SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kev'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N13_B_AG2B7011_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN)	3kev	GALIERIA SULFURARIA DCUN1 DOMAIN-CONTAINING PROTEIN (Galdieria sulphuraria)	4 / 5	ARG A 98 LEU A 164 ASP A 160 LEU A 157	None	1.21A	1n13B-3kevA: undetectable 1n13C-3kevA: undetectable	1n13B-3kevA: 19.79 1n13C-3kevA: 14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PXX_A_DIFA701_1 (PROSTAGLANDIN G/H SYNTHASE 2)	3kev	GALIERIA SULFURARIA DCUN1 DOMAIN-CONTAINING PROTEIN (Galdieria sulphuraria)	5 / 10	LEU A 12 LEU A 52 VAL A 66 GLY A 68 ALA A 70	None None ACT A 202 ( 4.4A) None None	1.13A	1pxxA-3kevA: undetectable	1pxxA-3kevA: 15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PXX_B_DIFB1701_1 (PROSTAGLANDIN G/H SYNTHASE 2)	3kev	GALIERIA SULFURARIA DCUN1 DOMAIN-CONTAINING PROTEIN (Galdieria sulphuraria)	5 / 9	LEU A 12 LEU A 52 VAL A 66 GLY A 68 ALA A 70	None None ACT A 202 ( 4.4A) None None	1.14A	1pxxB-3kevA: undetectable	1pxxB-3kevA: 15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PXX_D_DIFD3701_1 (PROSTAGLANDIN G/H SYNTHASE 2)	3kev	GALIERIA SULFURARIA DCUN1 DOMAIN-CONTAINING PROTEIN (Galdieria sulphuraria)	5 / 10	LEU A 12 LEU A 52 VAL A 66 GLY A 68 ALA A 70	None None ACT A 202 ( 4.4A) None None	1.13A	1pxxD-3kevA: undetectable	1pxxD-3kevA: 15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BRF_A_SORA2_0 (LIN-12 AND GLP-1 PHENOTYPE PROTEIN 1, ISOFORM A)	3kev	GALIERIA SULFURARIA DCUN1 DOMAIN-CONTAINING PROTEIN (Galdieria sulphuraria)	3 / 3	LYS A 6 LYS A 63 VAL A 66	ACT A 202 (-2.6A) None ACT A 202 ( 4.4A)	0.81A	3brfA-3kevA: undetectable	3brfA-3kevA: 17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6B0C_D_TA1D502_1 (TUBULIN BETA CHAIN)	3kev	GALIERIA SULFURARIA DCUN1 DOMAIN-CONTAINING PROTEIN (Galdieria sulphuraria)	5 / 12	LEU A 84 LEU A 48 THR A 45 GLY A 28 LEU A 29	None None None None CSO A 58 ( 4.2A)	0.94A	6b0cD-3kevA: undetectable	6b0cD-3kevA: 17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	7DFR_A_FOLA161_1 (DIHYDROFOLATE REDUCTASE)	3kev	GALIERIA SULFURARIA DCUN1 DOMAIN-CONTAINING PROTEIN (Galdieria sulphuraria)	3 / 3	ASP A 153 LEU A 157 ARG A 98	None	0.87A	7dfrA-3kevA: undetectable	7dfrA-3kevA: 21.36

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1N13_B_AG2B7011_1","PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN;PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN","3kev","GALIERIA SULFURARIA DCUN1 DOMAIN-CONTAINING PROTEIN","Galdieria sulphuraria",4,"ARG A  98;LEU A 164;ASP A 160;LEU A 157","None","1.21A","1n13B-3kevA:undetectable;1n13C-3kevA:undetectable","1n13B-3kevA:19.79;1n13C-3kevA:14.07"],["1PXX_A_DIFA701_1","PROSTAGLANDIN G\/H SYNTHASE 2","3kev","GALIERIA SULFURARIA DCUN1 DOMAIN-CONTAINING PROTEIN","Galdieria sulphuraria",5,"LEU A  12;LEU A  52;VAL A  66;GLY A  68;ALA A  70","None;None;ACT A 202 ( 4.4A);None;None","1.13A","1pxxA-3kevA:undetectable","1pxxA-3kevA:15.49"],["1PXX_B_DIFB1701_1","PROSTAGLANDIN G\/H SYNTHASE 2","3kev","GALIERIA SULFURARIA DCUN1 DOMAIN-CONTAINING PROTEIN","Galdieria sulphuraria",5,"LEU A  12;LEU A  52;VAL A  66;GLY A  68;ALA A  70","None;None;ACT A 202 ( 4.4A);None;None","1.14A","1pxxB-3kevA:undetectable","1pxxB-3kevA:15.49"],["1PXX_D_DIFD3701_1","PROSTAGLANDIN G\/H SYNTHASE 2","3kev","GALIERIA SULFURARIA DCUN1 DOMAIN-CONTAINING PROTEIN","Galdieria sulphuraria",5,"LEU A  12;LEU A  52;VAL A  66;GLY A  68;ALA A  70","None;None;ACT A 202 ( 4.4A);None;None","1.13A","1pxxD-3kevA:undetectable","1pxxD-3kevA:15.49"],["3BRF_A_SORA2_0","LIN-12 AND GLP-1 PHENOTYPE PROTEIN 1, ISOFORM A","3kev","GALIERIA SULFURARIA DCUN1 DOMAIN-CONTAINING PROTEIN","Galdieria sulphuraria",3,"LYS A   6;LYS A  63;VAL A  66","ACT A 202 (-2.6A);None;ACT A 202 ( 4.4A)","0.81A","3brfA-3kevA:undetectable","3brfA-3kevA:17.15"],["6B0C_D_TA1D502_1","TUBULIN BETA CHAIN","3kev","GALIERIA SULFURARIA DCUN1 DOMAIN-CONTAINING PROTEIN","Galdieria sulphuraria",5,"LEU A  84;LEU A  48;THR A  45;GLY A  28;LEU A  29","None;None;None;None;CSO A  58 ( 4.2A)","0.94A","6b0cD-3kevA:undetectable","6b0cD-3kevA:17.01"],["7DFR_A_FOLA161_1","DIHYDROFOLATE REDUCTASE","3kev","GALIERIA SULFURARIA DCUN1 DOMAIN-CONTAINING PROTEIN","Galdieria sulphuraria",3,"ASP A 153;LEU A 157;ARG A  98","None","0.87A","7dfrA-3kevA:undetectable","7dfrA-3kevA:21.36"]]