SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kd8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		4 / 6 LEU A   9
ASP A  14
MET A  46
HIS A  61
 None
 1.21A 1errB-3kd8A:
undetectable		 1errB-3kd8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		5 / 12 ILE A 390
GLY A  44
SER A 375
ASN A  43
ILE A 355
 None
 1.30A 2e7fA-3kd8A:
undetectable		 2e7fA-3kd8A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		5 / 12 ILE A 390
GLY A  44
SER A 375
ASN A  43
ILE A 355
 None
 1.29A 2e7fB-3kd8A:
undetectable		 2e7fB-3kd8A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		4 / 7 SER A 134
ASP A 129
SER A 150
VAL A 148
 None
 1.03A 2hdnE-3kd8A:
undetectable
2hdnF-3kd8A:
undetectable
2hdnH-3kd8A:
undetectable		 2hdnE-3kd8A:
6.17
2hdnF-3kd8A:
23.09
2hdnH-3kd8A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		4 / 7 SER A 150
VAL A 148
SER A 134
ASP A 129
 None
 1.02A 2hdnF-3kd8A:
undetectable
2hdnG-3kd8A:
undetectable
2hdnH-3kd8A:
undetectable		 2hdnF-3kd8A:
23.09
2hdnG-3kd8A:
6.17
2hdnH-3kd8A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		4 / 6 SER A 134
ASP A 129
SER A 150
VAL A 148
 None
 1.03A 2hdnI-3kd8A:
undetectable
2hdnJ-3kd8A:
undetectable
2hdnL-3kd8A:
undetectable		 2hdnI-3kd8A:
6.17
2hdnJ-3kd8A:
23.09
2hdnL-3kd8A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		4 / 6 SER A 150
VAL A 148
SER A 134
ASP A 129
 None
 1.08A 2hdnJ-3kd8A:
undetectable
2hdnK-3kd8A:
undetectable
2hdnL-3kd8A:
undetectable		 2hdnJ-3kd8A:
23.09
2hdnK-3kd8A:
6.17
2hdnL-3kd8A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		4 / 4 LEU A  34
ILE A   7
ILE A 278
ALA A 320
 None
 0.79A 2i30A-3kd8A:
undetectable		 2i30A-3kd8A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		4 / 5 LEU A   9
ASP A  14
MET A  46
HIS A  61
 None
 1.25A 2jfaA-3kd8A:
undetectable		 2jfaA-3kd8A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		3 / 3 ASP A 351
THR A  24
PRO A  25
 None
 0.70A 2pynB-3kd8A:
undetectable		 2pynB-3kd8A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		3 / 3 ASP A 351
THR A  24
PRO A  25
 None
 0.66A 2q64B-3kd8A:
undetectable		 2q64B-3kd8A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		4 / 5 LEU A   9
ASP A  14
MET A  46
HIS A  61
 None
 1.19A 2qxsA-3kd8A:
undetectable		 2qxsA-3kd8A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		4 / 5 LEU A   9
ASP A  14
MET A  46
HIS A  61
 None
 1.21A 2qxsB-3kd8A:
undetectable		 2qxsB-3kd8A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		5 / 10 VAL A 137
ILE A 126
LEU A 198
GLY A 215
ALA A 112
 None
 1.26A 2xf3A-3kd8A:
undetectable		 2xf3A-3kd8A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		5 / 12 ILE A 382
PHE A 357
LEU A  12
ILE A 355
MET A  46
 None
 1.24A 2xkwB-3kd8A:
undetectable		 2xkwB-3kd8A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		5 / 12 ILE A 390
GLY A  44
SER A 375
ASN A  43
ILE A 355
 None
 1.27A 2ycjA-3kd8A:
undetectable		 2ycjA-3kd8A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		5 / 12 GLY A  75
GLY A  77
ALA A  81
LEU A  82
PRO A 227
 None
 0.95A 2zulA-3kd8A:
