SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kds'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3kds CELL DIVISION
PROTEIN FTSH
(Thermotoga
maritima) 		5 / 12 GLY E 299
LEU E 180
PRO E 194
LEU E 173
VAL E 214
 None
 1.08A 1fduA-3kdsE:
undetectable		 1fduA-3kdsE:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3kds CELL DIVISION
PROTEIN FTSH
(Thermotoga
maritima) 		5 / 12 VAL E 265
GLY E 266
LEU E 316
GLY E 227
MET E 291
 None
 1.17A 1fduC-3kdsE:
undetectable		 1fduC-3kdsE:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 3kds CELL DIVISION
PROTEIN FTSH
(Thermotoga
maritima) 		5 / 12 GLY E 266
LEU E 284
LEU E 288
ALA E 304
PHE E 322
 None
 0.94A 1gseB-3kdsE:
undetectable		 1gseB-3kdsE:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3kds CELL DIVISION
PROTEIN FTSH
(Thermotoga
maritima) 		4 / 4 ALA E 484
VAL E 488
ALA E 485
HIS E 423
 None
None
None
ZN  E 996 ( 3.3A)
 1.10A 1q23A-3kdsE:
undetectable		 1q23A-3kdsE:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3kds CELL DIVISION
PROTEIN FTSH
(Thermotoga
maritima) 		4 / 4 ALA E 484
VAL E 488
ALA E 485
HIS E 423
 None
None
None
ZN  E 996 ( 3.3A)
 1.16A 1q23F-3kdsE:
undetectable		 1q23F-3kdsE:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3kds CELL DIVISION
PROTEIN FTSH
(Thermotoga
maritima) 		4 / 4 ALA E 484
VAL E 488
ALA E 485
HIS E 423
 None
None
None
ZN  E 996 ( 3.3A)
 1.03A 1q23K-3kdsE:
undetectable		 1q23K-3kdsE:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3kds CELL DIVISION
PROTEIN FTSH
(Thermotoga
maritima) 		4 / 8 ALA E 213
LEU E 210
GLY E 206
GLY E 164
 None
 0.87A 1rukH-3kdsE:
undetectable
1rukL-3kdsE:
undetectable		 1rukH-3kdsE:
17.58
1rukL-3kdsE:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 3kds CELL DIVISION
PROTEIN FTSH
(Thermotoga
maritima) 		3 / 3 ASP E 292
PHE E 246
ASN E 285
 None
 0.67A 1sg9B-3kdsE:
undetectable		 1sg9B-3kdsE:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 3kds CELL DIVISION
PROTEIN FTSH
(Thermotoga
maritima) 		5 / 12 ILE E 301
LEU E 210
VAL E 214
GLU E 175
LEU E 173
 None
 0.89A 2bxfA-3kdsE:
undetectable		 2bxfA-3kdsE:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 3kds CELL DIVISION
PROTEIN FTSH
(Thermotoga
maritima) 		5 / 12 ILE E 301
LEU E 210
VAL E 214
GLU E 175
LEU E 173
 None
 0.92A 2bxfB-3kdsE:
2.4		 2bxfB-3kdsE:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3kds CELL DIVISION
PROTEIN FTSH
(Thermotoga
maritima) 		4 / 7 PHE E 490
ALA E 421
ARG E 418
TYR E 422
 None
 1.25A 2e5dA-3kdsE:
undetectable
2e5dB-3kdsE:
undetectable		 2e5dA-3kdsE:
24.44
2e5dB-3kdsE:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 3kds CELL DIVISION
PROTEIN FTSH
(Thermotoga
maritima) 		5 / 12 GLY E 426
ALA E 425
ILE E 592
ILE E 600
ILE E 443
 None
 0.92A 2hs1A-3kdsE:
undetectable		 2hs1A-3kdsE:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 3kds CELL DIVISION
PROTEIN FTSH
(Thermotoga
maritima) 		5 / 12 ALA E 207
GLY E 201
GLY E 266
LEU E 312
LEU E 316
 None
 1.04A 2hw2A-3kdsE:
undetectable		 2hw2A-3kdsE:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 3kds CELL DIVISION
