SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k92'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 THR A 200
VAL A 204
GLY A 230
ALA A 302
ILE A 226
 None
 0.92A 1bx4A-3k92A:
undetectable		 1bx4A-3k92A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 4 ILE A 250
MET A 240
VAL A 322
GLY A 249
 None
 1.15A 1e06B-3k92A:
undetectable		 1e06B-3k92A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		6 / 12 GLY A 244
ALA A 245
ILE A 298
VAL A 212
ILE A 226
ILE A 224
 None
 1.02A 1hshA-3k92A:
undetectable		 1hshA-3k92A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 9 ALA A 245
ILE A 298
VAL A 212
ILE A 226
ILE A 224
 None
 0.90A 1hshB-3k92A:
undetectable		 1hshB-3k92A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_1
(HIV-II PROTEASE)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 GLY A 244
ALA A 245
ILE A 298
ILE A 226
ILE A 224
 None
 0.87A 1hshC-3k92A:
undetectable		 1hshC-3k92A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		3 / 3 ARG A  69
THR A 159
VAL A  83
 None
 0.89A 1hxbA-3k92A:
undetectable		 1hxbA-3k92A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 6 LEU A 344
ASP A 401
ILE A  24
GLU A 323
 None
 0.87A 1mt1A-3k92A:
undetectable
1mt1F-3k92A:
undetectable		 1mt1A-3k92A:
8.70
1mt1F-3k92A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 6 LEU A 344
ASP A 401
ILE A 331
GLU A 323
 None
 1.04A 1mt1A-3k92A:
undetectable
1mt1F-3k92A:
undetectable		 1mt1A-3k92A:
8.70
1mt1F-3k92A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 7 ILE A  24
GLU A 323
LEU A 344
ASP A 401
 None
 0.91A 1mt1H-3k92A:
undetectable
1mt1K-3k92A:
undetectable		 1mt1H-3k92A:
14.77
1mt1K-3k92A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 8 LEU A 344
ASP A 401
ILE A  24
GLU A 323
 None
 0.82A 1n13A-3k92A:
undetectable
1n13F-3k92A:
undetectable		 1n13A-3k92A:
8.70
1n13F-3k92A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 7 LEU A 344
ASP A 401
ILE A  24
GLU A 323
 None
 0.82A 1n13I-3k92A:
undetectable
1n13L-3k92A:
undetectable		 1n13I-3k92A:
8.70
1n13L-3k92A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 ILE A  99
GLY A 115
GLU A  92
PHE A  18
ASN A  73
 None
 1.22A 1sg9A-3k92A:
2.7		 1sg9A-3k92A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_B_CHDB2_0
(LIVER
CARBOXYLESTERASE 1)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		3 / 3 TRP A 362
LYS A 186
PRO A 148
 None
 1.42A 2dqyB-3k92A:
4.7		 2dqyB-3k92A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		3 / 3 LYS A 104
GLY A 327
PRO A 328
 None
 0.94A 2hreB-3k92A:
3.9		 2hreB-3k92A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 ILE A 206
GLY A 106
ASN A 109
VAL A 357
TYR A 359
 None
 1.35A 2nyrB-3k92A:
2.8		 2nyrB-3k92A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 6 ASP A 151
PRO A 153
THR A 184
TRP A 362
 None
 1.33A 2q6oB-3k92A:
1.7		 2q6oB-3k92A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		3 / 3 ARG A  69
THR A 159
VAL A  83
 None
 0.95A 2qakA-3k92A:
undetectable		 2qakA-3k92A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 7 LEU A 344
ASP A 401
ILE A  24
GLU A 323
 None
 0.94A 2qqdA-3k92A:
undetectable
2qqdE-3k92A:
undetectable		 2qqdA-3k92A:
8.94
2qqdE-3k92A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 8 ILE A  24
GLU A 323
LEU A 344
ASP A 401
 None
 0.82A 2qqdB-3k92A:
undetectable
2qqdC-3k92A:
undetectable		 2qqdB-3k92A:
14.77
