SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ke3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE
(Psychrobacter
arcticus) 		4 / 7 VAL A  35
LEU A  39
TYR A 241
LEU A  25
 None
 0.89A 1pthA-3ke3A:
undetectable		 1pthA-3ke3A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE
(Psychrobacter
arcticus) 		4 / 7 VAL A  35
LEU A  39
TYR A 241
LEU A  25
 None
 0.89A 1pthB-3ke3A:
undetectable		 1pthB-3ke3A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE
(Psychrobacter
arcticus) 		5 / 12 GLY A 178
GLY A 199
GLY A 354
SER A 177
HIS A 142
 None
LLP  A 198 ( 2.4A)
LLP  A 198 ( 4.8A)
None
None
 1.24A 1wg8A-3ke3A:
2.9		 1wg8A-3ke3A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE
(Psychrobacter
arcticus) 		5 / 11 ALA A 332
PHE A 368
PHE A 324
THR A 313
ILE A 295
 None
 1.22A 2w3aA-3ke3A:
undetectable		 2w3aA-3ke3A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE
(Psychrobacter
arcticus) 		5 / 12 MET A 252
VAL A  53
TYR A 248
VAL A 191
MET A 210
 None
 1.20A 3dl9A-3ke3A:
undetectable		 3dl9A-3ke3A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE
(Psychrobacter
arcticus) 		5 / 11 LEU A  70
ALA A 214
GLY A 188
ILE A 189
ILE A 137
 None
 0.99A 3ebzA-3ke3A:
undetectable		 3ebzA-3ke3A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE
(Psychrobacter
arcticus) 		5 / 10 ALA A 158
GLU A 154
ALA A 140
ILE A 172
LEU A 182
 None
 1.19A 3fl9F-3ke3A:
undetectable		 3fl9F-3ke3A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE
(Psychrobacter
arcticus) 		3 / 3 SER A  58
GLY A  59
THR A  60
 LLP  A 198 ( 2.9A)
LLP  A 198 ( 3.6A)
LLP  A 198 ( 3.6A)
 0.21A 3k9wA-3ke3A:
undetectable		 3k9wA-3ke3A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA279_0
(UNIVERSAL STRESS
PROTEIN)		 3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE
(Psychrobacter
arcticus) 		4 / 4 SER A  85
SER A 147
THR A 145
SER A 146
 None
None
LLP  A 198 (-3.0A)
None
 1.39A 3loqA-3ke3A:
2.7		 3loqA-3ke3A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE
(Psychrobacter
arcticus) 		5 / 12 GLU A 304
GLY A 148
ALA A 299
ALA A 176
VAL A 308
 None
None
None
LLP  A 198 ( 3.3A)
None
 1.07A 3nvkF-3ke3A:
undetectable
3nvkJ-3ke3A:
2.6		 3nvkF-3ke3A:
23.23
3nvkJ-3ke3A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE
(Psychrobacter
arcticus) 		4 / 7 ARG A 239
ALA A  51
VAL A  53
LEU A 211
 ACT  A 383 (-3.5A)
ACT  A 383 ( 3.7A)
None
None
 0.79A 3o14A-3ke3A:
undetectable		 3o14A-3ke3A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE
(Psychrobacter
arcticus) 		5 / 12 ALA A 206
GLY A  62
ILE A 193
LEU A 211
VAL A  53
 None
 1.02A 3o7wA-3ke3A:
3.2		 3o7wA-3ke3A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_C_SAMC1263_0
(POLYPROTEIN)		 3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE
(Psychrobacter
arcticus) 		5 / 12 SER A 201
GLY A 199
GLY A 354
GLU A 266
ILE A 274
 LLP  A 198 ( 4.3A)
LLP  A 198 ( 2.4A)
LLP  A 198 ( 4.8A)
None
None
 0.85A 4ctkC-3ke3A:
2.4		 4ctkC-3ke3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE
(Psychrobacter
arcticus) 		5 / 9 VAL A 298
ALA A 299
GLY A 334
SER A 146
GLY A 148
 None
 1.24A 4mmfB-3ke3A:
undetectable		 4mmfB-3ke3A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE
(Psychrobacter
arcticus) 		4 / 7 SER A  85
ARG A 349
SER A 146
GLU A 144
 None
ACT  A 380 (-3.1A)
None
None
 1.20A 4xzkA-3ke3A:
undetectable		 4xzkA-3ke3A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE
(Psychrobacter
arcticus) 		5 / 12 ILE A 295
PHE A 348
LEU A 282
LEU A 290
PHE A 368
 None
 1.12A 5xxiA-3ke3A:
undetectable		 5xxiA-3ke3A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE
(Psychrobacter
arcticus) 		4 / 8 HIS A 319
PHE A 324
SER A 311
LEU A 372
 ACT  A 382 (-4.5A)
None
None
None
 1.09A 5y2tB-3ke3A:
undetectable		 5y2tB-3ke3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE
(Psychrobacter
arcticus) 		5 / 12 ILE A 193
ILE A  55
VAL A  53
ALA A 215
LEU A 211
 None
 1.16A 6ajiA-3ke3A:
undetectable		 6ajiA-3ke3A:
18.99