SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kd4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 3kd4 PUTATIVE PROTEASE
(Parabacteroides
distasonis) 		4 / 7 LYS A 394
THR A 449
THR A 492
VAL A 490
 None
 0.85A 1ictD-3kd4A:
undetectable		 1ictD-3kd4A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 3kd4 PUTATIVE PROTEASE
(Parabacteroides
distasonis) 		4 / 5 LEU A 149
ALA A 226
TRP A 200
LEU A 224
 GOL  A   7 (-4.2A)
None
None
None
 1.23A 2oaxA-3kd4A:
undetectable		 2oaxA-3kd4A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 3kd4 PUTATIVE PROTEASE
(Parabacteroides
distasonis) 		4 / 7 ASP A 374
TYR A 332
PRO A 333
THR A 338
 None
 1.45A 2q6kA-3kd4A:
undetectable		 2q6kA-3kd4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3kd4 PUTATIVE PROTEASE
(Parabacteroides
distasonis) 		4 / 7 TYR A 114
VAL A 294
TYR A 305
ILE A 311
 None
None
None
GOL  A 530 ( 4.9A)
 1.36A 2xz5B-3kd4A:
2.5
2xz5E-3kd4A:
undetectable		 2xz5B-3kd4A:
17.29
2xz5E-3kd4A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3kd4 PUTATIVE PROTEASE
(Parabacteroides
distasonis) 		5 / 12 GLY A 426
ILE A 444
LEU A 495
LEU A 511
VAL A 508
 None
 1.26A 3adsB-3kd4A:
undetectable		 3adsB-3kd4A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 3kd4 PUTATIVE PROTEASE
(Parabacteroides
distasonis) 		4 / 6 LEU A 239
GLY A 342
LEU A 379
SER A 380
 None
 0.93A 3aiaA-3kd4A:
undetectable		 3aiaA-3kd4A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3kd4 PUTATIVE PROTEASE
(Parabacteroides
distasonis) 		5 / 12 THR A 354
VAL A 355
VAL A 376
ILE A 384
THR A 368
 None
 1.11A 3elzA-3kd4A:
undetectable		 3elzA-3kd4A:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3kd4 PUTATIVE PROTEASE
(Parabacteroides
distasonis) 		5 / 11 THR A 354
VAL A 355
VAL A 376
ILE A 384
THR A 368
 None
 1.20A 3elzB-3kd4A:
0.6		 3elzB-3kd4A:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3kd4 PUTATIVE PROTEASE
(Parabacteroides
distasonis) 		5 / 12 THR A 354
VAL A 355
VAL A 376
ILE A 384
THR A 368
 None
 1.33A 3elzC-3kd4A:
undetectable		 3elzC-3kd4A:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3kd4 PUTATIVE PROTEASE
(Parabacteroides
distasonis) 		5 / 12 THR A 354
VAL A 355
VAL A 376
ILE A 384
THR A 368
 None
 1.14A 3em0A-3kd4A:
0.5		 3em0A-3kd4A:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 3kd4 PUTATIVE PROTEASE
(Parabacteroides
distasonis) 		3 / 3 ASP A 150
LEU A  38
VAL A 198
 GOL  A   7 (-4.8A)
None
None
 0.58A 4jecB-3kd4A:
undetectable		 4jecB-3kd4A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 3kd4 PUTATIVE PROTEASE
(Parabacteroides
distasonis) 		5 / 11 ASN A 316
THR A 382
SER A 378
GLY A 381
ASP A 240
 None
 1.49A 4xt7A-3kd4A:
undetectable		 4xt7A-3kd4A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 3kd4 PUTATIVE PROTEASE
(Parabacteroides
distasonis) 		5 / 10 ARG A 154
VAL A  70
ILE A  69
TYR A 137
LEU A 135
 None
 1.07A 5hw8C-3kd4A:
undetectable
5hw8H-3kd4A:
undetectable		 5hw8C-3kd4A:
14.37
5hw8H-3kd4A:
14.37