SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k8v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 3k8v FLAGELLIN HOMOLOG
(Sphingomonas
sp.
A1) 		5 / 12 ARG A  93
ALA A 303
ALA A 127
ILE A  92
ILE A 123
 None
 0.95A 1fk6A-3k8vA:
undetectable		 1fk6A-3k8vA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 3k8v FLAGELLIN HOMOLOG
(Sphingomonas
sp.
A1) 		4 / 7 GLY A  47
ASP A 346
SER A  51
ALA A 345
 None
 0.85A 1gxsA-3k8vA:
undetectable
1gxsB-3k8vA:
undetectable		 1gxsA-3k8vA:
21.15
1gxsB-3k8vA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 3k8v FLAGELLIN HOMOLOG
(Sphingomonas
sp.
A1) 		5 / 12 PHE A 142
LEU A  82
GLY A 315
GLY A  71
LEU A  74
 None
 0.97A 1igxA-3k8vA:
undetectable		 1igxA-3k8vA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3k8v FLAGELLIN HOMOLOG
(Sphingomonas
sp.
A1) 		4 / 5 ASP A 301
LEU A 285
ALA A 303
LEU A 304
 None
 1.14A 1nh8A-3k8vA:
undetectable		 1nh8A-3k8vA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3k8v FLAGELLIN HOMOLOG
(Sphingomonas
sp.
A1) 		4 / 8 SER A  86
ARG A 311
ASN A 308
ASN A  87
 None
 1.30A 1rs7B-3k8vA:
undetectable		 1rs7B-3k8vA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3k8v FLAGELLIN HOMOLOG
(Sphingomonas
sp.
A1) 		4 / 8 SER A  86
ARG A 311
ASN A 308
ASN A  87
 None
 1.30A 1zzqB-3k8vA:
undetectable		 1zzqB-3k8vA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3k8v FLAGELLIN HOMOLOG
(Sphingomonas
sp.
A1) 		4 / 6 THR A 232
THR A 291
ASN A 104
ASP A 108
 None
 1.21A 2okcA-3k8vA:
undetectable		 2okcA-3k8vA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 3k8v FLAGELLIN HOMOLOG
(Sphingomonas
sp.
A1) 		4 / 5 VAL A 234
THR A 232
VAL A 203
GLY A 202
 None
 1.10A 2p2fA-3k8vA:
undetectable		 2p2fA-3k8vA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 3k8v FLAGELLIN HOMOLOG
(Sphingomonas
sp.
A1) 		4 / 4 VAL A 234
THR A 232
VAL A 203
GLY A 202
 None
 1.10A 2p2fB-3k8vA:
undetectable		 2p2fB-3k8vA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 3k8v FLAGELLIN HOMOLOG
(Sphingomonas
sp.
A1) 		4 / 8 ILE A 225
LEU A 247
ARG A 217
GLY A 266
 None
 0.87A 2vdbA-3k8vA:
undetectable		 2vdbA-3k8vA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3k8v FLAGELLIN HOMOLOG
(Sphingomonas
sp.
A1) 		5 / 12 SER A 237
ASN A 226
THR A 286
VAL A 287
LEU A 112
 None
 1.35A 2xrlA-3k8vA:
undetectable		 2xrlA-3k8vA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3k8v FLAGELLIN HOMOLOG
(Sphingomonas
sp.
A1) 		5 / 9 ALA A 265
ILE A 181
THR A 273
SER A 179
ILE A 200
 None
 1.32A 3hbbB-3k8vA:
undetectable		 3hbbB-3k8vA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3k8v FLAGELLIN HOMOLOG
(Sphingomonas
sp.
A1) 		4 / 4 LEU A  82
LEU A 304
GLN A 166
GLU A 122
 None
 0.89A 4i41A-3k8vA:
undetectable		 4i41A-3k8vA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 3k8v FLAGELLIN HOMOLOG
(Sphingomonas
sp.
A1) 		5 / 12 LEU A 174
GLY A 281
THR A 296
ILE A  92
VAL A 116
 None
 1.15A 4ok1A-3k8vA:
undetectable		 4ok1A-3k8vA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3k8v FLAGELLIN HOMOLOG
(Sphingomonas
sp.
A1) 		5 / 9 ALA A  78
THR A  77
ALA A  75
ILE A 307
GLY A  83
 None
 1.19A 4qvqK-3k8vA:
undetectable
4qvqL-3k8vA:
undetectable		 4qvqK-3k8vA:
22.77
4qvqL-3k8vA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3k8v FLAGELLIN HOMOLOG
(Sphingomonas
sp.
A1) 		5 / 9 ALA A  78
THR A  77
ALA A  75
ILE A 307
GLY A  83
 None
 1.19A 4qvqY-3k8vA:
undetectable
4qvqZ-3k8vA:
undetectable		 4qvqY-3k8vA:
22.77
4qvqZ-3k8vA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 3k8v FLAGELLIN HOMOLOG
(Sphingomonas
sp.
A1) 		5 / 10 VAL A 255
THR A 273
ILE A 253
GLY A 266
ALA A 268
 None
 1.13A 5mxbA-3k8vA:
undetectable		 5mxbA-3k8vA:
11.40