SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k77'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1V_A_H4BA700_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.45A 1d1vA-3k77A:
undetectable
1d1vB-3k77A:
undetectable		 1d1vA-3k77A:
15.32
1d1vB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1V_B_H4BB701_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.49A 1d1vA-3k77A:
undetectable
1d1vB-3k77A:
undetectable		 1d1vA-3k77A:
15.32
1d1vB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1W_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.48A 1d1wA-3k77A:
undetectable
1d1wB-3k77A:
undetectable		 1d1wA-3k77A:
15.32
1d1wB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1X_A_H4BA600_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME DOMAIN)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.47A 1d1xA-3k77A:
0.0
1d1xB-3k77A:
0.0		 1d1xA-3k77A:
15.32
1d1xB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DM8_A_H4BA1600_1
(NITRIC OXIDE
SYNTHASE)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.47A 1dm8A-3k77A:
undetectable
1dm8B-3k77A:
undetectable		 1dm8A-3k77A:
15.32
1dm8B-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 7 SER A 133
PHE A 142
VAL A 131
ALA A  35
 None
 1.06A 1fo4B-3k77A:
undetectable		 1fo4B-3k77A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOP_A_H4BA1600_1
(NITRIC-OXIDE
SYNTHASE)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.42A 1fopA-3k77A:
undetectable
1fopB-3k77A:
undetectable		 1fopA-3k77A:
15.32
1fopB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSE_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.45A 1nseA-3k77A:
undetectable
1nseB-3k77A:
undetectable		 1nseA-3k77A:
15.32
1nseB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6L_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.47A 1p6lA-3k77A:
undetectable
1p6lB-3k77A:
undetectable		 1p6lA-3k77A:
17.14
1p6lB-3k77A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6L_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.47A 1p6lA-3k77A:
undetectable
1p6lB-3k77A:
undetectable		 1p6lA-3k77A:
17.14
1p6lB-3k77A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6M_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.47A 1p6mA-3k77A:
undetectable
1p6mB-3k77A:
undetectable		 1p6mA-3k77A:
17.14
1p6mB-3k77A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6N_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.46A 1p6nA-3k77A:
undetectable
1p6nB-3k77A:
undetectable		 1p6nA-3k77A:
17.14
1p6nB-3k77A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q2O_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.46A 1q2oA-3k77A:
undetectable
1q2oB-3k77A:
undetectable		 1q2oA-3k77A:
16.47
1q2oB-3k77A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q2O_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.48A 1q2oA-3k77A:
undetectable
1q2oB-3k77A:
undetectable		 1q2oA-3k77A:
16.47
1q2oB-3k77A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS8_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.48A 1rs8A-3k77A:
undetectable
1rs8B-3k77A:
undetectable		 1rs8A-3k77A:
16.71
1rs8B-3k77A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS8_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.44A 1rs8A-3k77A:
0.0
1rs8B-3k77A:
0.0		 1rs8A-3k77A:
16.71
1rs8B-3k77A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS9_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.49A 1rs9A-3k77A:
undetectable
1rs9B-3k77A:
undetectable		 1rs9A-3k77A:
16.71
1rs9B-3k77A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS9_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.43A 1rs9A-3k77A:
undetectable
1rs9B-3k77A:
undetectable		 1rs9A-3k77A:
16.71
1rs9B-3k77A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		5 / 11 GLY A  73
ASP A 126
VAL A  10
GLY A  78
VAL A  46
 None
 0.89A 1t7jA-3k77A:
undetectable		 1t7jA-3k77A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZS_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.43A 1zzsA-3k77A:
undetectable
1zzsB-3k77A:
undetectable		 1zzsA-3k77A:
16.47
1zzsB-3k77A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZS_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.48A 1zzsA-3k77A:
undetectable
1zzsB-3k77A:
undetectable		 1zzsA-3k77A:
16.47
1zzsB-3k77A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 7 GLY A  64
PHE A 142
PRO A 141
ASP A 139
 None
 1.17A 2aouB-3k77A:
undetectable		 2aouB-3k77A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HX2_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.48A 2hx2A-3k77A:
undetectable
2hx2B-3k77A:
undetectable		 2hx2A-3k77A:
16.71
2hx2B-3k77A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HX2_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.48A 2hx2A-3k77A:
undetectable
2hx2B-3k77A:
undetectable		 2hx2A-3k77A:
16.71
2hx2B-3k77A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSE_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.48A 2nseA-3k77A:
