SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kc2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 3kc2 UNCHARACTERIZED
PROTEIN YKR070W
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 111
VAL A 107
ILE A  79
GLY A  56
 None
 0.84A 11gsA-3kc2A:
undetectable		 11gsA-3kc2A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3kc2 UNCHARACTERIZED
PROTEIN YKR070W
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 111
VAL A 107
ILE A  79
GLY A  56
 None
 0.84A 2gssA-3kc2A:
undetectable		 2gssA-3kc2A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3kc2 UNCHARACTERIZED
PROTEIN YKR070W
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 111
VAL A 107
ILE A  79
GLY A  56
 None
 0.84A 2gssB-3kc2A:
undetectable		 2gssB-3kc2A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3kc2 UNCHARACTERIZED
PROTEIN YKR070W
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  15
LEU A  41
PHE A 294
SER A 314
LEU A 335
 None
 1.10A 2oipB-3kc2A:
undetectable		 2oipB-3kc2A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 3kc2 UNCHARACTERIZED
PROTEIN YKR070W
(Saccharomyces
cerevisiae) 		5 / 11 LEU A  97
VAL A  99
GLY A 100
VAL A 104
ILE A 122
 None
 1.17A 2yy8A-3kc2A:
4.5
2yy8B-3kc2A:
4.2		 2yy8A-3kc2A:
20.98
2yy8B-3kc2A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 3kc2 UNCHARACTERIZED
PROTEIN YKR070W
(Saccharomyces
cerevisiae) 		4 / 8 ALA A  34
ALA A  37
ILE A  31
THR A 319
 None
 0.82A 3dtuC-3kc2A:
undetectable
3dtuD-3kc2A:
undetectable		 3dtuC-3kc2A:
20.93
3dtuD-3kc2A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3kc2 UNCHARACTERIZED
PROTEIN YKR070W
(Saccharomyces
cerevisiae) 		5 / 12 ASN A  42
LEU A  41
VAL A 296
LEU A  24
THR A 347
 None
 0.97A 3fl9B-3kc2A:
undetectable		 3fl9B-3kc2A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3kc2 UNCHARACTERIZED
PROTEIN YKR070W
(Saccharomyces
cerevisiae) 		5 / 12 ASN A  42
LEU A  41
VAL A 296
LEU A  24
THR A 347
 None
 0.98A 3fl9G-3kc2A:
2.3		 3fl9G-3kc2A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3kc2 UNCHARACTERIZED
PROTEIN YKR070W
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 111
VAL A 107
ILE A  79
GLY A  56
 None
 0.83A 3gssA-3kc2A:
undetectable		 3gssA-3kc2A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3kc2 UNCHARACTERIZED
PROTEIN YKR070W
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 111
VAL A 107
ILE A  79
GLY A  56
 None
 0.83A 3gssB-3kc2A:
undetectable		 3gssB-3kc2A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3kc2 UNCHARACTERIZED
PROTEIN YKR070W
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  15
LEU A  41
PHE A 294
SER A 314
LEU A 335
 None
 1.11A 3hj3B-3kc2A:
undetectable		 3hj3B-3kc2A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 3kc2 UNCHARACTERIZED
PROTEIN YKR070W
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 111
VAL A 107
ILE A  79
GLY A  56
 None
 0.82A 3n9jA-3kc2A:
undetectable		 3n9jA-3kc2A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 3kc2 UNCHARACTERIZED
PROTEIN YKR070W
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 242
THR A 243
PHE A 202
LEU A 159
 None
 1.20A 3qelC-3kc2A:
5.7		 3qelC-3kc2A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 3kc2 UNCHARACTERIZED
PROTEIN YKR070W
(Saccharomyces
cerevisiae) 		4 / 8 GLY A  55
THR A 101
ASN A 162
ARG A  62
 None
 1.23A 4m5mA-3kc2A:
undetectable		 4m5mA-3kc2A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3kc2 UNCHARACTERIZED
PROTEIN YKR070W
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  50
ALA A 210
GLY A  33
ALA A  34
LEU A  38
 None
 1.08A 5jw1B-3kc2A:
undetectable		 5jw1B-3kc2A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 3kc2 UNCHARACTERIZED
PROTEIN YKR070W
(Saccharomyces
cerevisiae) 		4 / 7 GLY A  55
PHE A 161
SER A 103
ASN A 204
 None
 0.99A 5n5dB-3kc2A:
3.5		 5n5dB-3kc2A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 3kc2 UNCHARACTERIZED
PROTEIN YKR070W
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 186
LEU A 185
ARG A 189
GLY A 183
 None
 1.08A 5o4yA-3kc2A:
undetectable		 5o4yA-3kc2A:
3.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 3kc2 UNCHARACTERIZED
PROTEIN YKR070W
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 221
LEU A 225
TRP A 209
ASP A  21
VAL A 227
 None
PO4  A 354 (-4.6A)
None
PO4  A 353 ( 3.6A)
None
 1.13A 6mhtA-3kc2A:
2.3		 6mhtA-3kc2A:
21.32