SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k88'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 3k88 CHLOROPHENOL-4-MONOO
XYGENASE COMPONENT 1
(Burkholderia
cepacia) 		5 / 10 GLY A1121
ALA A1122
ILE A1076
GLY A1080
VAL A1152
 None
 0.96A 1t3rA-3k88A:
undetectable		 1t3rA-3k88A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 3k88 CHLOROPHENOL-4-MONOO
XYGENASE COMPONENT 1
(Burkholderia
cepacia) 		5 / 12 GLY A1121
ALA A1122
VAL A1036
ILE A1076
GLY A1080
 None
 0.88A 2r5pB-3k88A:
undetectable		 2r5pB-3k88A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 3k88 CHLOROPHENOL-4-MONOO
XYGENASE COMPONENT 1
(Burkholderia
cepacia) 		5 / 12 GLY A1121
ALA A1122
ILE A1076
GLY A1080
VAL A1152
 None
 1.06A 3cyxA-3k88A:
undetectable		 3cyxA-3k88A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 3k88 CHLOROPHENOL-4-MONOO
XYGENASE COMPONENT 1
(Burkholderia
cepacia) 		5 / 9 ASP A1133
ALA A1122
VAL A1036
ILE A1076
GLY A1080
 None
 1.26A 3el4B-3k88A:
undetectable		 3el4B-3k88A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3k88 CHLOROPHENOL-4-MONOO
XYGENASE COMPONENT 1
(Burkholderia
cepacia) 		4 / 5 ILE A1066
THR A1038
PHE A1110
PHE A1098
 FAD  A1500 (-4.3A)
None
None
None
 1.29A 3em0A-3k88A:
undetectable		 3em0A-3k88A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 3k88 CHLOROPHENOL-4-MONOO
XYGENASE COMPONENT 1
(Burkholderia
cepacia) 		5 / 10 GLY A1121
ALA A1122
ILE A1076
GLY A1080
VAL A1152
 None
 0.97A 3lzvA-3k88A:
undetectable		 3lzvA-3k88A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_2
(PROTEASE)		 3k88 CHLOROPHENOL-4-MONOO
XYGENASE COMPONENT 1
(Burkholderia
cepacia) 		5 / 12 GLY A1121
ALA A1122
ILE A1076
GLY A1080
VAL A1152
 None
 1.00A 3tkgB-3k88A:
undetectable		 3tkgB-3k88A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)		 3k88 CHLOROPHENOL-4-MONOO
XYGENASE COMPONENT 1
(Burkholderia
cepacia) 		5 / 12 GLY A1121
ALA A1122
ILE A1076
GLY A1080
VAL A1152
 None
 1.01A 3tkgC-3k88A:
undetectable		 3tkgC-3k88A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 3k88 CHLOROPHENOL-4-MONOO
XYGENASE COMPONENT 1
(Burkholderia
cepacia) 		5 / 9 ALA A1129
GLY A1090
ALA A1089
THR A1173
VAL A1033
 None
 1.15A 4r1zA-3k88A:
undetectable		 4r1zA-3k88A:
18.22