SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kb6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 11 LEU A 200
VAL A 235
ILE A 217
VAL A 224
PHE A 249
 None
 1.42A 1gx9A-3kb6A:
undetectable		 1gx9A-3kb6A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 ILE A 147
GLY A 148
GLY A 150
VAL A 172
PRO A 203
 None
NAD  A 400 ( 3.9A)
NAD  A 400 ( 3.3A)
1PE  A 404 (-4.0A)
NAD  A 400 (-3.7A)
 0.99A 1nv8A-3kb6A:
6.5		 1nv8A-3kb6A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 PRO A  98
ILE A 147
GLY A 148
GLY A 150
PRO A 203
 None
None
NAD  A 400 ( 3.9A)
NAD  A 400 ( 3.3A)
NAD  A 400 (-3.7A)
 1.10A 1nv8A-3kb6A:
6.5		 1nv8A-3kb6A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 ILE A 147
GLY A 148
GLY A 150
VAL A 172
PRO A 203
 None
NAD  A 400 ( 3.9A)
NAD  A 400 ( 3.3A)
1PE  A 404 (-4.0A)
NAD  A 400 (-3.7A)
 0.96A 1nv8B-3kb6A:
6.2		 1nv8B-3kb6A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 LEU A  65
LEU A  59
ALA A  43
HIS A  77
ILE A  78
 None
 1.09A 1tw4A-3kb6A:
undetectable		 1tw4A-3kb6A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 11 ILE A 109
LYS A 114
LEU A 110
VAL A 156
PHE A 163
 None
 1.24A 1tw4A-3kb6A:
undetectable		 1tw4A-3kb6A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		6 / 12 ILE A 147
GLY A 148
GLY A 150
SER A 154
VAL A 172
PRO A 203
 None
NAD  A 400 ( 3.9A)
NAD  A 400 ( 3.3A)
None
1PE  A 404 (-4.0A)
NAD  A 400 (-3.7A)
 1.42A 1vq1B-3kb6A:
6.4		 1vq1B-3kb6A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 5 ASP A 177
LEU A 178
LYS A 181
ARG A 175
 None
None
None
PEG  A 701 ( 4.4A)
 1.43A 2gj5A-3kb6A:
undetectable		 2gj5A-3kb6A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 8 TYR A 298
TYR A 297
TYR A  51
HIS A  77
 None
LAC  A 399 ( 4.1A)
PPI  A 453 ( 4.7A)
None
 1.30A 2ha2A-3kb6A:
undetectable		 2ha2A-3kb6A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 8 TYR A 298
TYR A 297
TYR A  51
HIS A  77
 None
LAC  A 399 ( 4.1A)
PPI  A 453 ( 4.7A)
None
 1.38A 2ha2B-3kb6A:
undetectable		 2ha2B-3kb6A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 11 LEU A 200
ILE A 147
GLY A 148
GLY A 153
LEU A 226
 None
None
NAD  A 400 ( 3.9A)
None
None
 0.99A 2qmmA-3kb6A:
undetectable
2qmmB-3kb6A:
2.0		 2qmmA-3kb6A:
22.66
2qmmB-3kb6A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 6 ILE A  78
TYR A  82
ILE A  46
HIS A  69
 None
 1.09A 3eteA-3kb6A:
10.9
3eteE-3kb6A:
10.9		 3eteA-3kb6A:
20.56
3eteE-3kb6A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 5 ILE A  78
TYR A  82
ILE A  46
HIS A  69
 None
 1.11A 3eteB-3kb6A:
10.8
3eteC-3kb6A:
10.8		 3eteB-3kb6A:
20.56
3eteC-3kb6A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 7 ILE A  46
HIS A  69
ILE A  78
TYR A  82
 None
 1.09A 3eteD-3kb6A:
6.5
3eteF-3kb6A:
10.9		 3eteD-3kb6A:
20.56
3eteF-3kb6A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 THR A 292
PHE A 249
GLY A 253
ILE A 198
VAL A 235
 None
 1.23A 3fzgA-3kb6A:
5.0		 3fzgA-3kb6A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 LEU A 265
ASP A  52
PHE A  49
SER A  72
THR A   6
 None
None
PPI  A 398 (-4.0A)
