SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k7y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3k7y ASPARTATE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		4 / 7 LEU A  80
LEU A  84
MET A 251
LEU A 300
 None
 1.05A 1kt3A-3k7yA:
undetectable		 1kt3A-3k7yA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 3k7y ASPARTATE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		4 / 7 ILE A 157
ARG A 380
ILE A 381
PHE A 329
 None
 1.04A 2q6hA-3k7yA:
undetectable		 2q6hA-3k7yA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3k7y ASPARTATE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 VAL A 243
TYR A 286
GLY A 108
ALA A 109
LEU A 113
 None
 0.93A 3hs6A-3k7yA:
undetectable		 3hs6A-3k7yA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3k7y ASPARTATE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 SER A 246
ALA A 215
ILE A 101
ILE A 263
LEU A 113
 PLP  A 406 (-2.8A)
PLP  A 406 ( 3.7A)
None
None
None
 0.89A 3mb5A-3k7yA:
3.0		 3mb5A-3k7yA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 3k7y ASPARTATE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 LEU A 113
GLY A 108
GLY A 106
ILE A 263
ASN A  72
 None
None
PLP  A 406 (-3.4A)
None
None
 1.01A 3nk7A-3k7yA:
undetectable		 3nk7A-3k7yA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 3k7y ASPARTATE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		4 / 8 HIS A 262
ILE A 263
SER A 242
ILE A 211
 None
 1.09A 3sfeB-3k7yA:
undetectable
3sfeC-3k7yA:
undetectable		 3sfeB-3k7yA:
21.17
3sfeC-3k7yA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 3k7y ASPARTATE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 PHE A 234
ALA A 240
PHE A 212
LEU A 230
LEU A 168
 None
 1.23A 4kykA-3k7yA:
undetectable
4kykB-3k7yA:
undetectable		 4kykA-3k7yA:
17.15
4kykB-3k7yA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)		 3k7y ASPARTATE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		5 / 9 GLY A 106
SER A 246
SER A 248
GLY A 105
THR A 107
 PLP  A 406 (-3.4A)
PLP  A 406 (-2.8A)
PLP  A 406 (-2.6A)
PLP  A 406 (-3.6A)
PLP  A 406 (-3.8A)
 1.48A 4lb0A-3k7yA:
undetectable		 4lb0A-3k7yA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3k7y ASPARTATE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		4 / 6 ASN A 160
GLU A 192
TYR A 195
LEU A 165
 None
 1.26A 4twdB-3k7yA:
undetectable
4twdC-3k7yA:
undetectable		 4twdB-3k7yA:
20.71
4twdC-3k7yA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3k7y ASPARTATE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		4 / 6 ASN A 160
GLU A 192
TYR A 195
LEU A 165
 None
 1.28A 4twdD-3k7yA:
undetectable
4twdE-3k7yA:
undetectable		 4twdD-3k7yA:
20.71
4twdE-3k7yA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 3k7y ASPARTATE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		4 / 7 TYR A 348
PHE A 328
ALA A 395
LEU A 361
 None
 1.03A 4uymA-3k7yA:
undetectable		 4uymA-3k7yA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 3k7y ASPARTATE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		5 / 10 LEU A  69
GLY A  73
ASP A  76
SER A  78
ILE A 291
 None
 1.00A 4xj7C-3k7yA:
undetectable
4xj7D-3k7yA:
undetectable		 4xj7C-3k7yA:
19.10
4xj7D-3k7yA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3k7y ASPARTATE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		4 / 7 LYS A 338
TYR A 343
LEU A 332
PHE A 329
 None
 1.11A 4yv5A-3k7yA:
undetectable		 4yv5A-3k7yA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3k7y ASPARTATE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		4 / 7 LYS A 338
TYR A 343
LEU A 332
PHE A 329
 None
 1.18A 4yv5B-3k7yA:
undetectable		 4yv5B-3k7yA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3k7y ASPARTATE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		4 / 5 TYR A 216
GLY A  37
TYR A 254
GLY A 255
 PLP  A 406 (-4.5A)
None
None
None
 1.04A 5ayfA-3k7yA:
undetectable		 5ayfA-3k7yA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_NPSA602_1
(SERUM ALBUMIN)		 3k7y ASPARTATE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 LEU A 368
PHE A 328
LEU A 332
LEU A 361
SER A 401
 None
 1.23A 5dbyA-3k7yA:
undetectable		 5dbyA-3k7yA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3k7y ASPARTATE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		4 / 7 ILE A  98
CYH A  99
LEU A 261
ALA A 260
 None
 0.95A 5hrqE-3k7yA:
undetectable
5hrqF-3k7yA:
undetectable
5hrqJ-3k7yA:
undetectable		 5hrqE-3k7yA:
4.26
5hrqF-3k7yA:
7.47
5hrqJ-3k7yA:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3k7y ASPARTATE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		4 / 7 HIS A 262
ILE A 263
VAL A 264
GLN A  82
 None
 1.13A 5kkzC-3k7yA:
undetectable
5kkzE-3k7yA:
undetectable		 5kkzC-3k7yA:
13.76
5kkzE-3k7yA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3k7y ASPARTATE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		4 / 7 HIS A 262
ILE A 263
VAL A 264
GLN A  82
 None
 1.17A 5kkzK-3k7yA:
undetectable
5kkzQ-3k7yA:
undetectable		 5kkzK-3k7yA:
21.85
5kkzQ-3k7yA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3k7y ASPARTATE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		4 / 7 HIS A 262
ILE A 263
VAL A 264
GLN A  82
 None
 1.08A 5kkzM-3k7yA:
undetectable
5kkzO-3k7yA:
undetectable		 5kkzM-3k7yA:
13.76
5kkzO-3k7yA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H3D_A_DHIA601_0
(DUF2338
DOMAIN-CONTAINING
PROTEIN)		 3k7y ASPARTATE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		4 / 5 TYR A 161
ASN A 190
TYR A 184
PHE A 151
 None
 1.10A 6h3dA-3k7yA:
2.2		 6h3dA-3k7yA:
22.53