SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kao'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 11 GLU A  59
ARG A 301
ARG A 297
LEU A  55
ALA A  80
 None
 1.31A 1cmaA-3kaoA:
undetectable
1cmaB-3kaoA:
undetectable		 1cmaA-3kaoA:
16.31
1cmaB-3kaoA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 10 GLU A  59
ARG A 301
ARG A 297
LEU A  55
ALA A  80
 None
 1.28A 1cmcA-3kaoA:
undetectable
1cmcB-3kaoA:
undetectable		 1cmcA-3kaoA:
16.31
1cmcB-3kaoA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ALA A  57
GLU A  50
ILE A  49
LEU A  32
THR A  61
 None
 1.29A 1d1gA-3kaoA:
undetectable		 1d1gA-3kaoA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ALA A  57
PHE A  26
ILE A  49
LEU A  32
THR A  61
 None
 1.08A 1ddrB-3kaoA:
undetectable		 1ddrB-3kaoA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ALA A  57
PHE A  26
ILE A  49
LEU A  32
THR A  61
 None
 0.99A 1dhfA-3kaoA:
undetectable		 1dhfA-3kaoA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ALA A  57
PHE A  26
ILE A  49
LEU A  32
THR A  61
 None
 0.88A 1dhfB-3kaoA:
undetectable		 1dhfB-3kaoA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ALA A  57
PHE A  26
ILE A  49
LEU A  32
THR A  61
 None
 1.03A 1dyiA-3kaoA:
undetectable		 1dyiA-3kaoA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ALA A  57
PHE A  26
ILE A  49
LEU A  32
THR A  61
 None
 1.03A 1dyiB-3kaoA:
undetectable		 1dyiB-3kaoA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 9 LEU A  24
ILE A  67
LEU A  32
GLY A  74
ALA A  57
 None
 1.30A 1e7aA-3kaoA:
undetectable		 1e7aA-3kaoA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ALA A  57
PHE A  26
ILE A  49
LEU A  32
THR A  61
 None
 1.11A 1jolA-3kaoA:
undetectable		 1jolA-3kaoA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 11 ALA A  57
PHE A  26
ILE A  49
LEU A  32
THR A  61
 None
 1.11A 1jomA-3kaoA:
undetectable		 1jomA-3kaoA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ALA A  80
GLU A  59
ARG A 301
ARG A 297
LEU A  55
 None
 1.29A 1mj2A-3kaoA:
undetectable
1mj2B-3kaoA:
undetectable		 1mj2A-3kaoA:
18.69
1mj2B-3kaoA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ALA A  80
GLU A  59
ARG A 301
ARG A 297
LEU A  55
 None
 1.25A 1mj2C-3kaoA:
undetectable
1mj2D-3kaoA:
undetectable		 1mj2C-3kaoA:
18.69
1mj2D-3kaoA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ALA A  80
GLU A  59
ARG A 301
ARG A 297
LEU A  55
 None
 1.26A 1mjoC-3kaoA:
undetectable
1mjoD-3kaoA:
undetectable		 1mjoC-3kaoA:
18.69
1mjoD-3kaoA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 9 TYR A 145
ILE A 146
TYR A  91
ILE A 149
GLU A 152
 None
 1.36A 1mrgA-3kaoA:
undetectable		 1mrgA-3kaoA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 8 TYR A 145
ILE A 146
TYR A  91
ILE A 149
GLU A 152
 None
 1.24A 1mrjA-3kaoA:
undetectable		 1mrjA-3kaoA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ALA A  57
PHE A  26
ILE A  49
LEU A  32
THR A  61
 None
 1.03A 1rx8A-3kaoA:
undetectable		 1rx8A-3kaoA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		4 / 5 PRO A 209
VAL A 187
ASN A 188
VAL A 206
 None
 1.03A 1z2bC-3kaoA:
undetectable		 1z2bC-3kaoA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		4 / 6 TYR A 129
GLY A 251
SER A 249
ARG A 278
 None
SO4  A 328 ( 4.5A)
SO4  A 328 (-2.5A)
None
 1.16A 2a3cB-3kaoA:
8.2		 2a3cB-3kaoA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_A_DVAA35_0
(UBIQUITIN)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		4 / 4 GLN A  48
GLU A  50
ILE A  49
PRO A  44
 None
 1.47A 2fcnA-3kaoA:
undetectable		 2fcnA-3kaoA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		4 / 8 GLU A 196
PHE A 199
VAL A 164
TYR A 130
 None
 1.00A 2fl5E-3kaoA:
undetectable
2fl5F-3kaoA:
undetectable		 2fl5E-3kaoA:
19.51
2fl5F-3kaoA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ALA A  57
PHE A  26
ILE A  49
LEU A  32
THR A  61
 None
 0.97A 2w3bA-3kaoA:
undetectable		 2w3bA-3kaoA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ALA A  57
PHE A  26
ILE A  49
LEU A  32
THR A  61
 None
 0.98A 2w3bB-3kaoA:
undetectable		 2w3bB-3kaoA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 VAL A 203
PHE A 257
LEU A 261
ALA A  23
SER A  66
 None
 1.46A 3apvA-3kaoA:
undetectable		 3apvA-3kaoA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		3 / 3 ASN A 211
ASN A 174
GLU A 207
 None
 0.94A 3kpdC-3kaoA:
undetectable		 3kpdC-3kaoA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 11 ALA A  57