2qqdC-3k92A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 8 ILE A 248
GLY A 249
LEU A 291
LEU A 292
 None
 0.81A 2vctC-3k92A:
undetectable		 2vctC-3k92A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		3 / 3 TRP A 362
VAL A 383
ARG A 381
 None
 0.96A 3b0wA-3k92A:
undetectable		 3b0wA-3k92A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 8 SER A  70
ALA A  96
ILE A  25
THR A  21
 None
 0.83A 3bpxA-3k92A:
undetectable
3bpxB-3k92A:
undetectable		 3bpxA-3k92A:
18.26
3bpxB-3k92A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 THR A 159
ILE A 119
GLY A 118
ASN A 160
LEU A 131
 None
None
None
PEG  A 425 (-3.3A)
PEG  A 425 (-4.5A)
 1.17A 3eeyF-3k92A:
3.4		 3eeyF-3k92A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 11 GLY A 228
ALA A 303
ILE A 226
ALA A 237
ASP A 252
 None
 1.23A 3nmuB-3k92A:
undetectable
3nmuJ-3k92A:
3.8		 3nmuB-3k92A:
22.12
3nmuJ-3k92A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_B_DXCB92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 5 VAL A 300
VAL A 322
ARG A 324
LYS A 213
 None
 1.32A 3rv5A-3k92A:
undetectable
3rv5B-3k92A:
0.4		 3rv5A-3k92A:
11.48
3rv5B-3k92A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		3 / 3 GLY A 113
THR A 102
ASN A  73
 None
 0.51A 3v4tD-3k92A:
undetectable		 3v4tD-3k92A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 LEU A 103
GLY A 410
LEU A  32
HIS A 398
THR A 394
 None
 1.29A 4olmA-3k92A:
undetectable		 4olmA-3k92A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		3 / 3 TYR A 171
GLY A 147
PRO A 148
 None
 0.66A 4qwpA-3k92A:
undetectable		 4qwpA-3k92A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		3 / 3 MET A 126
GLU A 130
LEU A 134
 None
 0.36A 4v2oB-3k92A:
undetectable		 4v2oB-3k92A:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 GLY A 244
ALA A 245
ILE A 298
ILE A 226
ILE A 224
 None
 0.87A 5e5jB-3k92A:
undetectable		 5e5jB-3k92A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 GLY A 244
ALA A 245
ILE A 298
ILE A 226
ILE A 224
 None
 0.83A 5e5kB-3k92A:
undetectable		 5e5kB-3k92A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 9 SER A  98
GLY A  67
GLU A  91
ILE A 142
ALA A 141
 None
 1.35A 5entC-3k92A:
undetectable		 5entC-3k92A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		3 / 3 LYS A  56
ASP A  58
ILE A  53
 None
 0.77A 5kc4E-3k92A:
1.4		 5kc4E-3k92A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 GLY A 114
ILE A 142
PHE A 182
GLY A  82
GLY A  81
 None
 0.95A 5koxA-3k92A:
undetectable		 5koxA-3k92A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 5 VAL A 424
PRO A  35
GLY A  36
TYR A  34
 None
 1.14A 5x80A-3k92A:
undetectable
5x80B-3k92A:
undetectable		 5x80A-3k92A:
16.21
5x80B-3k92A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 5 PRO A  35
GLY A  36
TYR A  34
VAL A 424
 None
 1.18A 5x80C-3k92A:
undetectable
5x80D-3k92A:
undetectable		 5x80C-3k92A:
16.21
5x80D-3k92A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 VAL A 383
SER A 386
LEU A 110
VAL A 355
GLY A 353
 None
 1.16A 6a94B-3k92A:
undetectable		 6a94B-3k92A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 GLY A 137
VAL A 139
PHE A 182
PRO A 153
GLY A  82
 None
 1.19A 6brdC-3k92A:
undetectable		 6brdC-3k92A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 LEU A 292
GLY A 228
VAL A 300
LEU A 299
ILE A 298
 None
 0.90A 6ecxA-3k92A:
undetectable		 6ecxA-3k92A:
23.38