SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k7u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
3k7u ANTIBODY
(Lama
glama)
5 / 12 GLN A 101
GLY A 102
GLY A  35
THR A 106
ALA A 107
None
1.07A 1jg4A-3k7uA:
undetectable
1jg4A-3k7uA:
20.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)
3k7u ANTIBODY
(Lama
glama)
6 / 12 LEU A   4
ALA A  24
ARG A  72
VAL A  79
ALA A  98
TYR A 111
None
0.69A 3qxtB-3k7uA:
22.5
3qxtB-3k7uA:
73.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)
3k7u ANTIBODY
(Lama
glama)
6 / 12 LEU A   4
MET A  34
ARG A  72
VAL A  79
ALA A  98
TYR A 111
None
0.33A 3qxtB-3k7uA:
22.5
3qxtB-3k7uA:
73.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)
3k7u ANTIBODY
(Lama
glama)
6 / 12 MET A  34
ARG A  72
ASN A  74
VAL A  79
ALA A  98
TYR A 111
None
0.36A 3qxvA-3k7uA:
22.0
3qxvA-3k7uA:
73.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)
3k7u ANTIBODY
(Lama
glama)
5 / 12 MET A  34
ARG A  72
VAL A  79
ALA A  98
TYR A 111
None
0.47A 3qxvB-3k7uA:
22.2
3qxvB-3k7uA:
73.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)
3k7u ANTIBODY
(Lama
glama)
5 / 11 MET A  34
ARG A  72
ASN A  74
VAL A  79
ALA A  98
None
0.28A 3qxvC-3k7uA:
22.1
3qxvC-3k7uA:
73.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)
3k7u ANTIBODY
(Lama
glama)
5 / 12 MET A  34
ARG A  72
VAL A  79
ALA A  98
TYR A 111
None
0.39A 3qxvD-3k7uA:
21.9
3qxvD-3k7uA:
73.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)
3k7u ANTIBODY
(Lama
glama)
5 / 12 MET A  34
ARG A  72
VAL A  79
ALA A  98
TYR A 111
None
0.51A 3qxvE-3k7uA:
18.7
3qxvE-3k7uA:
73.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA901_0
(PROTEIN ARGONAUTE-2)
3k7u ANTIBODY
(Lama
glama)
4 / 4 PHE A  59
VAL A 105
ALA A  50
PHE A  37
None
1.40A 4f3tA-3k7uA:
undetectable
4f3tA-3k7uA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA904_0
(PROTEIN ARGONAUTE-2)
3k7u ANTIBODY
(Lama
glama)
4 / 4 PHE A  59
VAL A 105
ALA A  50
PHE A  37
None
1.37A 4w5qA-3k7uA:
undetectable
4w5qA-3k7uA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA904_0
(PROTEIN ARGONAUTE-2)
3k7u ANTIBODY
(Lama
glama)
4 / 4 PHE A  59
VAL A 105
ALA A  50
PHE A  37
None
1.41A 4w5rA-3k7uA:
undetectable
4w5rA-3k7uA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA904_0
(PROTEIN ARGONAUTE-2)
3k7u ANTIBODY
(Lama
glama)
4 / 4 PHE A  59
VAL A 105
ALA A  50
PHE A  37
None
1.41A 4w5tA-3k7uA:
undetectable
4w5tA-3k7uA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA904_0
(PROTEIN ARGONAUTE-2)
3k7u ANTIBODY
(Lama
glama)
4 / 4 PHE A  59
VAL A 105
ALA A  50
PHE A  37
None
1.38A 4z4gA-3k7uA:
undetectable
4z4gA-3k7uA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)
3k7u ANTIBODY
(Lama
glama)
4 / 7 ALA A  92
THR A  91
VAL A 118
GLU A  89
None
0.75A 5ecmD-3k7uA:
undetectable
5ecmD-3k7uA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)
3k7u ANTIBODY
(Lama
glama)
4 / 7 ALA A  92
THR A  91
VAL A 118
GLU A  89
None
0.81A 5ecoD-3k7uA:
undetectable
5ecoD-3k7uA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA902_0
(PROTEIN ARGONAUTE-2)
3k7u ANTIBODY
(Lama
glama)
4 / 4 PHE A  59
VAL A 105
ALA A  50
PHE A  37
None
1.37A 5ki6A-3k7uA:
undetectable
5ki6A-3k7uA:
9.88