PHE A  26
ILE A  49
LEU A  32
THR A  61
 None
 0.93A 3n0hA-3kaoA:
undetectable		 3n0hA-3kaoA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ALA A  57
PHE A  26
ILE A  49
LEU A  32
THR A  61
 None
 1.07A 3ql0A-3kaoA:
undetectable		 3ql0A-3kaoA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 10 ALA A  90
LEU A  68
LEU A  87
ALA A  57
THR A  61
 None
 1.28A 3r9cA-3kaoA:
undetectable		 3r9cA-3kaoA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ALA A  57
PHE A  26
ILE A  49
LEU A  32
THR A  61
 None
 0.94A 3s3vA-3kaoA:
undetectable		 3s3vA-3kaoA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 PHE A 126
PRO A  71
LEU A  75
ALA A 113
SER A 112
 None
 1.42A 4a83A-3kaoA:
undetectable		 4a83A-3kaoA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 PHE A 126
PRO A  71
LEU A  75
ALA A 113
SER A 112
 None
 1.36A 4a84A-3kaoA:
undetectable		 4a84A-3kaoA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		4 / 5 LEU A  68
ILE A  21
ALA A 123
PHE A 161
 None
 0.83A 4dc3B-3kaoA:
undetectable		 4dc3B-3kaoA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ALA A  57
PHE A  26
ILE A  49
LEU A  32
THR A  61
 None
 1.06A 4ej1B-3kaoA:
undetectable		 4ej1B-3kaoA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ALA A  57
PHE A  26
ILE A  49
LEU A  32
THR A  61
 None
 0.97A 4m6kA-3kaoA:
undetectable		 4m6kA-3kaoA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ALA A  57
PHE A  26
ILE A  49
LEU A  32
THR A  61
 None
 1.11A 4pstA-3kaoA:
undetectable		 4pstA-3kaoA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ALA A  57
PHE A  26
ILE A  49
LEU A  32
THR A  61
 None
 1.06A 4psyA-3kaoA:
undetectable		 4psyA-3kaoA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ALA A  57
PHE A  26
ILE A  49
LEU A  32
THR A  61
 None
 1.07A 4qleA-3kaoA:
undetectable		 4qleA-3kaoA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 11 ALA A  57
PHE A  26
ILE A  49
LEU A  32
THR A  61
 None
 1.09A 4qlfA-3kaoA:
undetectable		 4qlfA-3kaoA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ALA A  57
PHE A  26
ILE A  49
LEU A  32
THR A  61
 None
 1.07A 4qlgA-3kaoA:
undetectable		 4qlgA-3kaoA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ALA A  57
PHE A  26
ILE A  49
LEU A  32
THR A  61
 None
 1.09A 4qlgB-3kaoA:
undetectable		 4qlgB-3kaoA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		3 / 3 ARG A  29
GLU A 110
TYR A  73
 SO4  A 327 (-4.6A)
None
None
 0.86A 4r29D-3kaoA:
undetectable		 4r29D-3kaoA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ALA A  57
PHE A  26
ILE A  49
LEU A  32
THR A  61
 None
 1.05A 4rgcA-3kaoA:
undetectable		 4rgcA-3kaoA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ALA A  57
PHE A  26
ILE A  49
LEU A  32
THR A  61
 None
 1.06A 4x5fA-3kaoA:
undetectable		 4x5fA-3kaoA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ALA A  57
PHE A  26
ILE A  49
LEU A  32
THR A  61
 None
 1.06A 4x5fB-3kaoA:
undetectable		 4x5fB-3kaoA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ALA A  57
PHE A  26
ILE A  49
LEU A  32
THR A  61
 None
 1.05A 4x5gA-3kaoA:
undetectable		 4x5gA-3kaoA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ALA A  57
PHE A  26
ILE A  49
LEU A  32
THR A  61
 None
 0.99A 4x5hA-3kaoA:
undetectable		 4x5hA-3kaoA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 9 TYR A 145
ILE A 146
TYR A  91
ILE A 149
GLU A 152
 None
 1.07A 4yp2B-3kaoA:
undetectable		 4yp2B-3kaoA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		4 / 6 SER A 195
PRO A 197
PHE A 199
GLU A 147
 None
 1.29A 5b8iA-3kaoA:
undetectable		 5b8iA-3kaoA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 9 TYR A 145
ILE A 146
TYR A  91
ILE A 149
GLU A 152
 None
 1.07A 5cf9B-3kaoA:
undetectable		 5cf9B-3kaoA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ALA A  57
PHE A  26
ILE A  49
LEU A  32
THR A  61
 None
 1.06A 5eajB-3kaoA:
undetectable		 5eajB-3kaoA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		4 / 7 PRO A 105
TYR A 145
ILE A 149
ILE A 146
 GOL  A 332 (-4.6A)
None
None
None
 0.90A 5murB-3kaoA:
undetectable		 5murB-3kaoA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		4 / 7 THR A  61
LEU A  89
LYS A 117
ASN A 122
 None
 1.02A 5tudA-3kaoA:
undetectable		 5tudA-3kaoA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Staphylococcus
aureus) 		4 / 6 TYR A 145
TYR A  91
ILE A 149
GLU A 152
 None
 1.00A 5z3jA-3kaoA:
undetectable		 5z3jA-3kaoA:
20.87