1B-3k70B:
5.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		5 / 10 TYR B1077
ILE B1165
LEU B1164
ILE B1139
ASN B1003
 None
 1.32A 5vkqA-3k70B:
3.2
5vkqD-3k70B:
3.2		 5vkqA-3k70B:
22.07
5vkqD-3k70B:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		5 / 10 ILE B1139
ASN B1003
TYR B1077
ILE B1165
LEU B1164
 None
 1.35A 5vkqC-3k70B:
3.2
5vkqD-3k70B:
3.2		 5vkqC-3k70B:
22.07
5vkqD-3k70B:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		3 / 3 TYR B1129
ASP B1128
ASP B1130
 None
 0.83A 5x6yA-3k70B:
2.8		 5x6yA-3k70B:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		4 / 5 LEU B  59
PHE B 378
LEU B  54
PHE B  50
 None
 1.26A 5xdxC-3k70B:
undetectable
5xdxJ-3k70B:
undetectable		 5xdxC-3k70B:
12.40
5xdxJ-3k70B:
4.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		4 / 5 LEU B  59
PHE B 378
LEU B  54
PHE B  50
 None
 1.29A 5xdxP-3k70B:
undetectable
5xdxW-3k70B:
undetectable		 5xdxP-3k70B:
12.40
5xdxW-3k70B:
4.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		4 / 6 PRO B 451
GLY B 452
ASN B 455
LYS B 459
 None
 0.74A 5xxiA-3k70B:
undetectable		 5xxiA-3k70B:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		3 / 3 VAL D 570
TYR D 567
GLU D 394
 None
 0.92A 5zmqD-3k70D:
undetectable
5zmqE-3k70D:
undetectable		 5zmqD-3k70D:
14.97
5zmqE-3k70D:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		5 / 12 GLU B1020
ASP B1067
LEU B 924
GLY B 952
HIS B 956
 None
CA  B4000 (-3.1A)
None
None
CA  B4000 (-4.0A)
 1.49A 6aphA-3k70B:
undetectable		 6aphA-3k70B:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		5 / 12 ALA B 124
LEU B  60
HIS B 130
THR B  69
LEU B  72
 None
 1.12A 6djzC-3k70B:
undetectable		 6djzC-3k70B:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		3 / 3 MET D 462
GLN D 463
ARG D 466
 None
 0.78A 6fn9A-3k70D:
undetectable		 6fn9A-3k70D:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		3 / 3 MET D 462
GLN D 463
ARG D 466
 None
 0.78A 6fnaB-3k70D:
undetectable		 6fnaB-3k70D:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		3 / 3 MET B1102
GLN B1103
ARG B1106
 None
 1.15A 6fnaB-3k70B:
2.7		 6fnaB-3k70B:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN
(Escherichia
coli) 		3 / 3 MET D 462
GLN D 463
ARG D 466
 None
 0.78A 6fnbA-3k70D:
undetectable		 6fnbA-3k70D:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN
(Escherichia
coli) 		5 / 7 GLY B1154
TYR B1093
HIS B1105
ASN B1084
GLY B1087
 None
 1.04A 6n7fA-3k70B:
undetectable		 6n7fA-3k70B:
4.90