SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kcx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR
(Homo
sapiens) 		4 / 8 LEU A  81
VAL A 154
GLY A 155
LEU A 187
 None
 0.93A 1jlbA-3kcxA:
undetectable		 1jlbA-3kcxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR
(Homo
sapiens) 		4 / 6 ARG A  44
GLY A 266
ASP A 269
TRP A  27
 None
 1.38A 1kf6M-3kcxA:
undetectable
1kf6N-3kcxA:
undetectable		 1kf6M-3kcxA:
18.09
1kf6N-3kcxA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR
(Homo
sapiens) 		5 / 12 LEU A 187
GLY A 266
GLY A 268
ILE A 291
THR A 196
 None
None
None
None
CQL  A   1 (-3.8A)
 1.05A 1p91B-3kcxA:
undetectable		 1p91B-3kcxA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR
(Homo
sapiens) 		5 / 9 LEU A 146
ILE A 189
GLY A 190
SER A  91
LEU A 186
 None
 1.15A 2qmmA-3kcxA:
undetectable		 2qmmA-3kcxA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR
(Homo
sapiens) 		5 / 9 LEU A 146
ILE A 189
GLY A 190
SER A  91
LEU A 186
 None
 1.09A 3ai9X-3kcxA:
undetectable		 3ai9X-3kcxA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR
(Homo
sapiens) 		5 / 12 GLY A 190
SER A 283
ASN A 194
ARG A  33
ILE A 289
 None
 1.27A 3k13A-3kcxA:
undetectable		 3k13A-3kcxA:
22.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR
(Homo
sapiens) 		10 / 10 TYR A 145
LEU A 188
THR A 196
HIS A 199
ASP A 201
LYS A 214
ILE A 273
HIS A 279
ILE A 281
TRP A 296
 None
CQL  A   1 (-4.7A)
CQL  A   1 (-3.8A)
FE2  A1350 ( 3.2A)
FE2  A1350 (-2.5A)
CQL  A   1 (-3.6A)
CQL  A   1 (-4.8A)
CQL  A   1 ( 3.2A)
CQL  A   1 (-3.4A)
CQL  A   1 (-4.7A)
 0.02A 3kcxA-3kcxA:
54.5		 3kcxA-3kcxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR
(Homo
sapiens) 		4 / 7 ARG A  40
GLY A 260
ILE A 217
GLU A 262
 None
 1.07A 4g0vA-3kcxA:
undetectable		 4g0vA-3kcxA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR
(Homo
sapiens) 		3 / 3 PRO A 235
MET A 108
TYR A 103
 None
 0.83A 4qa0B-3kcxA:
undetectable		 4qa0B-3kcxA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR
(Homo
sapiens) 		3 / 3 PRO A 235
MET A 108
TYR A 103
 None
 0.81A 4qa0A-3kcxA:
undetectable		 4qa0A-3kcxA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR
(Homo
sapiens) 		3 / 3 PRO A 235
MET A 108
TYR A 103
 None
 0.91A 4qa2B-3kcxA:
undetectable		 4qa2B-3kcxA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR
(Homo
sapiens) 		3 / 3 ASP A 161
VAL A 154
LEU A 150
 None
 0.62A 5e5jB-3kcxA:
undetectable		 5e5jB-3kcxA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR
(Homo
sapiens) 		4 / 7 ALA A 317
TYR A 200
VAL A 232
GLU A 323
 None
 1.10A 5ecnA-3kcxA:
undetectable		 5ecnA-3kcxA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR
(Homo
sapiens) 		5 / 12 ASP A  49
GLU A  53
LEU A  69
PHE A 206
ARG A 177
 None
 1.11A 5nd7B-3kcxA:
undetectable		 5nd7B-3kcxA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR
(Homo
sapiens) 		3 / 3 MET A 191
GLU A 141
ARG A 143
 None
 0.86A 5tjyA-3kcxA:
undetectable		 5tjyA-3kcxA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR
(Homo
sapiens) 		3 / 3 MET A 191
GLU A 141
ARG A 143
 None
 0.87A 5tjzA-3kcxA:
undetectable		 5tjzA-3kcxA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_1
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR
(Homo
sapiens) 		5 / 12 ASN A 294
THR A 149
LEU A 186
SER A 240
ARG A 238
 CQL  A   1 ( 4.8A)
None
None
None
None
 1.34A 6baaE-3kcxA:
undetectable		 6baaE-3kcxA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_1
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR
(Homo
sapiens) 		5 / 12 ASN A 294
THR A 149
LEU A 186
SER A 240
ARG A 238
 CQL  A   1 ( 4.8A)
None
None
None
None
 1.34A 6baaF-3kcxA:
undetectable		 6baaF-3kcxA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_1
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR
(Homo
sapiens) 		5 / 12 ASN A 294
THR A 149
LEU A 186
SER A 240
ARG A 238
 CQL  A   1 ( 4.8A)
None
None
None
None
 1.35A 6baaG-3kcxA:
undetectable		 6baaG-3kcxA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_1
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR
(Homo
sapiens) 		5 / 12 ASN A 294
THR A 149
LEU A 186
SER A 240
ARG A 238
 CQL  A   1 ( 4.8A)
None
None
None
None
 1.35A 6baaH-3kcxA:
undetectable		 6baaH-3kcxA:
12.96