undetectable
2nseB-3k77A:
undetectable		 2nseA-3k77A:
15.32
2nseB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		5 / 11 CYH A 132
ILE A  60
PHE A  93
SER A  65
PHE A 111
 None
 1.29A 3a9eB-3k77A:
undetectable		 3a9eB-3k77A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		5 / 11 ILE A  60
PHE A  93
SER A  65
PHE A 111
VAL A 117
 None
 1.10A 3a9eB-3k77A:
undetectable		 3a9eB-3k77A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQS_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.47A 3dqsA-3k77A:
undetectable
3dqsB-3k77A:
undetectable		 3dqsA-3k77A:
16.71
3dqsB-3k77A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.49A 3dqtA-3k77A:
undetectable
3dqtB-3k77A:
undetectable		 3dqtA-3k77A:
16.71
3dqtB-3k77A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWX_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.39A 3jwxA-3k77A:
undetectable
3jwxB-3k77A:
undetectable		 3jwxA-3k77A:
15.32
3jwxB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWX_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.43A 3jwxA-3k77A:
0.0
3jwxB-3k77A:
0.0		 3jwxA-3k77A:
15.32
3jwxB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.45A 3jwyA-3k77A:
undetectable
3jwyB-3k77A:
undetectable		 3jwyA-3k77A:
15.32
3jwyB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.45A 3jwyA-3k77A:
0.0
3jwyB-3k77A:
0.0		 3jwyA-3k77A:
15.32
3jwyB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWZ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.45A 3jwzA-3k77A:
undetectable
3jwzB-3k77A:
undetectable		 3jwzA-3k77A:
15.32
3jwzB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Q_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.46A 3n5qA-3k77A:
0.0
3n5qB-3k77A:
0.0		 3n5qA-3k77A:
15.32
3n5qB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5R_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.50A 3n5rA-3k77A:
undetectable
3n5rB-3k77A:
undetectable		 3n5rA-3k77A:
15.32
3n5rB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5R_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.46A 3n5rA-3k77A:
undetectable
3n5rB-3k77A:
undetectable		 3n5rA-3k77A:
15.32
3n5rB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5S_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.44A 3n5sA-3k77A:
undetectable
3n5sB-3k77A:
undetectable		 3n5sA-3k77A:
15.32
3n5sB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5S_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.45A 3n5sA-3k77A:
undetectable
3n5sB-3k77A:
undetectable		 3n5sA-3k77A:
15.32
3n5sB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.45A 3n5tA-3k77A:
undetectable
3n5tB-3k77A:
undetectable		 3n5tA-3k77A:
15.32
3n5tB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6E_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.47A 3n6eA-3k77A:
undetectable
3n6eB-3k77A:
undetectable		 3n6eA-3k77A:
15.32
3n6eB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6E_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.47A 3n6eA-3k77A:
undetectable
3n6eB-3k77A:
undetectable		 3n6eA-3k77A:
15.32
3n6eB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6F_A_H4BA600_1
('NITRIC OXIDE
SYNTHASE)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.43A 3n6fA-3k77A:
undetectable
3n6fB-3k77A:
undetectable		 3n6fA-3k77A:
15.32
3n6fB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6F_B_H4BB600_1
('NITRIC OXIDE
SYNTHASE)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.45A 3n6fA-3k77A:
undetectable
3n6fB-3k77A:
undetectable		 3n6fA-3k77A:
15.32
3n6fB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6G_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.46A 3n6gA-3k77A:
undetectable
3n6gB-3k77A:
undetectable		 3n6gA-3k77A:
15.32
3n6gB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6G_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.45A 3n6gA-3k77A:
undetectable
3n6gB-3k77A:
undetectable		 3n6gA-3k77A:
15.32
3n6gB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLE_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.41A 3nleA-3k77A:
0.0
3nleB-3k77A:
0.0		 3nleA-3k77A:
15.32
3nleB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLE_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.46A 3nleA-3k77A:
undetectable
3nleB-3k77A:
undetectable		 3nleA-3k77A:
15.32
3nleB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLF_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.42A 3nlfA-3k77A:
undetectable
3nlfB-3k77A:
undetectable		 3nlfA-3k77A:
15.32
3nlfB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLG_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.43A 3nlgA-3k77A:
undetectable
3nlgB-3k77A:
undetectable		 3nlgA-3k77A:
15.32
3nlgB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLG_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.44A 3nlgA-3k77A:
undetectable
3nlgB-3k77A:
undetectable		 3nlgA-3k77A:
15.32
3nlgB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLH_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.44A 3nlhA-3k77A:
undetectable
3nlhB-3k77A:
undetectable		 3nlhA-3k77A:
15.32
3nlhB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLH_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.45A 3nlhA-3k77A:
undetectable
3nlhB-3k77A:
undetectable		 3nlhA-3k77A:
15.32
3nlhB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLI_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.44A 3nliA-3k77A:
0.0
3nliB-3k77A:
0.0		 3nliA-3k77A:
15.32
3nliB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLI_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.47A 3nliA-3k77A:
0.0
3nliB-3k77A:
0.0		 3nliA-3k77A:
15.32
3nliB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLU_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.48A 3nluA-3k77A:
undetectable
3nluB-3k77A:
undetectable		 3nluA-3k77A:
15.32
3nluB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NOS_A_H4BA511_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.42A 3nosA-3k77A:
0.0
3nosB-3k77A:
0.0		 3nosA-3k77A:
16.28
3nosB-3k77A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNH_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.44A 3pnhA-3k77A:
0.0
3pnhB-3k77A:
0.0		 3pnhA-3k77A:
16.71
3pnhB-3k77A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNH_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.45A 3pnhA-3k77A:
0.0
3pnhB-3k77A:
0.0		 3pnhA-3k77A:
16.71
3pnhB-3k77A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQO_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.38A 3rqoA-3k77A:
0.0
3rqoB-3k77A:
0.0		 3rqoA-3k77A:
15.35
3rqoB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQO_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.49A 3rqoA-3k77A:
undetectable
3rqoB-3k77A:
undetectable		 3rqoA-3k77A:
15.35
3rqoB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQP_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.43A 3rqpA-3k77A:
undetectable
3rqpB-3k77A:
undetectable		 3rqpA-3k77A:
15.35
3rqpB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C3A_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.42A 4c3aA-3k77A:
undetectable
4c3aB-3k77A:
undetectable		 4c3aA-3k77A:
15.35
4c3aB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C3A_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.44A 4c3aA-3k77A:
undetectable
4c3aB-3k77A:
undetectable		 4c3aA-3k77A:
15.35
4c3aB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAR_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.48A 4carA-3k77A:
undetectable
4carB-3k77A:
undetectable		 4carA-3k77A:
15.35
4carB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAR_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.45A 4carA-3k77A:
undetectable
4carB-3k77A:
undetectable		 4carA-3k77A:
15.35
4carB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CFT_A_H4BA600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.47A 4cftA-3k77A:
undetectable
4cftB-3k77A:
undetectable		 4cftA-3k77A:
15.35
4cftB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CFT_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.48A 4cftA-3k77A:
undetectable
4cftB-3k77A:
undetectable		 4cftA-3k77A:
15.35
4cftB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.43A 4ctyA-3k77A:
undetectable
4ctyB-3k77A:
undetectable		 4ctyA-3k77A:
15.35
4ctyB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.46A 4ctyA-3k77A:
undetectable
4ctyB-3k77A:
undetectable		 4ctyA-3k77A:
15.35
4ctyB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTZ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.48A 4ctzA-3k77A:
undetectable
4ctzB-3k77A:
undetectable		 4ctzA-3k77A:
15.35
4ctzB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTZ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.47A 4ctzA-3k77A:
0.0
4ctzB-3k77A:
0.0		 4ctzA-3k77A:
15.35
4ctzB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU0_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.41A 4cu0A-3k77A:
undetectable
4cu0B-3k77A:
undetectable		 4cu0A-3k77A:
15.35
4cu0B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU0_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.41A 4cu0A-3k77A:
undetectable
4cu0B-3k77A:
undetectable		 4cu0A-3k77A:
15.35
4cu0B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU1_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.46A 4cu1A-3k77A:
undetectable
4cu1B-3k77A:
undetectable		 4cu1A-3k77A:
15.35
4cu1B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU1_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.47A 4cu1A-3k77A:
undetectable
4cu1B-3k77A:
undetectable		 4cu1A-3k77A:
15.35
4cu1B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWV_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.41A 4cwvA-3k77A:
undetectable
4cwvB-3k77A:
undetectable		 4cwvA-3k77A:
15.35
4cwvB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWW_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.42A 4cwwA-3k77A:
undetectable
4cwwB-3k77A:
undetectable		 4cwwA-3k77A:
15.35
