SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k8z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 6 GLY A 202
VAL A 356
ALA A 198
SER A 197
 None
 0.95A 1p6kA-3k8zA:
0.8		 1p6kA-3k8zA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 ALA A 323
ALA A 301
LYS A 237
SER A 250
ILE A 249
 None
 1.02A 1rg7A-3k8zA:
undetectable		 1rg7A-3k8zA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_A_CHDA1_0
(LIVER
CARBOXYLESTERASE 1)		 3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 5 TRP A 361
GLY A 190
LYS A 185
PRO A 147
 None
 1.48A 2dqyA-3k8zA:
1.0		 2dqyA-3k8zA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_B_CHDB2_0
(LIVER
CARBOXYLESTERASE 1)		 3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		3 / 3 TRP A 361
LYS A 185
PRO A 147
 None
 1.44A 2dqyB-3k8zA:
4.5		 2dqyB-3k8zA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 8 MET A  46
LEU A  41
ARG A 420
SER A  97
 None
 1.19A 2qd2A-3k8zA:
1.9		 2qd2A-3k8zA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_B_CHDB1_0
(FERROCHELATASE)		 3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 10 MET A  46
LEU A  41
ARG A 420
SER A  97
GLY A  76
 None
 1.34A 2qd2B-3k8zA:
1.2		 2qd2B-3k8zA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 8 ILE A 118
GLY A 136
MET A 166
ILE A 141
 None
 0.97A 2qwxA-3k8zA:
2.6
2qwxB-3k8zA:
3.1		 2qwxA-3k8zA:
19.91
2qwxB-3k8zA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 4 THR A  21
VAL A 410
GLY A 113
THR A  78
 None
 1.06A 3cflA-3k8zA:
undetectable		 3cflA-3k8zA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 7 MET A  46
LEU A  41
ARG A 420
SER A  97
GLY A  76
 None
 1.46A 3hcnA-3k8zA:
3.1		 3hcnA-3k8zA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 9 MET A  46
LEU A  41
ARG A 420
SER A  97
GLY A  76
 None
 1.42A 3hcnB-3k8zA:
2.0		 3hcnB-3k8zA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 9 MET A  46
LEU A  41
ARG A 420
SER A  97
GLY A  76
 None
 1.27A 3hcoA-3k8zA:
3.1		 3hcoA-3k8zA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 10 MET A  46
LEU A  41
ARG A 420
SER A  97
GLY A  76
 None
 1.27A 3hcoB-3k8zA:
2.4		 3hcoB-3k8zA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 10 MET A  46
LEU A  41
ARG A 420
SER A  97
GLY A  76
 None
 1.40A 3hcpB-3k8zA:
2.1		 3hcpB-3k8zA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 VAL A  24
VAL A 347
LEU A 348
VAL A 408
GLY A 105
 None
 1.19A 3pghA-3k8zA:
undetectable		 3pghA-3k8zA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 5 ILE A  82
SER A  97
LYS A 115
GLY A 116
 None
 1.01A 3tkdB-3k8zA:
undetectable		 3tkdB-3k8zA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 5 ILE A  82
SER A  97
LYS A 115
GLY A 116
 None
 1.04A 3tkdA-3k8zA:
undetectable		 3tkdA-3k8zA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 GLY A 243
ALA A 244
ILE A 297
VAL A 225
VAL A 223
 None
 1.05A 3ucbA-3k8zA:
undetectable		 3ucbA-3k8zA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 5 MET A  46
LEU A  41
ARG A 420
SER A  97
 None
 1.10A 4kmmB-3k8zA:
2.1		 4kmmB-3k8zA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 6 ARG A  47
GLY A 180
PRO A  77
THR A  78
 None
 1.00A 4l1aB-3k8zA:
undetectable		 4l1aB-3k8zA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		3 / 3 TYR A 170
GLY A 146
PRO A 147
 None
 0.68A 4qwpA-3k8zA:
undetectable		 4qwpA-3k8zA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		3 / 3 GLU A 415
ALA A 416
PHE A 419
 None
 0.45A 4v1fA-3k8zA:
undetectable		 4v1fA-3k8zA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		3 / 3 GLU A 415
ALA A 416
PHE A 419
 None
 0.52A 4v1fC-3k8zA:
undetectable		 4v1fC-3k8zA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		3 / 3 MET A 125
GLU A 129
LEU A 133
 None
 0.38A 4v2oB-3k8zA:
undetectable		 4v2oB-3k8zA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 8 ILE A 319
VAL A 321
GLU A 209
CYH A 206
 None
 1.16A 5dqyA-3k8zA:
undetectable		 5dqyA-3k8zA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 9 SER A  97
GLY A  67
GLU A  90
ILE A 141
ALA A 140
 None
 1.36A 5entC-3k8zA:
undetectable		 5entC-3k8zA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 GLY A 113
ILE A 141
PHE A 181
GLY A  81
GLY A  80
 None
 0.92A 5koxA-3k8zA:
undetectable		 5koxA-3k8zA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 GLY A 136
VAL A 138
PHE A 181
PRO A 152
GLY A  81
 None
 1.20A 6brdC-3k8zA:
undetectable		 6brdC-3k8zA:
11.03