SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k9d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		4 / 7 TYR A 208
GLY A 216
ILE A 434
GLY A 423
 None
 0.82A 11gsB-3k9dA:
undetectable		 11gsB-3k9dA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 122
THR A 124
PRO A 121
 CL  A 465 (-4.1A)
None
CL  A 465 (-4.1A)
 0.84A 1a7yA-3k9dA:
undetectable		 1a7yA-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 124
PRO A 121
THR A 122
 None
CL  A 465 (-4.1A)
CL  A 465 (-4.1A)
 0.77A 1a7yB-3k9dA:
undetectable		 1a7yB-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		6 / 12 THR A 412
GLY A 409
ALA A 404
GLY A 403
ALA A 252
ILE A 250
 None
 1.31A 1bx4A-3k9dA:
undetectable		 1bx4A-3k9dA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 11 ILE A 172
ILE A  36
LEU A 439
PRO A 436
ILE A 139
 None
 1.18A 1dg5A-3k9dA:
undetectable		 1dg5A-3k9dA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 124
PRO A 121
THR A 122
 None
CL  A 465 (-4.1A)
CL  A 465 (-4.1A)
 0.85A 1dscC-3k9dA:
undetectable		 1dscC-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 122
THR A 124
PRO A 121
 CL  A 465 (-4.1A)
None
CL  A 465 (-4.1A)
 0.64A 1dscC-3k9dA:
undetectable		 1dscC-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 122
THR A 124
PRO A 121
 CL  A 465 (-4.1A)
None
CL  A 465 (-4.1A)
 0.78A 1fjaC-3k9dA:
undetectable		 1fjaC-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 122
THR A 124
PRO A 121
 CL  A 465 (-4.1A)
None
CL  A 465 (-4.1A)
 0.78A 1fjaD-3k9dA:
undetectable		 1fjaD-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 10 GLY A  47
ALA A 161
THR A 129
SER A 159
ALA A 162
 None
 1.30A 1gtnO-3k9dA:
undetectable
1gtnP-3k9dA:
undetectable		 1gtnO-3k9dA:
9.13
1gtnP-3k9dA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 9 GLY A  47
ALA A 161
THR A 129
SER A 159
ALA A 162
 None
 1.31A 1gtnQ-3k9dA:
undetectable
1gtnR-3k9dA:
undetectable		 1gtnQ-3k9dA:
9.13
1gtnR-3k9dA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 122
THR A 124
PRO A 121
 CL  A 465 (-4.1A)
None
CL  A 465 (-4.1A)
 0.79A 1i3wE-3k9dA:
undetectable		 1i3wE-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 122
THR A 124
PRO A 121
 CL  A 465 (-4.1A)
None
CL  A 465 (-4.1A)
 0.82A 1i3wF-3k9dA:
undetectable		 1i3wF-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 124
PRO A 121
THR A 122
 None
CL  A 465 (-4.1A)
CL  A 465 (-4.1A)
 0.85A 1i3wG-3k9dA:
undetectable		 1i3wG-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 122
THR A 124
PRO A 121
 CL  A 465 (-4.1A)
None
CL  A 465 (-4.1A)
 0.76A 1i3wG-3k9dA:
undetectable		 1i3wG-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 122
THR A 124
PRO A 121
 CL  A 465 (-4.1A)
None
CL  A 465 (-4.1A)
 0.78A 1i3wH-3k9dA:
undetectable		 1i3wH-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 124
PRO A 121
THR A 122
 None
CL  A 465 (-4.1A)
CL  A 465 (-4.1A)
 0.79A 1mnvD-3k9dA:
undetectable		 1mnvD-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 122
THR A 124
PRO A 121
 CL  A 465 (-4.1A)
None
CL  A 465 (-4.1A)
 0.74A 1mnvD-3k9dA:
undetectable		 1mnvD-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		4 / 5 ILE A 195
VAL A 217
ALA A 252
CYH A 251
 None
 0.86A 1mz9C-3k9dA:
undetectable		 1mz9C-3k9dA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 122
THR A 124
PRO A 121
 CL  A 465 (-4.1A)
None
CL  A 465 (-4.1A)
 0.82A 1qfiA-3k9dA:
undetectable		 1qfiA-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		4 / 8 ALA A 207
TYR A 208
GLY A 199
GLY A 218
 None
 0.83A 1rukH-3k9dA:
undetectable
1rukL-3k9dA:
undetectable		 1rukH-3k9dA:
20.39
1rukL-3k9dA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 124
PRO A 121
THR A 122
 None
CL  A 465 (-4.1A)
CL  A 465 (-4.1A)
 0.82A 1unjF-3k9dA:
undetectable		 1unjF-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 124
PRO A 121
THR A 122
 None
CL  A 465 (-4.1A)
CL  A 465 (-4.1A)
 0.79A 1unjL-3k9dA:
undetectable		 1unjL-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 122
THR A 124
PRO A 121
 CL  A 465 (-4.1A)
None
CL  A 465 (-4.1A)
