SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kea'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 3kea K1L
(Vaccinia
virus) 		5 / 9 SER A 131
THR A 130
GLY A  94
ASP A  91
ASP A  92
 None
 1.45A 3sfuA-3keaA:
undetectable		 3sfuA-3keaA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 3kea K1L
(Vaccinia
virus) 		3 / 3 TYR A 246
MET A 209
LEU A 180
 None
 0.96A 3vw1D-3keaA:
undetectable		 3vw1D-3keaA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 3kea K1L
(Vaccinia
virus) 		4 / 7 THR A 252
HIS A 243
ASN A 261
TYR A 221
 None
 1.46A 4a3uA-3keaA:
undetectable		 4a3uA-3keaA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 3kea K1L
(Vaccinia
virus) 		4 / 7 THR A 252
HIS A 243
ASN A 261
TYR A 221
 None
 1.42A 4a3uB-3keaA:
undetectable		 4a3uB-3keaA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3kea K1L
(Vaccinia
virus) 		4 / 7 LYS A 247
ASP A 264
ILE A 267
TYR A 277
 None
 1.35A 5a06B-3keaA:
undetectable		 5a06B-3keaA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 3kea K1L
(Vaccinia
virus) 		6 / 12 VAL A 136
PHE A 132
ILE A 159
ILE A 164
LEU A 157
VAL A 144
 None
 1.21A 5uvmB-3keaA:
undetectable		 5uvmB-3keaA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 3kea K1L
(Vaccinia
virus) 		3 / 3 TYR A  36
HIS A  29
MET A   1
 None
 1.14A 6af6A-3keaA:
undetectable		 6af6A-3keaA:
22.41