SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kar'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 3kar KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 649
SER A 713
LEU A 653
ASN A 650
 None
 1.19A 1y0xX-3karA:
undetectable		 1y0xX-3karA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA504_0
(CHORISMATE SYNTHASE)		 3kar KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		4 / 5 SER A 599
HIS A 595
ARG A 585
SER A 601
 None
 1.27A 2qhfA-3karA:
undetectable		 2qhfA-3karA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 3kar KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 394
HIS A 706
SER A 703
ALA A 396
 None
 1.39A 2rk8A-3karA:
undetectable		 2rk8A-3karA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 3kar KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 486
ASN A 448
ARG A 392
 None
None
ADP  A 999 (-2.8A)
 0.81A 2rlcA-3karA:
undetectable		 2rlcA-3karA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3kar KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		4 / 8 SER A 601
HIS A 595
SER A 596
ARG A 585
 None
 1.29A 2vmyA-3karA:
undetectable
2vmyB-3karA:
undetectable		 2vmyA-3karA:
19.81
2vmyB-3karA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 3kar KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 499
LEU A 622
ASN A 623
THR A 557
ILE A 604
 None
 1.15A 2vn0A-3karA:
undetectable		 2vn0A-3karA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 3kar KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 414
THR A 425
GLU A 435
 None
 0.64A 2zifB-3karA:
undetectable		 2zifB-3karA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3kar KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 549
ILE A 560
VAL A 563
PHE A 519
LEU A 684
 None
 1.14A 3em0B-3karA:
1.3		 3em0B-3karA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_B_ETSB303_1
(CARBONIC ANHYDRASE 4)		 3kar KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 467
HIS A 606
ILE A 520
THR A 559
THR A 558
 None
 1.05A 3fw3B-3karA:
undetectable		 3fw3B-3karA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 3kar KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 695
ASP A 626
ILE A 492
GLY A 490
ILE A 470
 None
MG  A 997 ( 3.8A)
None
None
None
 0.89A 3oxxD-3karA:
undetectable		 3oxxD-3karA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)		 3kar KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 711
PHE A 436
PHE A 438
MET A 422
VAL A 424
 None
 1.44A 4c9wA-3karA:
undetectable		 4c9wA-3karA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 3kar KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 401
SER A 403
ARG A 394
SER A 704
 None
 1.32A 4k17B-3karA:
undetectable		 4k17B-3karA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3kar KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 522
ALA A 628
LEU A 656
LEU A 684
ILE A 602
 None
 1.12A 4p66A-3karA:
undetectable		 4p66A-3karA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3kar KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 602
GLU A 521
MET A 484
CYH A 469
LEU A 627
 None
 1.17A 5fhzD-3karA:
undetectable		 5fhzD-3karA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3kar KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 676
ILE A 673
PHE A 675
 None
 0.68A 5kirA-3karA:
undetectable		 5kirA-3karA:
19.78