SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k8c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 3k8c RIBOSE 5-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		4 / 7 ASP A  45
GLY A  74
ILE A  77
ALA A  54
 None
RES  A 160 (-3.4A)
None
None
 0.72A 1n49A-3k8cA:
undetectable		 1n49A-3k8cA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 3k8c RIBOSE 5-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		3 / 3 ASP A  10
GLY A  70
TYR A  46
 RES  A 160 (-3.1A)
RES  A 160 (-3.3A)
RES  A 160 ( 4.3A)
 0.73A 3w9tC-3k8cA:
undetectable		 3w9tC-3k8cA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 3k8c RIBOSE 5-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		3 / 3 ASP A  10
GLY A  70
TYR A  46
 RES  A 160 (-3.1A)
RES  A 160 (-3.3A)
RES  A 160 ( 4.3A)
 0.73A 3w9tG-3k8cA:
undetectable		 3w9tG-3k8cA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB304_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 3k8c RIBOSE 5-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		4 / 4 GLY A  70
SER A  71
ARG A 113
PRO A  12
 RES  A 160 (-3.3A)
RES  A 160 (-3.2A)
RES  A 160 (-3.1A)
RES  A 160 ( 4.7A)
 1.09A 4m93B-3k8cA:
undetectable
4m93C-3k8cA:
0.0		 4m93B-3k8cA:
20.54
4m93C-3k8cA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3k8c RIBOSE 5-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		3 / 3 ARG A 140
HIS A 138
ARG A 141
 None
 0.94A 5iaoC-3k8cA:
undetectable		 5iaoC-3k8cA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3k8c RIBOSE 5-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		3 / 3 ARG A 140
HIS A 138
ARG A 141
 None
 0.98A 5iaoF-3k8cA:
undetectable		 5iaoF-3k8cA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 3k8c RIBOSE 5-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		4 / 5 THR A   9
THR A 114
HIS A  91
LEU A  89
 None
 1.27A 5utuH-3k8cA:
3.4		 5utuH-3k8cA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 3k8c RIBOSE 5-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		4 / 5 THR A   9
THR A 115
HIS A  91
LEU A  89
 None
 1.24A 5utuH-3k8cA:
3.4		 5utuH-3k8cA:
16.94