SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k8i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3k8i 30KLP
(Treponema
pallidum) 		5 / 12 GLU A  92
ARG A 161
GLY A  41
GLY A  43
ALA A  85
 None
 1.31A 1httC-3k8iA:
undetectable		 1httC-3k8iA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 3k8i 30KLP
(Treponema
pallidum) 		5 / 12 ILE A  62
ARG A  61
TYR A 225
LEU A  58
LEU A 216
 None
 1.26A 2rctA-3k8iA:
undetectable		 2rctA-3k8iA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 3k8i 30KLP
(Treponema
pallidum) 		3 / 3 ASN A 223
ALA A 270
ARG A  61
 None
 0.84A 3tj7C-3k8iA:
undetectable
3tj7D-3k8iA:
undetectable		 3tj7C-3k8iA:
20.22
3tj7D-3k8iA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 3k8i 30KLP
(Treponema
pallidum) 		4 / 5 VAL A 187
LEU A  48
LEU A 189
ILE A 277
 None
 0.88A 4a9jA-3k8iA:
undetectable		 4a9jA-3k8iA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 3k8i 30KLP
(Treponema
pallidum) 		4 / 5 VAL A 187
LEU A  48
LEU A 189
ILE A 277
 None
 0.86A 4a9jB-3k8iA:
undetectable		 4a9jB-3k8iA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 3k8i 30KLP
(Treponema
pallidum) 		3 / 3 TYR A 217
THR A 219
THR A 228
 None
 0.49A 5aoxB-3k8iA:
undetectable		 5aoxB-3k8iA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 3k8i 30KLP
(Treponema
pallidum) 		3 / 3 TYR A 217
THR A 219
THR A 228
 None
 0.57A 5aoxE-3k8iA:
undetectable		 5aoxE-3k8iA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3k8i 30KLP
(Treponema
pallidum) 		4 / 8 VAL A 187
LEU A  48
LEU A 189
ILE A 277
 None
 0.78A 5y1yA-3k8iA:
undetectable		 5y1yA-3k8iA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3k8i 30KLP
(Treponema
pallidum) 		4 / 6 PHE A 197
VAL A 276
LEU A 202
LEU A 201
 None
 1.01A 6e43D-3k8iA:
undetectable		 6e43D-3k8iA:
22.14