SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kbg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 3kbg 30S RIBOSOMAL
PROTEIN S4E
(Thermoplasma
acidophilum) 		5 / 12 VAL A  68
ILE A  43
ILE A  44
VAL A  73
LEU A  61
 None
 1.04A 1qhsA-3kbgA:
undetectable		 1qhsA-3kbgA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 3kbg 30S RIBOSOMAL
PROTEIN S4E
(Thermoplasma
acidophilum) 		4 / 7 PHE A 217
TYR A  97
ASN A 184
VAL A  95
 None
 0.93A 1wu8A-3kbgA:
undetectable
1wu8C-3kbgA:
undetectable		 1wu8A-3kbgA:
25.27
1wu8C-3kbgA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 3kbg 30S RIBOSOMAL
PROTEIN S4E
(Thermoplasma
acidophilum) 		4 / 7 LEU A 202
THR A 211
HIS A 182
GLY A 187
 None
 0.82A 2ddwB-3kbgA:
undetectable		 2ddwB-3kbgA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 3kbg 30S RIBOSOMAL
PROTEIN S4E
(Thermoplasma
acidophilum) 		5 / 9 ILE A 219
ILE A 177
GLY A 187
ALA A 175
THR A 178
 None
 1.34A 2dtjA-3kbgA:
undetectable
2dtjB-3kbgA:
undetectable		 2dtjA-3kbgA:
26.43
2dtjB-3kbgA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3kbg 30S RIBOSOMAL
PROTEIN S4E
(Thermoplasma
acidophilum) 		5 / 12 ASN A 184
VAL A 183
GLY A 101
ALA A 179
GLN A  36
 None
 1.04A 2x2iA-3kbgA:
undetectable		 2x2iA-3kbgA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3kbg 30S RIBOSOMAL
PROTEIN S4E
(Thermoplasma
acidophilum) 		5 / 12 ASN A 184
VAL A 183
GLY A 101
ALA A 179
GLN A  36
 None
 1.09A 2x2iC-3kbgA:
2.4		 2x2iC-3kbgA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_A_URFA521_1
(RNA DEPENDENT RNA
POLYMERASE)		 3kbg 30S RIBOSOMAL
PROTEIN S4E
(Thermoplasma
acidophilum) 		4 / 5 ASP A 137
ASP A  69
ASP A  84
ARG A  94
 None
 1.35A 3naiA-3kbgA:
undetectable		 3naiA-3kbgA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 3kbg 30S RIBOSOMAL
PROTEIN S4E
(Thermoplasma
acidophilum) 		5 / 12 ARG A 139
VAL A  95
LEU A  40
VAL A  73
GLY A  70
 None
 1.42A 5i8fA-3kbgA:
undetectable		 5i8fA-3kbgA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 3kbg 30S RIBOSOMAL
PROTEIN S4E
(Thermoplasma
acidophilum) 		5 / 12 LEU A  41
LEU A  48
ALA A  57
ASN A  89
ILE A  86
 None
 1.12A 5xiwD-3kbgA:
undetectable		 5xiwD-3kbgA:
16.50