4cwwB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWW_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.45A 4cwwA-3k77A:
undetectable
4cwwB-3k77A:
undetectable		 4cwwA-3k77A:
15.35
4cwwB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWX_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.38A 4cwxA-3k77A:
undetectable
4cwxB-3k77A:
undetectable		 4cwxA-3k77A:
15.35
4cwxB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWX_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 7 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.42A 4cwxA-3k77A:
undetectable
4cwxB-3k77A:
undetectable		 4cwxA-3k77A:
15.35
4cwxB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 7 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.41A 4cwyA-3k77A:
undetectable
4cwyB-3k77A:
undetectable		 4cwyA-3k77A:
15.35
4cwyB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 7 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.41A 4cwyA-3k77A:
undetectable
4cwyB-3k77A:
undetectable		 4cwyA-3k77A:
15.35
4cwyB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWZ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.43A 4cwzA-3k77A:
undetectable
4cwzB-3k77A:
undetectable		 4cwzA-3k77A:
15.35
4cwzB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWZ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.45A 4cwzA-3k77A:
undetectable
4cwzB-3k77A:
undetectable		 4cwzA-3k77A:
15.35
4cwzB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX0_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.43A 4cx0A-3k77A:
undetectable
4cx0B-3k77A:
undetectable		 4cx0A-3k77A:
15.35
4cx0B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX0_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.47A 4cx0A-3k77A:
undetectable
4cx0B-3k77A:
undetectable		 4cx0A-3k77A:
15.35
4cx0B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1O_B_H4BB1481_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.50A 4d1oA-3k77A:
undetectable
4d1oB-3k77A:
undetectable		 4d1oA-3k77A:
15.58
4d1oB-3k77A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1P_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.45A 4d1pA-3k77A:
undetectable
4d1pB-3k77A:
undetectable		 4d1pA-3k77A:
15.58
4d1pB-3k77A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D34_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.44A 4d34A-3k77A:
undetectable
4d34B-3k77A:
undetectable		 4d34A-3k77A:
15.35
4d34B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D35_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.43A 4d35A-3k77A:
0.0
4d35B-3k77A:
0.0		 4d35A-3k77A:
15.35
4d35B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D36_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.42A 4d36A-3k77A:
undetectable
4d36B-3k77A:
undetectable		 4d36A-3k77A:
15.35
4d36B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D36_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.44A 4d36A-3k77A:
undetectable
4d36B-3k77A:
undetectable		 4d36A-3k77A:
15.35
4d36B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D37_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.47A 4d37A-3k77A:
undetectable
4d37B-3k77A:
undetectable		 4d37A-3k77A:
15.35
4d37B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D37_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.44A 4d37A-3k77A:
undetectable
4d37B-3k77A:
undetectable		 4d37A-3k77A:
15.35
4d37B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D38_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.44A 4d38A-3k77A:
undetectable
4d38B-3k77A:
undetectable		 4d38A-3k77A:
15.35
4d38B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.44A 4d39A-3k77A:
undetectable
4d39B-3k77A:
undetectable		 4d39A-3k77A:
15.35
4d39B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.47A 4d39A-3k77A:
undetectable
4d39B-3k77A:
undetectable		 4d39A-3k77A:
15.35
4d39B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		5 / 12 GLY A 143
ASN A  62
ILE A  43
VAL A   9
ILE A 130
 None
 1.28A 4fglA-3k77A:
undetectable
4fglB-3k77A:
undetectable		 4fglA-3k77A:
19.40
4fglB-3k77A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMX_A_H4BA502_1
(SUBUNIT A)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.44A 4imxA-3k77A:
undetectable
4imxB-3k77A:
undetectable		 4imxA-3k77A:
15.38
4imxB-3k77A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMX_B_H4BB502_1
(SUBUNIT A)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.46A 4imxA-3k77A:
0.0
4imxB-3k77A:
0.0		 4imxA-3k77A:
15.38
4imxB-3k77A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSK_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.42A 4jskA-3k77A:
undetectable
4jskB-3k77A:
undetectable		 4jskA-3k77A:
15.35
4jskB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSL_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.44A 4jslA-3k77A:
undetectable
4jslB-3k77A:
undetectable		 4jslA-3k77A:
15.35
4jslB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSL_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.47A 4jslA-3k77A:
