SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3keq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZUL_A_SAMA376_0 (PROBABLE RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE)	3keq	REDOX-SENSING TRANSCRIPTIONAL REPRESSOR REX (Streptococcus agalactiae)	5 / 12	GLY A 91 GLY A 93 ALA A 98 LEU A 99 VAL A 164	NAD A 213 (-3.6A) NAD A 213 (-3.2A) None None NAD A 213 (-4.8A)	1.06A	2zulA-3keqA: 5.1	2zulA-3keqA: 19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DMH_A_SAMA384_0 (PROBABLE RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE)	3keq	REDOX-SENSING TRANSCRIPTIONAL REPRESSOR REX (Streptococcus agalactiae)	5 / 12	GLY A 91 GLY A 93 ALA A 98 LEU A 99 VAL A 164	NAD A 213 (-3.6A) NAD A 213 (-3.2A) None None NAD A 213 (-4.8A)	1.01A	3dmhA-3keqA: 4.8	3dmhA-3keqA: 19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FRQ_A_ERYA195_0 (REPRESSOR PROTEIN MPHR(A))	3keq	REDOX-SENSING TRANSCRIPTIONAL REPRESSOR REX (Streptococcus agalactiae)	5 / 12	VAL A 156 LEU A 168 SER A 120 VAL A 90 ILE A 140	NAD A 213 (-4.0A) None None None None	1.37A	3frqA-3keqA: 3.6	3frqA-3keqA: 21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q87_B_SAMB300_0 (N6 ADENINE SPECIFIC DNA METHYLASE)	3keq	REDOX-SENSING TRANSCRIPTIONAL REPRESSOR REX (Streptococcus agalactiae)	5 / 12	GLY A 91 ASP A 117 LEU A 118 ASN A 121 PRO A 157	NAD A 213 (-3.6A) NAD A 213 (-2.8A) NAD A 213 (-4.4A) NAD A 213 ( 4.7A) NAD A 213 (-4.0A)	1.15A	3q87B-3keqA: 5.1	3q87B-3keqA: 20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z69_I_DIFI1006_1 (SERUM ALBUMIN)	3keq	REDOX-SENSING TRANSCRIPTIONAL REPRESSOR REX (Streptococcus agalactiae)	5 / 10	ARG A 14 PHE A 56 LEU A 79 ILE A 78 ALA A 12	None	1.11A	4z69I-3keqA: undetectable	4z69I-3keqA: 16.47

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2ZUL_A_SAMA376_0","PROBABLE RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE","3keq","REDOX-SENSING TRANSCRIPTIONAL REPRESSOR REX","Streptococcus agalactiae",5,"GLY A  91;GLY A  93;ALA A  98;LEU A  99;VAL A 164","NAD A 213 (-3.6A);NAD A 213 (-3.2A);None;None;NAD A 213 (-4.8A)","1.06A","2zulA-3keqA:5.1","2zulA-3keqA:19.00"],["3DMH_A_SAMA384_0","PROBABLE RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE","3keq","REDOX-SENSING TRANSCRIPTIONAL REPRESSOR REX","Streptococcus agalactiae",5,"GLY A  91;GLY A  93;ALA A  98;LEU A  99;VAL A 164","NAD A 213 (-3.6A);NAD A 213 (-3.2A);None;None;NAD A 213 (-4.8A)","1.01A","3dmhA-3keqA:4.8","3dmhA-3keqA:19.00"],["3FRQ_A_ERYA195_0","REPRESSOR PROTEIN MPHR(A)","3keq","REDOX-SENSING TRANSCRIPTIONAL REPRESSOR REX","Streptococcus agalactiae",5,"VAL A 156;LEU A 168;SER A 120;VAL A  90;ILE A 140","NAD A 213 (-4.0A);None;None;None;None","1.37A","3frqA-3keqA:3.6","3frqA-3keqA:21.82"],["3Q87_B_SAMB300_0","N6 ADENINE SPECIFIC DNA METHYLASE","3keq","REDOX-SENSING TRANSCRIPTIONAL REPRESSOR REX","Streptococcus agalactiae",5,"GLY A  91;ASP A 117;LEU A 118;ASN A 121;PRO A 157","NAD A 213 (-3.6A);NAD A 213 (-2.8A);NAD A 213 (-4.4A);NAD A 213 ( 4.7A);NAD A 213 (-4.0A)","1.15A","3q87B-3keqA:5.1","3q87B-3keqA:20.30"],["4Z69_I_DIFI1006_1","SERUM ALBUMIN","3keq","REDOX-SENSING TRANSCRIPTIONAL REPRESSOR REX","Streptococcus agalactiae",5,"ARG A  14;PHE A  56;LEU A  79;ILE A  78;ALA A  12","None","1.11A","4z69I-3keqA:undetectable","4z69I-3keqA:16.47"]]