SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3keb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MSK_A_SAMA1301_0
(COBALAMIN-DEPENDENT
METHIONINE SYNTHASE)		 3keb PROBABLE THIOL
PEROXIDASE
(Chromobacterium
violaceum) 		5 / 10 ASP A 116
ARG A 120
PRO A 136
ALA A 137
ALA A  63
 None
 1.46A 1mskA-3kebA:
undetectable		 1mskA-3kebA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 3keb PROBABLE THIOL
PEROXIDASE
(Chromobacterium
violaceum) 		5 / 11 LEU A 108
ALA A  97
LEU A  94
SER A  93
THR A  87
 None
 1.27A 1tz8A-3kebA:
undetectable
1tz8B-3kebA:
undetectable		 1tz8A-3kebA:
20.81
1tz8B-3kebA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3keb PROBABLE THIOL
PEROXIDASE
(Chromobacterium
violaceum) 		6 / 12 ALA A 141
LEU A  41
SER A  28
THR A  53
ILE A  86
ARG A 120
 None
 1.45A 2oipA-3kebA:
undetectable		 2oipA-3kebA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3keb PROBABLE THIOL
PEROXIDASE
(Chromobacterium
violaceum) 		6 / 12 ALA A 141
LEU A  41
SER A  28
THR A  53
ILE A  86
ARG A 120
 None
 1.44A 2oipD-3kebA:
undetectable		 2oipD-3kebA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 3keb PROBABLE THIOL
PEROXIDASE
(Chromobacterium
violaceum) 		4 / 7 PRO A 136
GLY A  64
LEU A 130
THR A 156
 None
 0.81A 2vl2B-3kebA:
17.2		 2vl2B-3kebA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3keb PROBABLE THIOL
PEROXIDASE
(Chromobacterium
violaceum) 		6 / 12 ALA A 141
LEU A  41
SER A  28
THR A  53
ILE A  86
ARG A 120
 None
 1.45A 3hj3A-3kebA:
undetectable		 3hj3A-3kebA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3keb PROBABLE THIOL
PEROXIDASE
(Chromobacterium
violaceum) 		6 / 12 ALA A 141
LEU A  41
SER A  28
THR A  53
ILE A  86
ARG A 120
 None
 1.49A 3hj3B-3kebA:
undetectable		 3hj3B-3kebA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3keb PROBABLE THIOL
PEROXIDASE
(Chromobacterium
violaceum) 		4 / 5 VAL A  32
SER A 110
GLY A 114
ARG A 115
 None
 1.29A 3v4tA-3kebA:
undetectable
3v4tD-3kebA:
undetectable		 3v4tA-3kebA:
20.95
3v4tD-3kebA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 3keb PROBABLE THIOL
PEROXIDASE
(Chromobacterium
violaceum) 		4 / 8 ASN A 145
ALA A 141
LEU A  41
TYR A 121
 None
 1.22A 4ijiF-3kebA:
undetectable		 4ijiF-3kebA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3keb PROBABLE THIOL
PEROXIDASE
(Chromobacterium
violaceum) 		3 / 3 THR A 111
HIS A  62
LEU A 130
 None
 0.76A 5axdA-3kebA:
2.3		 5axdA-3kebA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 3keb PROBABLE THIOL
PEROXIDASE
(Chromobacterium
violaceum) 		4 / 6 ASP A  58
PRO A 136
TYR A 133
LEU A 130
 None
 1.09A 5bmvB-3kebA:
undetectable		 5bmvB-3kebA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 3keb PROBABLE THIOL
PEROXIDASE
(Chromobacterium
violaceum) 		4 / 6 LEU A  68
LEU A  94
THR A  53
ARG A 113
 None
 1.03A 6ew0G-3kebA:
undetectable		 6ew0G-3kebA:
16.89