SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k7t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		5 / 10 GLU A 296
ALA A 297
LEU A 348
GLU A 350
GLU A 352
 None
 1.01A 1a29A-3k7tA:
undetectable		 1a29A-3k7tA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		3 / 3 ARG A 273
ILE A 263
TRP A 260
 None
 1.10A 1nodB-3k7tA:
undetectable		 1nodB-3k7tA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		5 / 10 LEU A 323
ILE A 337
GLY A 338
VAL A 292
ILE A 290
 None
 0.82A 1sdtA-3k7tA:
undetectable		 1sdtA-3k7tA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		5 / 12 GLY A  13
PHE A  11
VAL A 396
ALA A  16
ARG A  18
 None
 1.21A 2avdB-3k7tA:
undetectable		 2avdB-3k7tA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_1
(POL POLYPROTEIN)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		5 / 12 LEU A 323
ILE A 337
GLY A 338
VAL A 292
ILE A 290
 None
 0.82A 2avvA-3k7tA:
undetectable		 2avvA-3k7tA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		4 / 7 ASP A 312
ARG A  89
LEU A 348
GLU A 350
 None
 1.11A 2cdqB-3k7tA:
undetectable		 2cdqB-3k7tA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		4 / 6 LEU A 168
VAL A 111
VAL A 147
ILE A 191
 None
None
None
GP7  A 435 (-4.6A)
 0.97A 2hyyA-3k7tA:
undetectable		 2hyyA-3k7tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		3 / 3 ARG A 273
ILE A 263
TRP A 260
 None
 1.08A 2nodB-3k7tA:
undetectable		 2nodB-3k7tA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		5 / 12 LEU A 323
ILE A 337
GLY A 338
VAL A 292
ILE A 290
 None
 0.80A 2r5pA-3k7tA:
undetectable		 2r5pA-3k7tA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		5 / 12 LEU A 323
ILE A 337
GLY A 338
VAL A 292
ILE A 290
 None
 0.79A 2r5pC-3k7tA:
undetectable		 2r5pC-3k7tA:
13.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		5 / 7 ASN A 166
MET A 167
LEU A 183
PHE A 326
TRP A 371
 None
 0.18A 3nk2X-3k7tA:
64.7		 3nk2X-3k7tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		5 / 7 MET A 167
LEU A 183
LEU A 198
PHE A 326
TRP A 371
 None
 0.75A 3nk2X-3k7tA:
64.7		 3nk2X-3k7tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		5 / 7 TYR A  59
MET A 167
LEU A 183
LEU A 198
TRP A 371
 None
 0.82A 3nk2X-3k7tA:
64.7		 3nk2X-3k7tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NN0_X_NCAX433_0
(6-HYDROXY-L-NICOTINE
OXIDASE)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		7 / 9 TYR A  59
ASN A 166
MET A 167
LEU A 183
PHE A 326
TRP A 371
GLY A 406
 None
None
None
None
None
None
FAD  A 434 (-4.3A)
 0.65A 3nn0X-3k7tA:
64.4		 3nn0X-3k7tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NN0_X_NCAX433_0
(6-HYDROXY-L-NICOTINE
OXIDASE)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		7 / 9 TYR A  59
ASN A 166
MET A 167
PHE A 326
TRP A 371
GLY A 406
TYR A 407
 None
None
None
None
None
FAD  A 434 (-4.3A)
FAD  A 434 (-4.3A)
 0.78A 3nn0X-3k7tA:
64.4		 3nn0X-3k7tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NN0_X_NCAX433_0
(6-HYDROXY-L-NICOTINE
OXIDASE)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		7 / 9 TYR A  59
MET A 167
LEU A 183
LEU A 198
PHE A 326
TRP A 371
GLY A 406
 None
None
None
None
None
None
FAD  A 434 (-4.3A)
 0.81A 3nn0X-3k7tA:
64.4		 3nn0X-3k7tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NN0_X_NCAX433_0
