SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kbh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		5 / 12 THR A 371
HIS A 374
GLU A 375
HIS A 378
GLU A 402
 None
 0.53A 1j36A-3kbhA:
41.9		 1j36A-3kbhA:
36.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		5 / 12 THR A 371
HIS A 374
GLU A 375
HIS A 378
GLU A 402
 None
 0.53A 1j36B-3kbhA:
41.9		 1j36B-3kbhA:
36.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		5 / 11 HIS A 374
GLU A 375
HIS A 378
GLU A 402
PHE A 274
 None
 0.75A 1j37A-3kbhA:
41.8		 1j37A-3kbhA:
36.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		5 / 11 HIS A 374
GLU A 375
HIS A 378
GLU A 402
PHE A 274
 None
 0.74A 1j37B-3kbhA:
41.8		 1j37B-3kbhA:
36.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		4 / 7 LEU A 456
ILE A 446
THR A 449
GLN A 522
 None
 1.13A 1kglA-3kbhA:
undetectable		 1kglA-3kbhA:
12.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		5 / 12 HIS A 374
GLU A 375
HIS A 378
GLU A 402
PHE A 274
 None
 0.74A 1o86A-3kbhA:
45.0		 1o86A-3kbhA:
42.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_D_MTXD354_1
(PTERIDINE REDUCTASE
1)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		5 / 12 SER A 409
PRO A 415
ASP A 367
LEU A 444
TYR A 279
 None
 1.26A 1p33D-3kbhA:
undetectable		 1p33D-3kbhA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		4 / 5 LYS A  68
LEU A  39
ALA A  65
SER A  44
 None
 1.08A 1tt6B-3kbhA:
undetectable		 1tt6B-3kbhA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		4 / 7 ALA A 533
ILE A 544
ILE A 407
PHE A 525
 None
 0.94A 1upfB-3kbhA:
undetectable		 1upfB-3kbhA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		5 / 12 LEU A 554
ILE A 407
GLY A 405
HIS A 401
ASP A 382
 None
 1.10A 1zz1C-3kbhA:
undetectable		 1zz1C-3kbhA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		4 / 6 LEU A 267
LEU A 266
LEU A 281
LEU A 444
 None
 0.90A 2ab2A-3kbhA:
undetectable		 2ab2A-3kbhA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 3kbh SPIKE GLYCOPROTEIN
(Human
coronavirus
NL63) 		5 / 12 GLY E 594
ALA E 489
THR E 490
ALA E 491
ALA E 583
 None
 0.95A 2gluB-3kbhE:
undetectable		 2gluB-3kbhE:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		4 / 8 THR A 334
VAL A 364
PHE A 308
ALA A 372
 None
 1.16A 2ij7C-3kbhA:
undetectable		 2ij7C-3kbhA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		4 / 8 THR A 371
HIS A 374
GLU A 375
HIS A 378
 None
 0.36A 2jihB-3kbhA:
undetectable		 2jihB-3kbhA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		4 / 5 ALA A 396
ALA A 569
GLN A 524
VAL A 573
 None
 0.94A 2nyrB-3kbhA:
undetectable		 2nyrB-3kbhA:
19.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		5 / 11 HIS A 374
GLU A 375
HIS A 378
GLU A 402
PHE A 274
 None
 0.72A 2x8zA-3kbhA:
28.9		 2x8zA-3kbhA:
35.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		5 / 12 ASN A  33
THR A  92
VAL A  93
GLN A  96
LEU A  97
 None
 0.94A 2xrlA-3kbhA:
undetectable		 2xrlA-3kbhA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		4 / 7 ASN A 556
ALA A 532
ALA A 528
GLN A 552
 None
 0.83A 3a2qA-3kbhA:
undetectable		 3a2qA-3kbhA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		3 / 3 HIS A 374
GLU A 375
HIS A 378
 None
 0.18A 3kecB-3kbhA:
undetectable		 3kecB-3kbhA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		3 / 3 HIS A 374
PHE A 314
PHE A 315
 None
 0.67A 3lk0D-3kbhA:
undetectable		 3lk0D-3kbhA:
9.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		5 / 11 HIS A 374
GLU A 375
HIS A 378
GLU A 402
PHE A 274
 None
 0.70A 4c2pA-3kbhA:
45.7		 4c2pA-3kbhA:
42.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		4 / 6 LYS A  68
LEU A  39
ALA A  65
SER A  44
 None
 1.05A 4d7bB-3kbhA:
undetectable		 4d7bB-3kbhA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		3 / 3 ARG A 245
THR A 608
TRP A 606
 None
 1.03A 4d7hA-3kbhA:
undetectable		 4d7hA-3kbhA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		4 / 8 GLY A 405
VAL A 404
HIS A 401
ILE A 379
 None
 0.89A 4fglD-3kbhA:
undetectable		 4fglD-3kbhA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		3 / 3 LYS A  68
LEU A  39
ALA A  65
 None
 0.72A 4iizA-3kbhA:
undetectable		 4iizA-3kbhA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		3 / 3 GLU A 406
ARG A 518
GLN A 442
 None
 0.84A 4rtbA-3kbhA:
undetectable		 4rtbA-3kbhA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		3 / 3 ARG A 245
THR A 608
TRP A 606
 None
 1.03A 4ug5A-3kbhA:
undetectable		 4ug5A-3kbhA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		3 / 3 ARG A 245
THR A 608
TRP A 606
 None
 1.04A 4uglA-3kbhA:
undetectable		 4uglA-3kbhA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		4 / 7 GLY A 173
GLN A 175
TYR A 127
SER A 502
 None
 1.15A 4ws0A-3kbhA:
undetectable		 4ws0A-3kbhA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		5 / 12 ILE A 407
VAL A 574
GLY A 551
MET A 557
LEU A 558
 None
 0.82A 5byjA-3kbhA:
undetectable		 5byjA-3kbhA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		3 / 3 ARG A 245
THR A 608
TRP A 606
 None
 1.03A 5g6cA-3kbhA:
undetectable		 5g6cA-3kbhA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		4 / 6 LYS A  68
LEU A  39
ALA A  65
SER A  44
 None
 1.02A 5l4iA-3kbhA:
undetectable		 5l4iA-3kbhA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		4 / 6 LYS A  68
LEU A  39
ALA A  65
SER A  44
 None
 1.04A 5l4iB-3kbhA:
undetectable		 5l4iB-3kbhA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		5 / 10 ILE A 223
VAL A 226
ASP A 206
TRP A 203
ILE A 513
 None
 1.20A 5lg3G-3kbhA:
1.6		 5lg3G-3kbhA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		5 / 10 ILE A 223
VAL A 226
ASP A 206
TRP A 203
ILE A 513
 None
 1.18A 5lg3H-3kbhA:
2.4		 5lg3H-3kbhA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		5 / 12 ILE A 223
ASN A 397
ASP A 206
TRP A 203
ILE A 513
 None
 1.14A 5lg3J-3kbhA:
1.9		 5lg3J-3kbhA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		4 / 4 GLN A 325
THR A 324
GLU A 312
LEU A 333
 None
 1.37A 5m66A-3kbhA:
undetectable		 5m66A-3kbhA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		5 / 12 GLY A 377
GLN A 380
PHE A 314
GLN A 526
LEU A 529
 None
 1.49A 5uc3B-3kbhA:
undetectable		 5uc3B-3kbhA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens) 		5 / 12 TYR A 237
PHE A 523
ALA A 242
THR A 282
LEU A 444
 None
 1.20A 6aybA-3kbhA:
2.4		 6aybA-3kbhA:
21.50