PROTEIN FTSH
(Thermotoga
maritima) 		5 / 12 LEU E 479
LEU E 480
GLY E 481
VAL E 434
THR E 456
 None
 1.45A 2q7lA-3kdsE:
2.1		 2q7lA-3kdsE:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3kds CELL DIVISION
PROTEIN FTSH
(Thermotoga
maritima) 		5 / 12 ILE E 256
ALA E 169
VAL E 328
PHE E 222
HIS E 224
 None
 1.42A 2qo4A-3kdsE:
undetectable		 2qo4A-3kdsE:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 3kds CELL DIVISION
PROTEIN FTSH
(Thermotoga
maritima) 		4 / 8 ILE E 256
LEU E 180
ARG E 212
GLY E 216
 None
 0.69A 2vdbA-3kdsE:
undetectable		 2vdbA-3kdsE:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 3kds CELL DIVISION
PROTEIN FTSH
(Thermotoga
maritima) 		4 / 6 ILE E 582
LYS E 589
ILE E 445
HIS E 423
 None
None
None
ZN  E 996 ( 3.3A)
 1.11A 3eteA-3kdsE:
undetectable
3eteE-3kdsE:
undetectable		 3eteA-3kdsE:
23.43
3eteE-3kdsE:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 3kds CELL DIVISION
PROTEIN FTSH
(Thermotoga
maritima) 		4 / 7 LYS E 589
ILE E 445
HIS E 423
ILE E 582
 None
None
ZN  E 996 ( 3.3A)
None
 1.13A 3eteD-3kdsE:
undetectable
3eteF-3kdsE:
undetectable		 3eteD-3kdsE:
23.43
3eteF-3kdsE:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 3kds CELL DIVISION
PROTEIN FTSH
(Thermotoga
maritima) 		3 / 3 HIS E 423
GLU E 424
HIS E 427
 ZN  E 996 ( 3.3A)
NHX  E 998 (-3.0A)
ZN  E 996 ( 3.3A)
 0.19A 3kecB-3kdsE:
undetectable		 3kecB-3kdsE:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 3kds CELL DIVISION
PROTEIN FTSH
(Thermotoga
maritima) 		4 / 6 ALA E 428
ILE E 582
LEU E 597
GLU E 424
 None
None
None
NHX  E 998 (-3.0A)
 0.83A 3r9sA-3kdsE:
undetectable		 3r9sA-3kdsE:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 3kds CELL DIVISION
PROTEIN FTSH
(Thermotoga
maritima) 		4 / 6 ALA E 428
ILE E 582
LEU E 597
GLU E 424
 None
None
None
NHX  E 998 (-3.0A)
 0.89A 3r9sC-3kdsE:
undetectable		 3r9sC-3kdsE:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3kds CELL DIVISION
PROTEIN FTSH
(Thermotoga
maritima) 		5 / 12 ILE E 326
PHE E 258
VAL E 302
ILE E 170
ALA E 169
 None
 1.10A 5n0wB-3kdsE:
3.2		 5n0wB-3kdsE:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 3kds CELL DIVISION
PROTEIN FTSH
(Thermotoga
maritima) 		5 / 10 ALA E 305
ILE E 301
ILE E 256
VAL E 214
ALA E 207
 None
 1.19A 5nukA-3kdsE:
undetectable		 5nukA-3kdsE:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 3kds CELL DIVISION
PROTEIN FTSH
(Thermotoga
maritima) 		5 / 12 ARG E 336
GLY E 165
GLY E 367
VAL E 366
THR E 205
 None
 1.33A 5o4yD-3kdsE:
undetectable
5o4yE-3kdsE:
undetectable		 5o4yD-3kdsE:
5.56
5o4yE-3kdsE:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3kds CELL DIVISION
PROTEIN FTSH
(Thermotoga
maritima) 		5 / 11 LEU E 480
GLY E 482
GLU E 424
GLY E 426
LEU E 476
 None
ZN  E 996 ( 4.6A)
NHX  E 998 (-3.0A)
None
None
 0.92A 5o96G-3kdsE:
undetectable		 5o96G-3kdsE:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3kds CELL DIVISION
PROTEIN FTSH
(Thermotoga
maritima) 		5 / 12 ILE E 262
GLY E 227
LEU E 245
VAL E 257
LEU E 233
 None
 1.03A 5ycnA-3kdsE:
1.5		 5ycnA-3kdsE:
20.93