(6-HYDROXY-L-NICOTINE
OXIDASE)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		7 / 9 TYR A  59
MET A 167
LEU A 198
PHE A 326
TRP A 371
GLY A 406
TYR A 407
 None
None
None
None
None
FAD  A 434 (-4.3A)
FAD  A 434 (-4.3A)
 0.87A 3nn0X-3k7tA:
64.4		 3nn0X-3k7tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		4 / 8 ALA A 343
TRP A 165
GLY A 169
PRO A 171
 None
 0.95A 3ny4A-3k7tA:
undetectable		 3ny4A-3k7tA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		5 / 9 HIS A 383
LEU A 131
PRO A 374
LEU A 178
LEU A 183
 None
 1.25A 3q1eB-3k7tA:
undetectable
3q1eD-3k7tA:
undetectable		 3q1eB-3k7tA:
13.35
3q1eD-3k7tA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		5 / 12 ILE A 252
GLY A   8
ILE A 220
ASN A  22
LEU A  14
 None
FAD  A 434 (-3.2A)
None
None
None
 1.23A 4a81A-3k7tA:
undetectable		 4a81A-3k7tA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		4 / 7 LEU A 198
TYR A 407
HIS A  64
HIS A 187
 None
FAD  A 434 (-4.3A)
None
None
 1.17A 4arcA-3k7tA:
undetectable		 4arcA-3k7tA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		5 / 11 ARG A 274
ALA A 268
LEU A 269
ILE A 422
LEU A  20
 None
 0.94A 4kt0A-3k7tA:
undetectable
4kt0J-3k7tA:
undetectable		 4kt0A-3k7tA:
18.73
4kt0J-3k7tA:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		4 / 7 VAL A 276
PHE A 379
HIS A 383
GLU A 385
 None
 1.28A 5ad9A-3k7tA:
undetectable
5ad9B-3k7tA:
undetectable		 5ad9A-3k7tA:
20.21
5ad9B-3k7tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		5 / 12 GLY A  13
LEU A  36
SER A 214
ILE A 217
VAL A   6
 None
 1.08A 5dpdA-3k7tA:
undetectable		 5dpdA-3k7tA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		4 / 8 HIS A 187
GLY A 193
VAL A 195
SER A 197
 None
None
GP7  A 435 (-4.7A)
None
 0.89A 5m8rC-3k7tA:
undetectable		 5m8rC-3k7tA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		6 / 12 LEU A  72
ALA A  70
ILE A  77
GLY A  76
LEU A  68
LEU A 412
 None
 1.17A 5nfjA-3k7tA:
2.6		 5nfjA-3k7tA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		5 / 10 ARG A 274
ALA A 268
LEU A 269
ILE A 422
LEU A  20
 None
 1.11A 5oy01-3k7tA:
undetectable
5oy07-3k7tA:
undetectable		 5oy01-3k7tA:
11.19
5oy07-3k7tA:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		4 / 5 LEU A 196
LEU A 192
MET A 167
TYR A  59
 GP7  A 435 ( 4.8A)
GP7  A 435 (-4.5A)
None
None
 0.84A 5uc3A-3k7tA:
undetectable		 5uc3A-3k7tA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		5 / 12 GLN A 170
HIS A 281
GLY A 282
VAL A 276
GLY A 285
 None
 1.03A 6c2mA-3k7tA:
undetectable		 6c2mA-3k7tA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		5 / 12 GLN A 170
HIS A 281
GLY A 282
VAL A 276
GLY A 285
 None
 1.11A 6c2mB-3k7tA:
undetectable		 6c2mB-3k7tA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		5 / 9 VAL A 226
GLY A  13
LEU A  29
THR A 255
VAL A 253
 FAD  A 434 (-3.9A)
None
None
FAD  A 434 (-4.0A)
None
 1.30A 6czmB-3k7tA:
2.2
6czmC-3k7tA:
undetectable		 6czmB-3k7tA:
22.33
6czmC-3k7tA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		5 / 9 VAL A 226
GLY A  13
LEU A  29
THR A 255
VAL A 253
 FAD  A 434 (-3.9A)
None
None
FAD  A 434 (-4.0A)
None
 1.30A 6czmD-3k7tA:
2.2
6czmE-3k7tA:
undetectable		 6czmD-3k7tA:
22.33
6czmE-3k7tA:
22.33