SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kcu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3kcu PROBABLE FORMATE
TRANSPORTER 1
(Escherichia
coli) 		4 / 8 GLY A 271
GLY A 267
GLY A 266
LEU A 268
 None
 0.67A 1qzzA-3kcuA:
undetectable		 1qzzA-3kcuA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3kcu PROBABLE FORMATE
TRANSPORTER 1
(Escherichia
coli) 		5 / 12 ILE A 263
ILE A 169
VAL A 165
ALA A 164
PHE A 161
 None
 1.02A 1uduB-3kcuA:
undetectable		 1uduB-3kcuA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3kcu PROBABLE FORMATE
TRANSPORTER 1
(Escherichia
coli) 		5 / 12 ALA A  87
GLY A  42
THR A  40
LEU A 122
VAL A 123
 None
 1.19A 2zifB-3kcuA:
undetectable		 2zifB-3kcuA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3kcu PROBABLE FORMATE
TRANSPORTER 1
(Escherichia
coli) 		5 / 12 PHE A 128
ALA A 125
ASN A 121
GLY A 120
LEU A  89
 None
 1.00A 3aobC-3kcuA:
1.9		 3aobC-3kcuA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3kcu PROBABLE FORMATE
TRANSPORTER 1
(Escherichia
coli) 		5 / 12 PHE A 215
ALA A 125
ASN A 121
GLY A 120
LEU A  89
 None
 1.41A 3aobC-3kcuA:
1.9		 3aobC-3kcuA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 3kcu PROBABLE FORMATE
TRANSPORTER 1
(Escherichia
coli) 		4 / 8 PHE A  49
THR A  54
ILE A  53
THR A  56
 None
 0.91A 3bpxA-3kcuA:
undetectable
3bpxB-3kcuA:
undetectable		 3bpxA-3kcuA:
15.79
3bpxB-3kcuA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 3kcu PROBABLE FORMATE
TRANSPORTER 1
(Escherichia
coli) 		5 / 12 GLY A  72
GLY A  71
ALA A  67
VAL A 203
PRO A 198
 None
 1.00A 3jb2A-3kcuA:
undetectable		 3jb2A-3kcuA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3kcu PROBABLE FORMATE
TRANSPORTER 1
(Escherichia
coli) 		5 / 12 ALA A 227
GLY A 143
GLY A 146
ASN A 142
GLY A 236
 None
 1.18A 4n48B-3kcuA:
undetectable		 4n48B-3kcuA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3kcu PROBABLE FORMATE
TRANSPORTER 1
(Escherichia
coli) 		4 / 4 VAL A 149
ILE A 221
ASN A 213
VAL A 157
 None
 1.07A 5ajqA-3kcuA:
undetectable		 5ajqA-3kcuA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3kcu PROBABLE FORMATE
TRANSPORTER 1
(Escherichia
coli) 		5 / 12 VAL A  83
ALA A  48
VAL A 199
ALA A 178
SER A 182
 None
 1.02A 5jw1A-3kcuA:
undetectable		 5jw1A-3kcuA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 3kcu PROBABLE FORMATE
TRANSPORTER 1
(Escherichia
coli) 		4 / 5 PHE A  75
PHE A  51
LEU A  77
LEU A  69
 None
 0.83A 5veuH-3kcuA:
1.8		 5veuH-3kcuA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 3kcu PROBABLE FORMATE
TRANSPORTER 1
(Escherichia
coli) 		5 / 10 TYR A 138
ILE A 223
LEU A 150
ASN A 142
ALA A 234
 None
 1.24A 5y7pB-3kcuA:
undetectable		 5y7pB-3kcuA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 3kcu PROBABLE FORMATE
TRANSPORTER 1
(Escherichia
coli) 		5 / 10 TYR A 138
ILE A 223
LEU A 150
ASN A 142
ALA A 234
 None
 1.26A 5y7pD-3kcuA:
undetectable		 5y7pD-3kcuA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3kcu PROBABLE FORMATE
TRANSPORTER 1
(Escherichia
coli) 		3 / 3 ASN A 241
VAL A 157
HIS A 244
 None
 0.85A 6a5yD-3kcuA:
undetectable		 6a5yD-3kcuA:
13.48