SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kat'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 3kat NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A1400
LEU A1403
LYS A1428
LEU A1432
VAL A1396
 None
 1.04A 1sn5B-3katA:
undetectable
1sn5D-3katA:
undetectable		 1sn5B-3katA:
20.15
1sn5D-3katA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 3kat NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LYS A1428
LEU A1432
VAL A1396
LEU A1400
LEU A1403
 None
 1.06A 1sn5B-3katA:
undetectable
1sn5D-3katA:
undetectable		 1sn5B-3katA:
20.15
1sn5D-3katA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 3kat NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 9 VAL A1382
HIS A1380
ASP A1383
LEU A1408
ARG A1386
 None
 1.26A 6c2mB-3katA:
undetectable		 6c2mB-3katA:
19.30