0.0
4jslB-3k77A:
0.0		 4jslA-3k77A:
15.35
4jslB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSM_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.42A 4jsmA-3k77A:
undetectable
4jsmB-3k77A:
undetectable		 4jsmA-3k77A:
15.35
4jsmB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSM_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.44A 4jsmA-3k77A:
undetectable
4jsmB-3k77A:
undetectable		 4jsmA-3k77A:
15.35
4jsmB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5H_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.43A 4k5hA-3k77A:
undetectable
4k5hB-3k77A:
undetectable		 4k5hA-3k77A:
15.35
4k5hB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5H_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.46A 4k5hA-3k77A:
undetectable
4k5hB-3k77A:
undetectable		 4k5hA-3k77A:
15.35
4k5hB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5I_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.45A 4k5iA-3k77A:
undetectable
4k5iB-3k77A:
undetectable		 4k5iA-3k77A:
15.35
4k5iB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5I_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.47A 4k5iA-3k77A:
undetectable
4k5iB-3k77A:
undetectable		 4k5iA-3k77A:
15.35
4k5iB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.45A 4k5jA-3k77A:
undetectable
4k5jB-3k77A:
undetectable		 4k5jA-3k77A:
15.35
4k5jB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5K_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.47A 4k5kA-3k77A:
undetectable
4k5kB-3k77A:
undetectable		 4k5kA-3k77A:
15.35
4k5kB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5K_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.47A 4k5kA-3k77A:
undetectable
4k5kB-3k77A:
undetectable		 4k5kA-3k77A:
15.35
4k5kB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCP_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.41A 4kcpA-3k77A:
undetectable
4kcpB-3k77A:
undetectable		 4kcpA-3k77A:
15.35
4kcpB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCP_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.44A 4kcpA-3k77A:
undetectable
4kcpB-3k77A:
undetectable		 4kcpA-3k77A:
15.35
4kcpB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCQ_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.43A 4kcqA-3k77A:
undetectable
4kcqB-3k77A:
undetectable		 4kcqA-3k77A:
15.35
4kcqB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCQ_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.46A 4kcqA-3k77A:
undetectable
4kcqB-3k77A:
undetectable		 4kcqA-3k77A:
15.35
4kcqB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCR_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.46A 4kcrA-3k77A:
undetectable
4kcrB-3k77A:
undetectable		 4kcrA-3k77A:
15.35
4kcrB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCR_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.47A 4kcrA-3k77A:
undetectable
4kcrB-3k77A:
undetectable		 4kcrA-3k77A:
15.35
4kcrB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCS_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.45A 4kcsA-3k77A:
undetectable
4kcsB-3k77A:
undetectable		 4kcsA-3k77A:
15.35
4kcsB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCS_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.46A 4kcsA-3k77A:
undetectable
4kcsB-3k77A:
undetectable		 4kcsA-3k77A:
15.35
4kcsB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUW_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.44A 4luwA-3k77A:
undetectable
4luwB-3k77A:
undetectable		 4luwA-3k77A:
15.38
4luwB-3k77A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUW_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.47A 4luwA-3k77A:
0.0
4luwB-3k77A:
0.0		 4luwA-3k77A:
15.38
4luwB-3k77A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.44A 4uh7A-3k77A:
undetectable
4uh7B-3k77A:
undetectable		 4uh7A-3k77A:
15.35
4uh7B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.50A 4uh7A-3k77A:
0.0
4uh7B-3k77A:
0.0		 4uh7A-3k77A:
15.35
4uh7B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH8_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.45A 4uh8A-3k77A:
undetectable
4uh8B-3k77A:
undetectable		 4uh8A-3k77A:
15.35
4uh8B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH8_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.46A 4uh8A-3k77A:
undetectable
4uh8B-3k77A:
undetectable		 4uh8A-3k77A:
15.35
4uh8B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH9_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.41A 4uh9A-3k77A:
undetectable
4uh9B-3k77A:
undetectable		 4uh9A-3k77A:
15.35
4uh9B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH9_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.46A 4uh9A-3k77A:
undetectable
4uh9B-3k77A:
undetectable		 4uh9A-3k77A:
15.35
4uh9B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHA_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.44A 4uhaA-3k77A:
undetectable
4uhaB-3k77A:
undetectable		 4uhaA-3k77A:
15.35
