SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kez'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 3kez PUTATIVE SUGAR
BINDING PROTEIN
(Bacteroides
vulgatus) 		5 / 9 MET A 239
ALA A 368
GLU A 367
ARG A 425
ILE A 195
 None
 1.32A 1ereA-3kezA:
undetectable		 1ereA-3kezA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 3kez PUTATIVE SUGAR
BINDING PROTEIN
(Bacteroides
vulgatus) 		5 / 9 MET A 239
ALA A 368
GLU A 367
ARG A 425
ILE A 195
 None
 1.33A 1ereB-3kezA:
undetectable		 1ereB-3kezA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 3kez PUTATIVE SUGAR
BINDING PROTEIN
(Bacteroides
vulgatus) 		5 / 9 MET A 239
ALA A 368
GLU A 367
ARG A 425
ILE A 195
 None
 1.32A 1ereC-3kezA:
undetectable		 1ereC-3kezA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 3kez PUTATIVE SUGAR
BINDING PROTEIN
(Bacteroides
vulgatus) 		5 / 9 MET A 239
ALA A 368
GLU A 367
ARG A 425
ILE A 195
 None
 1.33A 1ereD-3kezA:
undetectable		 1ereD-3kezA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 3kez PUTATIVE SUGAR
BINDING PROTEIN
(Bacteroides
vulgatus) 		5 / 12 GLU A 416
ILE A 276
GLN A 343
ALA A 351
ARG A 357
 None
None
CA  A 501 (-3.6A)
None
None
 1.42A 1ki7A-3kezA:
undetectable		 1ki7A-3kezA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 3kez PUTATIVE SUGAR
BINDING PROTEIN
(Bacteroides
vulgatus) 		4 / 6 LEU A 160
THR A 192
TYR A 191
TYR A 233
 None
 1.43A 1qvuA-3kezA:
undetectable		 1qvuA-3kezA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 3kez PUTATIVE SUGAR
BINDING PROTEIN
(Bacteroides
vulgatus) 		5 / 12 LEU A 117
LEU A  48
ILE A  51
ILE A 143
ALA A 142
 None
 0.97A 2bxqA-3kezA:
undetectable		 2bxqA-3kezA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDK_A_C2FA1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 3kez PUTATIVE SUGAR
BINDING PROTEIN
(Bacteroides
vulgatus) 		5 / 11 LEU A 106
HIS A 102
SER A  58
TYR A  61
MET A 146
 None
 1.29A 2idkA-3kezA:
undetectable
2idkB-3kezA:
undetectable
2idkC-3kezA:
undetectable
2idkD-3kezA:
undetectable		 2idkA-3kezA:
20.83
2idkB-3kezA:
20.83
2idkC-3kezA:
20.83
2idkD-3kezA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 3kez PUTATIVE SUGAR
BINDING PROTEIN
(Bacteroides
vulgatus) 		5 / 11 ASN A 477
LEU A 460
CYH A 190
ILE A 171
ILE A 463
 EDO  A   4 (-4.0A)
None
None
None
None
 1.02A 2uxoB-3kezA:
undetectable		 2uxoB-3kezA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_L_CSCL1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 3kez PUTATIVE SUGAR
BINDING PROTEIN
(Bacteroides
vulgatus) 		5 / 12 TYR A  68
ARG A 225
TYR A 229
PHE A  93
HIS A 102
 None
 1.49A 2vavL-3kezA:
0.0		 2vavL-3kezA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3kez PUTATIVE SUGAR
BINDING PROTEIN
(Bacteroides
vulgatus) 		5 / 9 TYR A  52
LEU A 205
LEU A 198
ALA A 218
LEU A 222
 None
 1.28A 2vcvE-3kezA:
1.3		 2vcvE-3kezA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3kez PUTATIVE SUGAR
BINDING PROTEIN
(Bacteroides
vulgatus) 		3 / 3 TYR A 107
GLU A 467
ASN A 473
 EDO  A  14 (-3.7A)
EDO  A  14 (-3.2A)
None
 0.91A 2y7hC-3kezA:
undetectable		 2y7hC-3kezA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 3kez PUTATIVE SUGAR
BINDING PROTEIN
(Bacteroides
vulgatus) 		3 / 3 LYS A 339
ARG A 357
ASP A 321
 None
 1.27A 3o7wA-3kezA:
undetectable		 3o7wA-3kezA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3kez PUTATIVE SUGAR
BINDING PROTEIN
(Bacteroides
vulgatus) 		5 / 12 HIS A 418
GLY A 417
VAL A 423
ASP A 422
ALA A 361
 None
 1.10A 3sueC-3kezA:
undetectable		 3sueC-3kezA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 3kez PUTATIVE SUGAR
BINDING PROTEIN
(Bacteroides
vulgatus) 		4 / 5 SER A  58
ARG A  64
TYR A  88
VAL A  66
 None
EDO  A   8 (-3.3A)
None
None
 1.33A 3sufC-3kezA:
undetectable		 3sufC-3kezA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 3kez PUTATIVE SUGAR
BINDING PROTEIN
(Bacteroides
vulgatus) 		4 / 8 GLY A 294
ASN A 297
PRO A 288
ILE A 353
 None
 0.97A 4j4vC-3kezA:
undetectable		 4j4vC-3kezA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 3kez PUTATIVE SUGAR
BINDING PROTEIN
(Bacteroides
vulgatus) 		5 / 10 LEU A 141
LEU A 204
ASN A 134
LEU A  41
LEU A 123
 None
 1.12A 4po0A-3kezA:
undetectable		 4po0A-3kezA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 3kez PUTATIVE SUGAR
BINDING PROTEIN
(Bacteroides
vulgatus) 		5 / 12 LEU A 228
LEU A 406
ILE A 385
LEU A 382
LEU A 413
 None
 1.24A 5toaB-3kezA:
undetectable		 5toaB-3kezA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 3kez PUTATIVE SUGAR
BINDING PROTEIN
(Bacteroides
vulgatus) 		4 / 7 VAL A  66
ARG A 357
GLU A 416
ARG A 225
 None
 0.80A 5umwB-3kezA:
undetectable
5umwE-3kezA:
undetectable		 5umwB-3kezA:
10.24
5umwE-3kezA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 3kez PUTATIVE SUGAR
BINDING PROTEIN
(Bacteroides
vulgatus) 		4 / 7 ARG A 357
LEU A 327
TYR A 260
VAL A 337
 None
 1.02A 6g2pA-3kezA:
undetectable		 6g2pA-3kezA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		 3kez PUTATIVE SUGAR
BINDING PROTEIN
(Bacteroides
vulgatus) 		5 / 10 GLY A 145
LEU A 148
TYR A 107
SER A 101
VAL A 226
 None
None
EDO  A  14 (-3.7A)
EDO  A   8 ( 4.8A)
None
 1.21A 6gnfC-3kezA:
undetectable		 6gnfC-3kezA:
22.97