 0.75A 1unjL-3k9dA:
undetectable		 1unjL-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 124
PRO A 121
THR A 122
 None
CL  A 465 (-4.1A)
CL  A 465 (-4.1A)
 0.75A 1unjR-3k9dA:
undetectable		 1unjR-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 122
THR A 124
PRO A 121
 CL  A 465 (-4.1A)
None
CL  A 465 (-4.1A)
 0.76A 1unjR-3k9dA:
undetectable		 1unjR-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 122
THR A 124
PRO A 121
 CL  A 465 (-4.1A)
None
CL  A 465 (-4.1A)
 0.74A 1unjW-3k9dA:
undetectable		 1unjW-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 124
PRO A 121
THR A 122
 None
CL  A 465 (-4.1A)
CL  A 465 (-4.1A)
 0.75A 1unjX-3k9dA:
undetectable		 1unjX-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 122
THR A 124
PRO A 121
 CL  A 465 (-4.1A)
None
CL  A 465 (-4.1A)
 0.77A 1unjX-3k9dA:
undetectable		 1unjX-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 124
PRO A 121
THR A 122
 None
CL  A 465 (-4.1A)
CL  A 465 (-4.1A)
 0.76A 1unmE-3k9dA:
undetectable		 1unmE-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 122
THR A 124
PRO A 121
 CL  A 465 (-4.1A)
None
CL  A 465 (-4.1A)
 0.76A 1unmE-3k9dA:
undetectable		 1unmE-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 124
PRO A 121
THR A 122
 None
CL  A 465 (-4.1A)
CL  A 465 (-4.1A)
 0.79A 1unmF-3k9dA:
undetectable		 1unmF-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 122
THR A 124
PRO A 121
 CL  A 465 (-4.1A)
None
CL  A 465 (-4.1A)
 0.75A 1unmF-3k9dA:
undetectable		 1unmF-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 122
GLU A  61
HIS A 144
 CL  A 465 (-4.1A)
None
None
 0.88A 1xwfA-3k9dA:
4.0		 1xwfA-3k9dA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 122
GLU A  61
HIS A 144
 CL  A 465 (-4.1A)
None
None
 0.85A 1xwfB-3k9dA:
4.3		 1xwfB-3k9dA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 122
GLU A  61
HIS A 144
 CL  A 465 (-4.1A)
None
None
 0.85A 1xwfC-3k9dA:
2.4		 1xwfC-3k9dA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 122
GLU A  61
HIS A 144
 CL  A 465 (-4.1A)
None
None
 0.86A 1xwfD-3k9dA:
4.9		 1xwfD-3k9dA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 12 ILE A 346
ILE A 326
ALA A 327
ILE A 365
PHE A 271
 None
 1.23A 1xzxX-3k9dA:
undetectable		 1xzxX-3k9dA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 122
THR A 124
PRO A 121
 CL  A 465 (-4.1A)
None
CL  A 465 (-4.1A)
 0.88A 209dC-3k9dA:
undetectable		 209dC-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 SER A 362
GLU A 260
ASP A 381
 None
 0.81A 2avdB-3k9dA:
4.9		 2avdB-3k9dA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		4 / 5 ALA A 135
ILE A 133
ASN A 137
ILE A 139
 None
 1.06A 2h4jA-3k9dA:
3.4		 2h4jA-3k9dA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		4 / 4 LEU A 279
ILE A 346
ILE A 310
ALA A 311
 None
 0.80A 2i30A-3k9dA:
undetectable		 2i30A-3k9dA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		4 / 4 LEU A 375
THR A 374
ILE A 226
HIS A 378
 None
 1.15A 2jfaB-3k9dA:
undetectable		 2jfaB-3k9dA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		4 / 7 ILE A  39
PRO A 436
ILE A 131
ILE A  85
 None
 0.88A 2q83A-3k9dA:
undetectable		 2q83A-3k9dA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 12 GLY A 403
GLY A 406
ARG A 396
ALA A 224
PHE A 245
 None
 1.26A 2vdvE-3k9dA:
2.8		 2vdvE-3k9dA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 11 GLY A 403
GLY A 406
ARG A 396
ALA A 224
PHE A 245
 None
 1.26A 2vdvF-3k9dA:
2.7		 2vdvF-3k9dA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 124
PRO A 121
THR A 122
 None
CL  A 465 (-4.1A)
CL  A 465 (-4.1A)
 0.84A 316dC-3k9dA:
undetectable		 316dC-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		4 / 8 VAL A 285
GLY A 288
LYS A 289
PRO A 337
 None
 0.58A 3bjwA-3k9dA:
undetectable		 3bjwA-3k9dA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		4 / 7 VAL A 155
THR A 154
ILE A 151
ILE A 116
 None
 0.76A 3deuA-3k9dA:
undetectable		 3deuA-3k9dA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 10 ALA A 344
ILE A 291
ILE A 326
ALA A 311
ILE A 310
 None
