SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kd9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 3kd9 COENZYME A DISULFIDE
REDUCTASE
(Pyrococcus
horikoshii) 		5 / 9 LEU A 440
VAL A 388
GLY A 387
ALA A 402
LEU A 433
 None
 1.15A 1e7bA-3kd9A:
undetectable		 1e7bA-3kd9A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 3kd9 COENZYME A DISULFIDE
REDUCTASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 279
THR A 284
VAL A 295
ASN A 302
PRO A 299
 None
 1.18A 1sg9A-3kd9A:
3.0		 1sg9A-3kd9A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 3kd9 COENZYME A DISULFIDE
REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 THR A  37
GLY A 111
ASP A 280
ALA A  13
 None
 0.88A 1sg9A-3kd9A:
3.0		 1sg9A-3kd9A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 3kd9 COENZYME A DISULFIDE
REDUCTASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A 168
GLY A 171
ALA A 164
HIS A 203
PHE A 330
 None
 1.13A 1ve3A-3kd9A:
4.2		 1ve3A-3kd9A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 3kd9 COENZYME A DISULFIDE
REDUCTASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A 168
GLY A 171
ALA A 164
HIS A 203
PHE A 330
 None
 1.13A 1ve3B-3kd9A:
4.4		 1ve3B-3kd9A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3kd9 COENZYME A DISULFIDE
REDUCTASE
(Pyrococcus
horikoshii) 		6 / 12 ILE A   9
GLY A  10
GLY A  12
SER A  41
PHE A 108
ALA A  18
 None
 1.50A 1vq1B-3kd9A:
3.1		 1vq1B-3kd9A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3kd9 COENZYME A DISULFIDE
REDUCTASE
(Pyrococcus
horikoshii) 		4 / 8 THR A 264
GLY A 257
THR A 259
ALA A 261
 None
 0.84A 2a1hA-3kd9A:
undetectable
2a1hB-3kd9A:
undetectable		 2a1hA-3kd9A:
22.18
2a1hB-3kd9A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3kd9 COENZYME A DISULFIDE
REDUCTASE
(Pyrococcus
horikoshii) 		5 / 12 ASN A 311
ALA A 282
ILE A 262
ALA A  18
ILE A   8
 None
 0.91A 2h42B-3kd9A:
undetectable		 2h42B-3kd9A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3kd9 COENZYME A DISULFIDE
REDUCTASE
(Pyrococcus
horikoshii) 		4 / 6 LEU A 374
ALA A 402
LEU A 385
ALA A 415
 None
 0.97A 2vcvB-3kd9A:
undetectable		 2vcvB-3kd9A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 3kd9 COENZYME A DISULFIDE
REDUCTASE
(Pyrococcus
horikoshii) 		4 / 8 VAL A 192
LEU A 433
ARG A 398
ALA A 402
 None
 0.94A 2xfsA-3kd9A:
undetectable		 2xfsA-3kd9A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 3kd9 COENZYME A DISULFIDE
REDUCTASE
(Pyrococcus
horikoshii) 		4 / 8 VAL A 192
LEU A 433
ARG A 398
ALA A 402
 None
 0.95A 2xh9A-3kd9A:
undetectable		 2xh9A-3kd9A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 3kd9 COENZYME A DISULFIDE
REDUCTASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A 252
ASN A 245
GLY A  10
ILE A   8
VAL A  85
 None
 0.94A 3lzvA-3kd9A:
undetectable		 3lzvA-3kd9A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3kd9 COENZYME A DISULFIDE
REDUCTASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 156
ILE A 153
ILE A 177
ILE A 161
ARG A 186
 None
 0.98A 3uj6A-3kd9A:
3.3		 3uj6A-3kd9A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 3kd9 COENZYME A DISULFIDE
REDUCTASE
(Pyrococcus
horikoshii) 		4 / 7 GLY A 260
ALA A 261
ALA A 112
ASP A 280
 None
 0.76A 3ur0B-3kd9A:
undetectable		 3ur0B-3kd9A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3kd9 COENZYME A DISULFIDE
REDUCTASE
(Pyrococcus
horikoshii) 		5 / 8 LEU A 433
LEU A 374
VAL A 388
ILE A 399
MET A 405
 None
 1.41A 4oj4A-3kd9A:
undetectable		 4oj4A-3kd9A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 3kd9 COENZYME A DISULFIDE
REDUCTASE
(Pyrococcus
horikoshii) 		4 / 8 ALA A 278
GLY A 305
ALA A  18
GLY A  15
 None
 0.67A 4zjzA-3kd9A:
2.3		 4zjzA-3kd9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_B_FOLB201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 3kd9 COENZYME A DISULFIDE
REDUCTASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 106
ASN A 265
TYR A 105
ASN A 274
VAL A 272
 None
 1.49A 5d0yB-3kd9A:
0.0		 5d0yB-3kd9A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3kd9 COENZYME A DISULFIDE
REDUCTASE
(Pyrococcus
horikoshii) 		5 / 6 PHE A 330
VAL A 174
LEU A 206
LEU A 200
HIS A 203
 None
 1.40A 6e43A-3kd9A:
undetectable		 6e43A-3kd9A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3kd9 COENZYME A DISULFIDE
REDUCTASE
(Pyrococcus
horikoshii) 		5 / 6 PHE A 330
VAL A 174
LEU A 206
LEU A 200
HIS A 203
 None
 1.38A 6e43B-3kd9A:
undetectable		 6e43B-3kd9A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3kd9 COENZYME A DISULFIDE
REDUCTASE
(Pyrococcus
horikoshii) 		5 / 6 PHE A 330
VAL A 174
LEU A 206
LEU A 200
HIS A 203
 None
 1.42A 6e43C-3kd9A:
undetectable		 6e43C-3kd9A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3kd9 COENZYME A DISULFIDE
REDUCTASE
(Pyrococcus
horikoshii) 		5 / 6 PHE A 330
VAL A 174
LEU A 206
LEU A 200
HIS A 203
 None
 1.42A 6e43D-3kd9A:
undetectable		 6e43D-3kd9A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3kd9 COENZYME A DISULFIDE
REDUCTASE
(Pyrococcus
horikoshii) 		5 / 11 ALA A  18
ALA A 278
ALA A 308
GLY A  11
GLY A  10
 None
 0.88A 6hwdK-3kd9A:
undetectable
6hwdL-3kd9A:
undetectable		 6hwdK-3kd9A:
12.47
6hwdL-3kd9A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3kd9 COENZYME A DISULFIDE
REDUCTASE
(Pyrococcus
horikoshii) 		5 / 11 ALA A  18
ALA A 278
ALA A 308
GLY A  11
GLY A  10
 None
 0.88A 6hwdY-3kd9A:
undetectable
6hwdZ-3kd9A:
undetectable		 6hwdY-3kd9A:
12.47
6hwdZ-3kd9A:
9.13