LAC  A 399 (-4.3A)
None
 1.12A 4eckB-3kb6A:
2.3		 4eckB-3kb6A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 11 VAL A 113
ILE A 109
PHE A 163
MET A 165
LEU A 144
 None
 1.39A 4lhmA-3kb6A:
undetectable		 4lhmA-3kb6A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 ALA A 230
LEU A 188
LEU A 192
ILE A 212
THR A 229
 NAD  A 400 (-4.6A)
None
None
None
NAD  A 400 (-4.9A)
 1.00A 4m2xC-3kb6A:
undetectable		 4m2xC-3kb6A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 6 ASP A  76
ALA A 230
THR A 208
TYR A 204
 PPI  A 453 (-3.9A)
NAD  A 400 (-4.6A)
NAD  A 400 (-4.7A)
None
 1.11A 4w5qA-3kb6A:
3.2		 4w5qA-3kb6A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 6 ASP A  76
ALA A 230
THR A 208
TYR A 204
 PPI  A 453 (-3.9A)
NAD  A 400 (-4.6A)
NAD  A 400 (-4.7A)
None
 1.12A 4w5tA-3kb6A:
3.1		 4w5tA-3kb6A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 LEU A  67
ILE A  78
VAL A  48
VAL A  32
LEU A  58
 None
None
None
None
1PE  A 700 (-4.4A)
 1.07A 4y0qA-3kb6A:
undetectable		 4y0qA-3kb6A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		3 / 3 VAL A 311
TYR A  16
ALA A  19
 None
 0.54A 4ybnA-3kb6A:
undetectable		 4ybnA-3kb6A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 6 ASP A  76
ALA A 230
THR A 208
TYR A 204
 PPI  A 453 (-3.9A)
NAD  A 400 (-4.6A)
NAD  A 400 (-4.7A)
None
 1.12A 4z4cA-3kb6A:
3.1		 4z4cA-3kb6A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 6 ASP A  76
ALA A 230
THR A 208
TYR A 204
 PPI  A 453 (-3.9A)
NAD  A 400 (-4.6A)
NAD  A 400 (-4.7A)
None
 1.12A 4z4fA-3kb6A:
3.1		 4z4fA-3kb6A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 5 ASP A  76
ALA A 230
THR A 208
TYR A 204
 PPI  A 453 (-3.9A)
NAD  A 400 (-4.6A)
NAD  A 400 (-4.7A)
None
 1.10A 4z4gA-3kb6A:
3.0		 4z4gA-3kb6A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 5 ASP A  76
ALA A 230
THR A 208
TYR A 204
 PPI  A 453 (-3.9A)
NAD  A 400 (-4.6A)
NAD  A 400 (-4.7A)
None
 1.07A 4z4hA-3kb6A:
3.1		 4z4hA-3kb6A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 6 ASP A  76
ALA A 230
THR A 208
TYR A 204
 PPI  A 453 (-3.9A)
NAD  A 400 (-4.6A)
NAD  A 400 (-4.7A)
None
 1.07A 4z4iA-3kb6A:
3.2		 4z4iA-3kb6A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 ILE A 198
LEU A 252
VAL A 234
VAL A 235
LEU A 191
 None
 1.25A 5bykA-3kb6A:
undetectable		 5bykA-3kb6A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 4 ILE A 227
GLY A 251
ILE A 109
LEU A 252
 None
 0.81A 5dzkl-3kb6A:
undetectable
5dzkz-3kb6A:
undetectable		 5dzkl-3kb6A:
20.81
5dzkz-3kb6A:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		3 / 3 ALA A 273
ASN A 277
LEU A 278
 None
 0.49A 5i1oA-3kb6A:
undetectable		 5i1oA-3kb6A:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 6 TYR A  51
ASP A 255
HIS A 294
TYR A  96
 PPI  A 453 ( 4.7A)
NAD  A 400 (-4.1A)
LAC  A 399 (-3.9A)
LAC  A 399 ( 4.6A)
 1.09A 5ih0A-3kb6A:
undetectable		 5ih0A-3kb6A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 11 LEU A 200
ILE A 147
GLY A 148
GLY A 153
LEU A 226
 None
None
NAD  A 400 ( 3.9A)
None
None
 0.91A 5twjD-3kb6A:
undetectable		 5twjD-3kb6A:
18.64