SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k7h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 3k7h INDIAN HEDGEHOG
PROTEIN
(Homo
sapiens) 		5 / 12 LEU B 111
ASN B 112
LEU B 114
ALA B 115
MET B 103
 None
 1.13A 1ya3C-3k7hB:
undetectable		 1ya3C-3k7hB:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 3k7h INDIAN HEDGEHOG
PROTEIN
(Homo
sapiens) 		5 / 12 LEU B 111
ASN B 112
LEU B 114
ALA B 115
MET B 103
 None
 1.15A 2aa6A-3k7hB:
undetectable		 2aa6A-3k7hB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3k7h INDIAN HEDGEHOG
PROTEIN
(Homo
sapiens) 		3 / 3 HIS B 145
SER B  64
GLU B  58
 ZN  B1001 (-3.2A)
None
None
 0.68A 3s8pA-3k7hB:
undetectable		 3s8pA-3k7hB:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 3k7h INDIAN HEDGEHOG
PROTEIN
(Homo
sapiens) 		5 / 12 LEU B 111
ASN B 112
LEU B 114
ALA B 115
MET B 103
 None
 1.10A 4fn9B-3k7hB:
undetectable		 4fn9B-3k7hB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3k7h INDIAN HEDGEHOG
PROTEIN
(Homo
sapiens) 		4 / 6 SER B  53
GLN B  51
VAL B  45
ARG B 168
 None
 1.34A 4lnxA-3k7hB:
undetectable		 4lnxA-3k7hB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 3k7h INDIAN HEDGEHOG
PROTEIN
(Homo
sapiens) 		3 / 3 LYS B  95
ARG B 128
VAL B 129
 None
SO4  B   1 (-3.0A)
None
 1.04A 4x3uA-3k7hB:
undetectable
4x3uB-3k7hB:
undetectable		 4x3uA-3k7hB:
17.22
4x3uB-3k7hB:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 3k7h INDIAN HEDGEHOG
PROTEIN
(Homo
sapiens) 		5 / 12 VAL B 186
ASN B 161
GLY B 164
ALA B 167
LEU B 114
 None
 1.10A 5xxiA-3k7hB:
undetectable		 5xxiA-3k7hB:
19.08