SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kda'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 3kda CFTR INHIBITORY
FACTOR (CIF)
(Pseudomonas
aeruginosa) 		5 / 10 GLY D  90
ASN D 233
LEU D  46
VAL D  44
ASN D 134
 None
 1.22A 1fpqA-3kdaD:
3.1		 1fpqA-3kdaD:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 3kda CFTR INHIBITORY
FACTOR (CIF)
(Pseudomonas
aeruginosa) 		4 / 7 ASP D  87
TYR D  38
TYR D  48
PRO D  86
 None
 1.41A 2q6kA-3kdaD:
2.2		 2q6kA-3kdaD:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 3kda CFTR INHIBITORY
FACTOR (CIF)
(Pseudomonas
aeruginosa) 		4 / 5 PRO D 122
ILE D 146
ARG D 115
ASP D 145
 None
 1.46A 2rhmB-3kdaD:
2.6		 2rhmB-3kdaD:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 3kda CFTR INHIBITORY
FACTOR (CIF)
(Pseudomonas
aeruginosa) 		4 / 5 ARG D 256
ALA D 284
ASP D 286
GLU D 285
 None
 1.34A 2xrzA-3kdaD:
undetectable		 2xrzA-3kdaD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3kda CFTR INHIBITORY
FACTOR (CIF)
(Pseudomonas
aeruginosa) 		5 / 6 GLY D 271
GLY D 266
GLY D 267
GLY D 296
GLY D 294
 None
 0.93A 3bogB-3kdaD:
undetectable
3bogD-3kdaD:
undetectable		 3bogB-3kdaD:
undetectable
3bogD-3kdaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 3kda CFTR INHIBITORY
FACTOR (CIF)
(Pseudomonas
aeruginosa) 		5 / 12 PRO D 157
GLY D  64
LEU D 200
PHE D 203
HIS D 297
 None
 0.99A 3e23A-3kdaD:
2.2		 3e23A-3kdaD:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3kda CFTR INHIBITORY
FACTOR (CIF)
(Pseudomonas
aeruginosa) 		5 / 12 GLY D  92
ALA D  37
TYR D  38
LEU D 110
TYR D  48
 None
 1.14A 3qxyA-3kdaD:
undetectable		 3qxyA-3kdaD:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3kda CFTR INHIBITORY
FACTOR (CIF)
(Pseudomonas
aeruginosa) 		5 / 11 GLY D  92
ALA D  37
TYR D  38
LEU D 110
TYR D  48
 None
 1.18A 3rc0A-3kdaD:
undetectable		 3rc0A-3kdaD:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3kda CFTR INHIBITORY
FACTOR (CIF)
(Pseudomonas
aeruginosa) 		5 / 12 GLY D  92
ALA D  37
TYR D  38
LEU D 110
TYR D  48
 None
 1.19A 3rc0B-3kdaD:
undetectable		 3rc0B-3kdaD:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 3kda CFTR INHIBITORY
FACTOR (CIF)
(Pseudomonas
aeruginosa) 		5 / 11 PRO D  89
THR D  99
GLY D 100
PRO D  97
ASP D  42
 None
 1.15A 3t8nD-3kdaD:
undetectable
3t8nF-3kdaD:
undetectable		 3t8nD-3kdaD:
17.45
3t8nF-3kdaD:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 3kda CFTR INHIBITORY
FACTOR (CIF)
(Pseudomonas
aeruginosa) 		4 / 8 ASP D 129
PHE D 178
VAL D 175
HIS D 297
 None
 0.95A 4f5zA-3kdaD:
27.8		 4f5zA-3kdaD:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 3kda CFTR INHIBITORY
FACTOR (CIF)
(Pseudomonas
aeruginosa) 		5 / 12 ASP D 129
PHE D 181
TYR D 239
HIS D 297
TRP D 298
 None
 0.40A 4j03A-3kdaD:
30.8		 4j03A-3kdaD:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 3kda CFTR INHIBITORY
FACTOR (CIF)
(Pseudomonas
aeruginosa) 		5 / 12 ILE D 156
PHE D 181
TYR D 239
HIS D 297
TRP D 298
 None
 1.07A 4j03A-3kdaD:
30.8		 4j03A-3kdaD:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 3kda CFTR INHIBITORY
FACTOR (CIF)
(Pseudomonas
aeruginosa) 		4 / 7 LEU D 242
ASN D 134
GLN D 105
GLU D 104
 None
 1.04A 5tudA-3kdaD:
undetectable		 5tudA-3kdaD:
20.61