SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kew'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 3kew DHHA1 DOMAIN PROTEIN
(Clostridium
perfringens) 		6 / 12 ILE A 185
LEU A 204
GLY A 187
THR A 201
LEU A  97
ASP A 108
 None
 1.42A 1liiA-3kewA:
undetectable		 1liiA-3kewA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 3kew DHHA1 DOMAIN PROTEIN
(Clostridium
perfringens) 		4 / 6 ALA A 144
ILE A 148
LEU A 101
GLU A 141
 None
 0.90A 3r9sA-3kewA:
undetectable		 3r9sA-3kewA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 3kew DHHA1 DOMAIN PROTEIN
(Clostridium
perfringens) 		3 / 3 GLU A  20
TYR A  60
GLU A  62
 None
 0.60A 4ryaA-3kewA:
undetectable		 4ryaA-3kewA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3kew DHHA1 DOMAIN PROTEIN
(Clostridium
perfringens) 		3 / 3 ARG A 211
THR A 219
TRP A 212
 None
 1.28A 4ug5A-3kewA:
undetectable		 4ug5A-3kewA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 3kew DHHA1 DOMAIN PROTEIN
(Clostridium
perfringens) 		3 / 3 ARG A  89
ASP A  47
TYR A   5
 None
 0.90A 4yo9B-3kewA:
2.5		 4yo9B-3kewA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 3kew DHHA1 DOMAIN PROTEIN
(Clostridium
perfringens) 		4 / 6 TYR A 157
LYS A 155
GLY A 187
LEU A 190
 None
 1.15A 5bphA-3kewA:
undetectable		 5bphA-3kewA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 3kew DHHA1 DOMAIN PROTEIN
(Clostridium
perfringens) 		4 / 7 TYR A 157
LYS A 155
GLY A 187
LEU A 190
 None
 1.13A 5bphB-3kewA:
undetectable		 5bphB-3kewA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 3kew DHHA1 DOMAIN PROTEIN
(Clostridium
perfringens) 		4 / 6 TYR A 157
LYS A 155
GLY A 187
LEU A 190
 None
 1.20A 5bphD-3kewA:
undetectable		 5bphD-3kewA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3kew DHHA1 DOMAIN PROTEIN
(Clostridium
perfringens) 		3 / 3 ASP A 127
ASN A 113
PHE A 110
 None
 0.71A 5dsgB-3kewA:
undetectable		 5dsgB-3kewA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3kew DHHA1 DOMAIN PROTEIN
(Clostridium
perfringens) 		3 / 3 ARG A 211
THR A 219
TRP A 212
 None
 1.23A 5g6cA-3kewA:
undetectable		 5g6cA-3kewA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3kew DHHA1 DOMAIN PROTEIN
(Clostridium
perfringens) 		5 / 12 ILE A  11
LEU A  80
LEU A   1
THR A   2
LEU A   4
 None
 0.84A 5xxiA-3kewA:
undetectable		 5xxiA-3kewA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 3kew DHHA1 DOMAIN PROTEIN
(Clostridium
perfringens) 		3 / 3 PHE A  38
ARG A  89
GLN A  44
 None
 0.83A 6g1pB-3kewA:
undetectable		 6g1pB-3kewA:
22.04