2.0		 2zulA-3kd8A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		5 / 12 GLY A  75
GLY A  77
ALA A  81
LEU A  82
PRO A 227
 None
 0.97A 3dmhA-3kd8A:
2.0		 3dmhA-3kd8A:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		3 / 3 SER A 179
ASP A 181
ASP A 156
 None
 0.76A 3iv6A-3kd8A:
undetectable		 3iv6A-3kd8A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		3 / 3 SER A 179
ASP A 181
ASP A 156
 None
 0.77A 3iv6C-3kd8A:
undetectable		 3iv6C-3kd8A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		4 / 6 HIS A  61
VAL A 387
LEU A  26
ILE A 295
 None
 0.98A 3kk6A-3kd8A:
undetectable		 3kk6A-3kd8A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		5 / 10 ILE A  42
ASP A 365
LEU A 391
ILE A 278
ILE A 317
 None
 1.23A 3prsA-3kd8A:
undetectable		 3prsA-3kd8A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		4 / 7 VAL A 220
LEU A 191
TYR A 190
LEU A 154
 None
 1.00A 3qeoB-3kd8A:
undetectable		 3qeoB-3kd8A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		5 / 11 GLY A 113
THR A 101
GLY A 215
ARG A 207
PRO A 214
 None
 1.39A 3t8nD-3kd8A:
undetectable
3t8nF-3kd8A:
undetectable		 3t8nD-3kd8A:
15.91
3t8nF-3kd8A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		3 / 3 ASP A 351
THR A  24
PRO A  25
 None
 0.61A 3tkgD-3kd8A:
undetectable		 3tkgD-3kd8A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		3 / 3 ARG A 221
HIS A 164
SER A 222
 None
 1.01A 4mjwA-3kd8A:
undetectable
4mjwB-3kd8A:
2.3		 4mjwA-3kd8A:
22.36
4mjwB-3kd8A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		3 / 3 SER A 222
ARG A 221
HIS A 164
 None
 0.98A 4mjwA-3kd8A:
undetectable
4mjwB-3kd8A:
2.3		 4mjwA-3kd8A:
22.36
4mjwB-3kd8A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		4 / 5 GLY A 224
ALA A 223
GLY A  77
PRO A  78
 None
 0.91A 4u9uA-3kd8A:
undetectable		 4u9uA-3kd8A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		4 / 5 GLY A 224
ALA A 223
GLY A  77
PRO A  78
 None
 0.94A 4u9uB-3kd8A:
undetectable		 4u9uB-3kd8A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		4 / 4 GLU A 171
PRO A 170
ILE A 107
LEU A 168
 None
 0.99A 5m45A-3kd8A:
undetectable		 5m45A-3kd8A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		4 / 4 GLU A 171
PRO A 170
ILE A 107
LEU A 168
 None
 1.08A 5m45D-3kd8A:
1.7		 5m45D-3kd8A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		4 / 4 GLU A 171
PRO A 170
ILE A 107
LEU A 168
 None
 0.98A 5m45G-3kd8A:
undetectable		 5m45G-3kd8A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		4 / 4 GLU A 171
PRO A 170
ILE A 107
LEU A 168
 None
 1.07A 5m45J-3kd8A:
undetectable		 5m45J-3kd8A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		4 / 8 PHE A 135
LEU A 147
ASN A 188
VAL A 186
 None
 0.86A 5nujA-3kd8A:
undetectable		 5nujA-3kd8A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		5 / 11 LEU A 218
GLY A 215
LEU A 147
ARG A 144
ALA A  97
 None
 1.09A 5o96A-3kd8A:
2.0
5o96B-3kd8A:
undetectable		 5o96A-3kd8A:
21.79
5o96B-3kd8A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Thermoplasma
acidophilum) 		4 / 8 VAL A 244
HIS A  61
GLY A  83
LEU A  82
 None
 0.88A 5w3jB-3kd8A:
undetectable		 5w3jB-3kd8A:
23.49