4uhaB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHA_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.49A 4uhaA-3k77A:
undetectable
4uhaB-3k77A:
undetectable		 4uhaA-3k77A:
15.35
4uhaB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPQ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.45A 4upqA-3k77A:
undetectable
4upqB-3k77A:
undetectable		 4upqA-3k77A:
15.35
4upqB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPQ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.44A 4upqA-3k77A:
undetectable
4upqB-3k77A:
undetectable		 4upqA-3k77A:
15.35
4upqB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPR_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.44A 4uprA-3k77A:
undetectable
4uprB-3k77A:
undetectable		 4uprA-3k77A:
15.35
4uprB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPR_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.45A 4uprA-3k77A:
undetectable
4uprB-3k77A:
undetectable		 4uprA-3k77A:
15.35
4uprB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPS_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.47A 4upsA-3k77A:
undetectable
4upsB-3k77A:
undetectable		 4upsA-3k77A:
15.35
4upsB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPS_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.46A 4upsA-3k77A:
undetectable
4upsB-3k77A:
undetectable		 4upsA-3k77A:
15.35
4upsB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPT_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.48A 4uptA-3k77A:
undetectable
4uptB-3k77A:
undetectable		 4uptA-3k77A:
15.35
4uptB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPT_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.46A 4uptA-3k77A:
undetectable
4uptB-3k77A:
undetectable		 4uptA-3k77A:
15.35
4uptB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADJ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.46A 5adjA-3k77A:
undetectable
5adjB-3k77A:
undetectable		 5adjA-3k77A:
15.35
5adjB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADJ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.46A 5adjA-3k77A:
undetectable
5adjB-3k77A:
undetectable		 5adjA-3k77A:
15.35
5adjB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADK_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.46A 5adkA-3k77A:
undetectable
5adkB-3k77A:
undetectable		 5adkA-3k77A:
15.35
5adkB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADK_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.47A 5adkA-3k77A:
undetectable
5adkB-3k77A:
undetectable		 5adkA-3k77A:
15.35
5adkB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 7 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.45A 5adlA-3k77A:
undetectable
5adlB-3k77A:
undetectable		 5adlA-3k77A:
15.35
5adlB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADM_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.44A 5admA-3k77A:
undetectable
5admB-3k77A:
undetectable		 5admA-3k77A:
15.35
5admB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADM_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.44A 5admA-3k77A:
undetectable
5admB-3k77A:
undetectable		 5admA-3k77A:
15.35
5admB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADN_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.48A 5adnA-3k77A:
undetectable
5adnB-3k77A:
undetectable		 5adnA-3k77A:
15.35
5adnB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ2_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.49A 5fj2A-3k77A:
undetectable
5fj2B-3k77A:
undetectable		 5fj2A-3k77A:
15.35
5fj2B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ2_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.47A 5fj2A-3k77A:
undetectable
5fj2B-3k77A:
undetectable		 5fj2A-3k77A:
15.35
5fj2B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.49A 5fj3A-3k77A:
undetectable
5fj3B-3k77A:
undetectable		 5fj3A-3k77A:
15.35
5fj3B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.47A 5fvyA-3k77A:
undetectable
5fvyB-3k77A:
undetectable		 5fvyA-3k77A:
15.35
5fvyB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVZ_A_H4BA600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.47A 5fvzA-3k77A:
undetectable
5fvzB-3k77A:
undetectable		 5fvzA-3k77A:
15.35
5fvzB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVZ_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.46A 5fvzA-3k77A:
undetectable
5fvzB-3k77A:
undetectable		 5fvzA-3k77A:
15.35
5fvzB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		3 / 3 LYS A  32
TRP A  33
SER A 145
 None
 1.36A 5nwwA-3k77A:
undetectable		 5nwwA-3k77A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.43A 5uo8C-3k77A:
undetectable
5uo8D-3k77A:
undetectable		 5uo8C-3k77A:
15.58
5uo8D-3k77A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.49A 5uo9A-3k77A:
0.0
5uo9B-3k77A:
0.0		 5uo9A-3k77A:
15.58
5uo9B-3k77A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 7 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.43A 5uo9A-3k77A:
undetectable
5uo9B-3k77A:
undetectable		 5uo9A-3k77A:
15.58
5uo9B-3k77A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.45A 5uo9C-3k77A:
undetectable
5uo9D-3k77A:
undetectable		 5uo9C-3k77A:
15.58
5uo9D-3k77A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UOD_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.47A 5uodA-3k77A:
undetectable
5uodB-3k77A:
undetectable		 5uodA-3k77A:
15.35
5uodB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UOD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.48A 5uodA-3k77A:
undetectable
5uodB-3k77A:
undetectable		 5uodA-3k77A:
15.35
5uodB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV6_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.44A 5vv6A-3k77A:
undetectable
5vv6B-3k77A:
undetectable		 5vv6A-3k77A:
15.35
5vv6B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV6_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.44A 5vv6A-3k77A:
0.0
5vv6B-3k77A:
0.0		 5vv6A-3k77A:
15.35
5vv6B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.48A 5vv7A-3k77A:
undetectable
5vv7B-3k77A:
undetectable		 5vv7A-3k77A:
15.35
5vv7B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 7 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.47A 5vv7A-3k77A:
undetectable
5vv7B-3k77A:
undetectable		 5vv7A-3k77A:
15.35
5vv7B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.46A 5vv8A-3k77A:
undetectable
5vv8B-3k77A:
undetectable		 5vv8A-3k77A:
15.35
5vv8B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV8_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.44A 5vv8A-3k77A:
undetectable
5vv8B-3k77A:
undetectable		 5vv8A-3k77A:
15.35
5vv8B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 7 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.45A 5vv9A-3k77A:
undetectable
5vv9B-3k77A:
undetectable		 5vv9A-3k77A:
15.35
5vv9B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVB_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.38A 5vvbA-3k77A:
undetectable
5vvbB-3k77A:
undetectable		 5vvbA-3k77A:
15.58
5vvbB-3k77A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVB_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.45A 5vvbC-3k77A:
0.0
5vvbD-3k77A:
0.0		 5vvbC-3k77A:
15.58
5vvbD-3k77A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVC_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.44A 5vvcA-3k77A:
undetectable
5vvcB-3k77A:
undetectable		 5vvcA-3k77A:
15.58
5vvcB-3k77A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVC_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.42A 5vvcC-3k77A:
undetectable
5vvcD-3k77A:
undetectable		 5vvcC-3k77A:
15.58
5vvcD-3k77A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVC_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.50A 5vvcC-3k77A:
undetectable
5vvcD-3k77A:
undetectable		 5vvcC-3k77A:
15.58
5vvcD-3k77A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 7 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.45A 5vvdA-3k77A:
undetectable
5vvdB-3k77A:
undetectable		 5vvdA-3k77A:
15.58
5vvdB-3k77A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.43A 5vvdC-3k77A:
undetectable
5vvdD-3k77A:
undetectable		 5vvdC-3k77A:
15.58
5vvdD-3k77A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVG_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.44A 5vvgA-3k77A:
undetectable
5vvgB-3k77A:
undetectable		 5vvgA-3k77A:
15.35
5vvgB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVG_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.45A 5vvgA-3k77A:
0.0
5vvgB-3k77A:
0.0		 5vvgA-3k77A:
15.35
5vvgB-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		5 / 12 VAL A  46
VAL A  72
GLY A  73
PHE A 149
VAL A 147
 None
 1.10A 6a94B-3k77A:
undetectable		 6a94B-3k77A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 7 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.46A 6av6A-3k77A:
undetectable
6av6B-3k77A:
undetectable		 6av6A-3k77A:
20.00
6av6B-3k77A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 7 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.46A 6av7A-3k77A:
undetectable
6av7B-3k77A:
undetectable		 6av7A-3k77A:
20.00
6av7B-3k77A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.49A 6av7A-3k77A:
undetectable
6av7B-3k77A:
undetectable		 6av7A-3k77A:
20.00
6av7B-3k77A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.48A 6av7C-3k77A:
0.0
6av7D-3k77A:
0.0		 6av7C-3k77A:
20.00
6av7D-3k77A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.49A 6cifA-3k77A:
undetectable
6cifB-3k77A:
undetectable		 6cifA-3k77A:
20.00
6cifB-3k77A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
8NSE_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.49A 8nseA-3k77A:
undetectable
8nseB-3k77A:
undetectable		 8nseA-3k77A:
15.32
8nseB-3k77A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9NSE_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens) 		4 / 6 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.47A 9nseA-3k77A:
undetectable
9nseB-3k77A:
undetectable		 9nseA-3k77A:
15.32
9nseB-3k77A:
15.32