SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ka7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		5 / 12 ILE A 199
LEU A  57
PRO A  58
LEU A  65
ILE A 198
 None
None
FAD  A 500 (-4.1A)
None
None
 0.86A 1df7A-3ka7A:
undetectable		 1df7A-3ka7A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		3 / 3 PHE A  54
LEU A 327
SER A  50
 FAD  A 500 (-4.5A)
None
None
 0.81A 1e7aA-3ka7A:
undetectable		 1e7aA-3ka7A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		5 / 11 LEU A  65
VAL A 416
GLY A 415
LEU A  10
GLU A 410
 None
 1.49A 1jkhA-3ka7A:
undetectable
1jkhB-3ka7A:
undetectable		 1jkhA-3ka7A:
21.32
1jkhB-3ka7A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		4 / 8 LEU A 353
VAL A 310
GLY A 309
LEU A 286
 None
 0.95A 1jlbA-3ka7A:
undetectable		 1jlbA-3ka7A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		5 / 12 SER A  51
PHE A  39
LEU A  57
LEU A  14
LEU A 202
 None
 1.46A 1p33B-3ka7A:
undetectable		 1p33B-3ka7A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		5 / 12 SER A  51
PHE A  39
LEU A  57
LEU A  14
LEU A 202
 None
 1.47A 1p33C-3ka7A:
2.8		 1p33C-3ka7A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		4 / 8 GLY A 309
VAL A 310
SER A 157
ILE A 307
 None
 0.91A 1pk7B-3ka7A:
undetectable		 1pk7B-3ka7A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		5 / 10 GLY A 415
VAL A 412
GLY A 411
ASN A 387
VAL A 397
 None
 1.18A 1pwyE-3ka7A:
undetectable		 1pwyE-3ka7A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		5 / 10 GLY A 415
VAL A 412
GLY A 411
ASN A 387
VAL A 397
 None
 1.22A 1v3qE-3ka7A:
undetectable		 1v3qE-3ka7A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		6 / 12 GLY A  63
ALA A  66
VAL A  76
ILE A 198
VAL A  79
ILE A  78
 None
 1.43A 2avvB-3ka7A:
undetectable		 2avvB-3ka7A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		5 / 8 SER A  51
PHE A  39
LEU A  57
LEU A  14
LEU A 202
 None
 1.48A 2bfpC-3ka7A:
undetectable		 2bfpC-3ka7A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_2
(PROTEASE)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		6 / 12 GLY A  63
ALA A  66
VAL A  76
ILE A 198
VAL A  79
ILE A  78
 None
 1.39A 2o4kB-3ka7A:
undetectable		 2o4kB-3ka7A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		6 / 12 GLY A  63
ALA A  66
VAL A  76
ILE A 198
VAL A  79
ILE A  78
 None
 1.38A 2o4lB-3ka7A:
undetectable		 2o4lB-3ka7A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		4 / 4 SER A  15
GLY A  11
HIS A 214
ASP A 235
 None
FAD  A 500 (-3.3A)
None
None
 1.32A 2oxtC-3ka7A:
3.8		 2oxtC-3ka7A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		6 / 12 GLY A  63
ALA A  66
VAL A  76
ILE A 198
VAL A  79
ILE A  78
 None
 1.39A 2r5pB-3ka7A:
undetectable		 2r5pB-3ka7A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		5 / 9 ILE A  78
ALA A  66
GLU A 203
GLY A  11
LEU A  14
 None
None
None
FAD  A 500 (-3.3A)
None
 1.16A 2v0mB-3ka7A:
undetectable		 2v0mB-3ka7A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		3 / 3 ASP A 240
THR A 215
GLU A  27
 None
 0.81A 2zifB-3ka7A:
undetectable		 2zifB-3ka7A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		5 / 12 PRO A 191
LEU A  57
ASN A  41
VAL A 416
LEU A  14
