SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k9m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 3k9m CATHEPSIN B
(Homo
sapiens) 		7 / 10 GLN A  23
GLY A  27
SER A  28
TRP A  30
PHE A  32
HIS A 199
ALA A 200
 None
 0.48A 1stfE-3k9mA:
26.9
1stfI-3k9mA:
undetectable		 1stfE-3k9mA:
32.08
1stfI-3k9mA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3k9m CATHEPSIN B
(Homo
sapiens) 		4 / 6 LEU A 181
VAL A 246
ILE A 201
MET A 195
 None
 1.14A 2hyyB-3k9mA:
undetectable		 2hyyB-3k9mA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3k9m CATHEPSIN B
(Homo
sapiens) 		4 / 6 LEU A 181
VAL A 246
ILE A 201
MET A 195
 None
 1.10A 2hyyC-3k9mA:
undetectable		 2hyyC-3k9mA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3k9m CATHEPSIN B
(Homo
sapiens) 		4 / 5 LEU A 181
VAL A 246
MET A 195
ARG A 235
 None
 1.08A 2oiqA-3k9mA:
undetectable		 2oiqA-3k9mA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)		 3k9m CATHEPSIN B
(Homo
sapiens) 		5 / 9 PHE A 174
GLU A 245
VAL A 247
GLY A  33
GLU A  78
 None
 1.49A 2w98A-3k9mA:
undetectable		 2w98A-3k9mA:
21.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 3k9m CATHEPSIN B
(Homo
sapiens) 		4 / 7 GLN A  23
GLY A  27
HIS A 199
TRP A 221
 None
 0.58A 3ai8A-3k9mA:
39.5		 3ai8A-3k9mA:
99.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3k9m CATHEPSIN B
(Homo
sapiens) 		4 / 7 LEU A 181
VAL A 246
MET A 195
ARG A 235
 None
 1.14A 3ik3A-3k9mA:
undetectable		 3ik3A-3k9mA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3k9m CATHEPSIN B
(Homo
sapiens) 		4 / 7 LEU A 181
VAL A 246
MET A 195
ARG A 235
 None
 1.17A 3ik3B-3k9mA:
undetectable		 3ik3B-3k9mA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3k9m CATHEPSIN B
(Homo
sapiens) 		4 / 6 LEU A 181
VAL A 246
ILE A 201
MET A 195
 None
 1.18A 3k5vA-3k9mA:
undetectable		 3k5vA-3k9mA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3k9m CATHEPSIN B
(Homo
sapiens) 		4 / 6 LEU A 181
VAL A 246
ILE A 201
MET A 195
 None
 1.24A 3k5vB-3k9mA:
undetectable		 3k5vB-3k9mA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 3k9m CATHEPSIN B
(Homo
sapiens) 		5 / 6 TYR A 136
GLY A  99
VAL A  52
HIS A 145
SER A  90
 None
 1.39A 3tj7A-3k9mA:
undetectable
3tj7B-3k9mA:
undetectable		 3tj7A-3k9mA:
20.70
3tj7B-3k9mA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 3k9m CATHEPSIN B
(Homo
sapiens) 		5 / 6 TYR A 136
GLY A  99
VAL A  52
HIS A 145
SER A  90
 None
 1.41A 3tj7C-3k9mA:
undetectable
3tj7D-3k9mA:
undetectable		 3tj7C-3k9mA:
20.70
3tj7D-3k9mA:
20.70