SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kb1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 3kb1 NUCLEOTIDE-BINDING
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 10 ASN A 190
VAL A  30
VAL A  35
GLY A  31
LEU A 165
 ADP  A 301 (-2.9A)
ADP  A 301 (-4.4A)
None
ADP  A 301 (-3.1A)
None
 1.38A 1fkoA-3kb1A:
undetectable		 1fkoA-3kb1A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 3kb1 NUCLEOTIDE-BINDING
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 11 ASN A 190
VAL A  30
VAL A  35
GLY A  31
LEU A 165
 ADP  A 301 (-2.9A)
ADP  A 301 (-4.4A)
None
ADP  A 301 (-3.1A)
None
 1.37A 1fkpA-3kb1A:
undetectable		 1fkpA-3kb1A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 3kb1 NUCLEOTIDE-BINDING
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 11 LEU A 145
GLY A 139
ASP A  56
ILE A 158
PRO A 153
 None
 0.99A 1hxwB-3kb1A:
undetectable		 1hxwB-3kb1A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 3kb1 NUCLEOTIDE-BINDING
PROTEIN
(Archaeoglobus
fulgidus) 		6 / 12 LEU A 185
LEU A 133
LEU A  39
LEU A  38
ILE A  90
GLY A  51
 None
 1.38A 2ouzA-3kb1A:
undetectable		 2ouzA-3kb1A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3kb1 NUCLEOTIDE-BINDING
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 10 ASN A 190
VAL A  30
VAL A  35
GLY A  31
LEU A 165
 ADP  A 301 (-2.9A)
ADP  A 301 (-4.4A)
None
ADP  A 301 (-3.1A)
None
 1.33A 3lp1A-3kb1A:
undetectable		 3lp1A-3kb1A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 3kb1 NUCLEOTIDE-BINDING
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 8 ALA A 151
PRO A 153
LEU A  14
LEU A 121
 None
 0.89A 4jjkA-3kb1A:
10.4		 4jjkA-3kb1A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 3kb1 NUCLEOTIDE-BINDING
PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 GLU A 195
ARG A 202
TYR A 193
 None
 0.66A 5trqB-3kb1A:
undetectable		 5trqB-3kb1A:
21.74