SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k9y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		3 / 3 GLU A 116
TYR A 119
PHE A 450
 None
 0.90A 1eqbB-3k9yA:
undetectable		 1eqbB-3k9yA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		3 / 3 GLU A 116
TYR A 119
PHE A 450
 None
 0.91A 1eqbA-3k9yA:
undetectable		 1eqbA-3k9yA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		3 / 3 GLU A 116
TYR A 119
PHE A 450
 None
 0.90A 1eqbD-3k9yA:
undetectable		 1eqbD-3k9yA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		3 / 3 GLU A 116
TYR A 119
PHE A 450
 None
 0.90A 1eqbC-3k9yA:
undetectable		 1eqbC-3k9yA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		3 / 3 ARG A 512
ARG A 344
ARG A 197
 None
 1.00A 1l7fA-3k9yA:
undetectable		 1l7fA-3k9yA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		3 / 3 ARG A 512
ARG A 344
ARG A 197
 None
 0.97A 1l7hA-3k9yA:
undetectable		 1l7hA-3k9yA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		4 / 6 PRO A 169
MET A 173
ALA A 368
GLU A 369
 None
 1.13A 1qhyA-3k9yA:
undetectable		 1qhyA-3k9yA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		4 / 4 LEU A 476
SER A 384
LEU A 352
LEU A 377
 None
 1.18A 1yajA-3k9yA:
undetectable		 1yajA-3k9yA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		4 / 5 LEU A  86
ILE A  73
LEU A  70
SER A  69
 None
None
CM5  A 517 ( 4.6A)
None
 0.87A 2byoA-3k9yA:
undetectable		 2byoA-3k9yA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		3 / 3 ALA A 326
THR A 330
CYH A 462
 HEM  A 520 ( 3.3A)
HEM  A 520 ( 3.8A)
HEM  A 520 ( 2.2A)
 0.55A 3e4eA-3k9yA:
33.6		 3e4eA-3k9yA:
28.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		3 / 3 ALA A 326
THR A 330
CYH A 462
 HEM  A 520 ( 3.3A)
HEM  A 520 ( 3.8A)
HEM  A 520 ( 2.2A)
 0.47A 3e4eB-3k9yA:
32.5		 3e4eB-3k9yA:
28.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		3 / 3 ARG A 138
VAL A 267
THR A 248
 None
 0.86A 3k4vA-3k9yA:
undetectable		 3k4vA-3k9yA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		3 / 3 ARG A 138
VAL A 267
THR A 248
 None
 0.83A 3nduD-3k9yA:
undetectable		 3nduD-3k9yA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		3 / 3 ARG A 262
LEU A 263
THR A 255
 None
 0.81A 3oxcA-3k9yA:
undetectable		 3oxcA-3k9yA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		4 / 6 ILE A 239
ILE A 131
TRP A 134
MET A 245
 None
 1.30A 3welA-3k9yA:
undetectable		 3welA-3k9yA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		4 / 5 ILE A 179
GLN A 471
ILE A 172
GLU A 171
 None
 1.26A 4a99D-3k9yA:
undetectable		 4a99D-3k9yA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		4 / 6 TYR A 220
ASP A 300
GLU A 171
LEU A 217
 None
 1.42A 4ax8A-3k9yA:
undetectable		 4ax8A-3k9yA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		4 / 6 ARG A  98
HIS A 108
LEU A 415
ASP A 105
 None
 1.45A 4cevA-3k9yA:
undetectable
4cevB-3k9yA:
undetectable		 4cevA-3k9yA:
22.40
4cevB-3k9yA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		4 / 4 PRO A 112
LEU A 115
ILE A 457
ARG A 396
 None
None
None
HEM  A 520 ( 2.8A)
 1.44A 4f4dA-3k9yA:
undetectable		 4f4dA-3k9yA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		4 / 8 TRP A 210
VAL A 182
ILE A 179
LEU A 472
 None
 0.88A 4jq1B-3k9yA:
undetectable		 4jq1B-3k9yA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		4 / 5 ALA A 326
THR A 330
VAL A 391
ILE A 500
 HEM  A 520 ( 3.3A)
HEM  A 520 ( 3.8A)
HEM  A 520 ( 4.8A)
None
 0.82A 4xe3A-3k9yA:
26.6		 4xe3A-3k9yA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		5 / 10 SER A 106
LEU A 115
LEU A 109
ASN A 418
LEU A 422
 None
 1.22A 4yiaA-3k9yA:
undetectable		 4yiaA-3k9yA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		5 / 11 CYH A 462
ALA A 327
ALA A 468
THR A 331
LEU A 371
 HEM  A 520 ( 2.2A)
HEM  A 520 ( 3.4A)
HEM  A 520 ( 4.0A)
HEM  A 520 ( 4.7A)
None
 1.13A 5lf7V-3k9yA:
undetectable
5lf7W-3k9yA:
undetectable		 5lf7V-3k9yA:
17.93
5lf7W-3k9yA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		5 / 12 LEU A  79
GLY A  78
GLY A  77
LEU A 101
MET A  99
 CM5  A 517 ( 4.8A)
None
None
CM5  A 517 ( 4.9A)
None
 1.17A 5uc1A-3k9yA:
undetectable		 5uc1A-3k9yA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		4 / 5 ILE A 338
GLN A 349
THR A 388
LEU A 507
 None
 0.97A 6f3mD-3k9yA:
undetectable		 6f3mD-3k9yA:
20.57