 1.03A 3ekwA-3k9dA:
undetectable		 3ekwA-3k9dA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 12 GLY A 403
ALA A 404
THR A 411
ALA A 224
ILE A 239
 None
 1.18A 3id6C-3k9dA:
4.0		 3id6C-3k9dA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 11 LEU A 414
ASN A 433
ALA A 417
ILE A 250
THR A 412
 None
 1.13A 3spkA-3k9dA:
undetectable		 3spkA-3k9dA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 9 LEU A 414
ASN A 433
ALA A 417
ILE A 250
THR A 412
 None
 1.13A 3spkA-3k9dA:
undetectable		 3spkA-3k9dA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 12 ILE A 133
TYR A 127
ILE A 158
THR A 419
ILE A 172
 None
 1.27A 3vrjA-3k9dA:
undetectable
3vrjC-3k9dA:
undetectable		 3vrjA-3k9dA:
19.23
3vrjC-3k9dA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		4 / 5 GLY A 114
ILE A 139
VAL A 194
SER A 132
 None
 1.23A 4d33A-3k9dA:
undetectable		 4d33A-3k9dA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		4 / 5 GLY A 114
ILE A 139
VAL A 194
SER A 132
 None
 1.19A 4d33B-3k9dA:
undetectable		 4d33B-3k9dA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 THR A 124
PRO A 121
THR A 122
 None
CL  A 465 (-4.1A)
CL  A 465 (-4.1A)
 0.78A 4hivD-3k9dA:
undetectable		 4hivD-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 SER A 142
ALA A 113
VAL A 112
 None
 0.68A 4o2bC-3k9dA:
undetectable		 4o2bC-3k9dA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 12 ASN A 137
LEU A 115
GLY A 114
ILE A 215
THR A 419
 None
 1.25A 4o5fA-3k9dA:
undetectable
4o5fB-3k9dA:
undetectable		 4o5fA-3k9dA:
25.05
4o5fB-3k9dA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 12 THR A 419
ASN A 137
LEU A 115
GLY A 114
ILE A 215
 None
 1.26A 4o5fA-3k9dA:
undetectable
4o5fB-3k9dA:
undetectable		 4o5fA-3k9dA:
25.05
4o5fB-3k9dA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 9 ALA A 207
SER A 132
GLY A 114
ALA A 113
THR A 192
 None
 1.24A 4r1zA-3k9dA:
undetectable		 4r1zA-3k9dA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		4 / 5 ILE A 408
PHE A  64
HIS A  80
ASP A  69
 None
 1.41A 4rzvB-3k9dA:
undetectable		 4rzvB-3k9dA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_B_QELB503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 11 THR A 124
PRO A 117
ALA A 147
PHE A 141
GLU A  60
 None
 1.04A 5ewjA-3k9dA:
3.0
5ewjB-3k9dA:
4.2		 5ewjA-3k9dA:
21.28
5ewjB-3k9dA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 12 THR A 124
PRO A 117
ALA A 147
PHE A 141
GLU A  60
 None
 1.02A 5ewjC-3k9dA:
3.0
5ewjD-3k9dA:
2.4		 5ewjC-3k9dA:
21.28
5ewjD-3k9dA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		4 / 6 GLY A 182
THR A 183
SER A  10
VAL A  14
 None
 1.04A 5ewuA-3k9dA:
2.9		 5ewuA-3k9dA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		4 / 6 GLY A 182
THR A 183
SER A  10
VAL A  14
 None
 1.10A 5ewuB-3k9dA:
undetectable		 5ewuB-3k9dA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		4 / 6 LEU A 405
LEU A 418
PHE A 245
HIS A  80
 None
 0.80A 5gs4A-3k9dA:
undetectable		 5gs4A-3k9dA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		4 / 5 LEU A 405
LEU A 418
PHE A 245
HIS A  80
 None
 0.87A 5gtrA-3k9dA:
undetectable		 5gtrA-3k9dA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 LYS A  41
ASP A  37
ILE A 126
 None
 0.73A 5kc4E-3k9dA:
undetectable		 5kc4E-3k9dA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 12 THR A 401
SER A 242
GLY A 407
ALA A 252
THR A 374
 None
 1.38A 5l5zH-3k9dA:
undetectable
5l5zI-3k9dA:
undetectable		 5l5zH-3k9dA:
21.44
5l5zI-3k9dA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 12 THR A 401
SER A 242
GLY A 407
ALA A 252
THR A 374
 None
 1.37A 5l5zV-3k9dA:
undetectable
5l5zW-3k9dA:
undetectable		 5l5zV-3k9dA:
21.44
5l5zW-3k9dA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 12 ILE A 408
LYS A 237
GLY A 403
HIS A 378
GLY A 407
 None
 1.04A 5l6eA-3k9dA:
undetectable		 5l6eA-3k9dA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 3k9d ALDEHYDE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 SER A 142
ALA A 113
VAL A 112
 None
 0.51A 5xiwC-3k9dA:
undetectable		 5xiwC-3k9dA:
12.47