 None
 1.25A 3a51B-3ka7A:
undetectable		 3a51B-3ka7A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		6 / 12 GLY A  63
ALA A  66
VAL A  76
ILE A 198
VAL A  79
ILE A  78
 None
 1.36A 3bvbA-3ka7A:
undetectable		 3bvbA-3ka7A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		3 / 3 GLU A 169
SER A 279
VAL A 376
 None
None
FAD  A 500 (-3.2A)
 0.75A 3eeoA-3ka7A:
2.8		 3eeoA-3ka7A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		5 / 10 LEU A  10
ILE A 198
PRO A 191
LYS A 196
GLY A 197
 None
 1.12A 3ik6B-3ka7A:
undetectable
3ik6E-3ka7A:
undetectable		 3ik6B-3ka7A:
20.56
3ik6E-3ka7A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		5 / 11 ILE A 198
PRO A 191
LYS A 196
GLY A 197
LEU A  10
 None
 1.15A 3iluB-3ka7A:
undetectable
3iluE-3ka7A:
undetectable		 3iluB-3ka7A:
20.56
3iluE-3ka7A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		5 / 12 PRO A  61
GLY A  60
GLY A 189
VAL A 205
LEU A 202
 None
 0.92A 3m6wA-3ka7A:
undetectable		 3m6wA-3ka7A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB665_1
(ALPHA-GLUCOSIDASE)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		4 / 6 GLU A 149
ASP A 156
ASP A 168
LYS A 166
 None
 1.50A 3pocB-3ka7A:
undetectable		 3pocB-3ka7A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		5 / 12 GLY A 349
GLY A 309
ASP A 352
THR A 304
TYR A  97
 None
 1.07A 3prsA-3ka7A:
undetectable		 3prsA-3ka7A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		4 / 5 ILE A 198
PRO A 191
LYS A 196
GLY A 197
 None
 1.17A 3tkdB-3ka7A:
undetectable		 3tkdB-3ka7A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		4 / 5 ILE A 198
PRO A 191
LYS A 196
GLY A 197
 None
 1.15A 3tkdA-3ka7A:
undetectable		 3tkdA-3ka7A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		3 / 3 GLY A 393
GLU A 388
THR A 389
 None
 0.54A 4kouA-3ka7A:
undetectable		 4kouA-3ka7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		4 / 4 THR A 253
GLY A 398
ASP A 399
SER A 246
 None
FAD  A 500 (-3.2A)
FAD  A 500 (-3.6A)
None
 0.98A 4rfqA-3ka7A:
3.2		 4rfqA-3ka7A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		4 / 6 LEU A  57
ASN A  59
PRO A  58
ARG A  38
 None
None
FAD  A 500 (-4.1A)
FAD  A 500 (-3.7A)
 1.29A 4yv5B-3ka7A:
undetectable		 4yv5B-3ka7A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		4 / 6 LEU A  57
ASN A  59
PRO A  58
ARG A  38
 None
None
FAD  A 500 (-4.1A)
FAD  A 500 (-3.7A)
 1.29A 4yv5A-3ka7A:
undetectable		 4yv5A-3ka7A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		5 / 9 LEU A  13
GLY A  11
LEU A  14
LEU A  69
GLU A 203
 None
FAD  A 500 (-3.3A)
None
None
None
 1.19A 5dqfA-3ka7A:
undetectable		 5dqfA-3ka7A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		3 / 3 ASN A 181
LEU A 163
PHE A 176
 None
 0.77A 5dsgA-3ka7A:
undetectable		 5dsgA-3ka7A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		5 / 11 ALA A 201
ALA A  74
VAL A  72
LEU A  69
LEU A  10
 None
 1.26A 5eb5A-3ka7A:
2.1		 5eb5A-3ka7A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 3ka7 OXIDOREDUCTASE
(Methanosarcina
mazei) 		5 / 12 ASN A 377
GLY A 411
ALA A 413
ILE A 198
LEU A  10
 FAD  A 500 ( 4.7A)
None
None
None
None
 1.12A 6dwnD-3ka7A:
undetectable		 6dwnD-3ka7A:
10.07