SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kf3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		5 / 12 ASP A 287
GLY A 289
ASP A 291
ILE A 485
PRO A 355
 None
None
None
None
NAG  A5001 ( 4.9A)
 0.89A 1hsgB-3kf3A:
undetectable		 1hsgB-3kf3A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 8 GLY A  83
ASP A 179
THR A 140
ASP A  50
 None
FRU  A 600 (-2.5A)
None
FRU  A 600 (-2.8A)
 0.89A 1m4iA-3kf3A:
undetectable		 1m4iA-3kf3A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		5 / 12 PHE A 292
ALA A 309
LEU A 308
PHE A 393
ILE A 485
 None
 1.27A 1mx8A-3kf3A:
undetectable		 1mx8A-3kf3A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 4 HIS A 118
VAL A 116
THR A  59
LEU A  62
 None
 1.21A 1oq5A-3kf3A:
undetectable		 1oq5A-3kf3A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 8 LEU A 357
THR A 388
ILE A 480
TYR A 478
 None
None
None
NAG  A5001 (-3.6A)
 0.82A 1qvtA-3kf3A:
undetectable		 1qvtA-3kf3A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 8 PHE A 153
SER A 154
LEU A 155
THR A 162
 None
 0.87A 1sbrA-3kf3A:
undetectable		 1sbrA-3kf3A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		5 / 12 ASP A 287
GLY A 289
ASP A 291
ILE A 485
PRO A 355
 None
None
None
None
NAG  A5001 ( 4.9A)
 1.03A 1sduB-3kf3A:
undetectable		 1sduB-3kf3A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		5 / 12 ASP A 287
GLY A 289
ASP A 291
ILE A 485
PRO A 355
 None
None
None
None
NAG  A5001 ( 4.9A)
 1.00A 2avsB-3kf3A:
undetectable		 2avsB-3kf3A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		5 / 12 ASP A 287
GLY A 289
ASP A 291
ILE A 485
PRO A 355
 None
None
None
None
NAG  A5001 ( 4.9A)
 0.93A 2b7zB-3kf3A:
undetectable		 2b7zB-3kf3A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 7 PHE A 502
ARG A 442
ALA A 317
TYR A 316
 None
 1.06A 2e5dA-3kf3A:
undetectable
2e5dB-3kf3A:
undetectable		 2e5dA-3kf3A:
21.95
2e5dB-3kf3A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 7 TYR A 316
PHE A 502
ARG A 442
ALA A 317
 None
 1.08A 2e5dA-3kf3A:
undetectable
2e5dB-3kf3A:
undetectable		 2e5dA-3kf3A:
21.95
2e5dB-3kf3A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		5 / 12 VAL A 447
PHE A 391
ILE A 415
ILE A 427
PHE A 501
 None
 1.24A 2ft9A-3kf3A:
undetectable		 2ft9A-3kf3A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 5 ILE A 429
PHE A 411
PHE A 431
ILE A 395
 None
 0.98A 2hjhA-3kf3A:
undetectable		 2hjhA-3kf3A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		5 / 12 ASP A 287
GLY A 289
ASP A 291
ILE A 485
PRO A 355
 None
None
None
None
NAG  A5001 ( 4.9A)
 0.96A 2hs1A-3kf3A:
undetectable		 2hs1A-3kf3A:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		5 / 12 ASP A 287
GLY A 289
ASP A 291
ILE A 485
PRO A 355
 None
None
None
None
NAG  A5001 ( 4.9A)
 0.91A 2nnkB-3kf3A:
undetectable		 2nnkB-3kf3A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		5 / 11 ASP A 287
GLY A 289
ASP A 291
ILE A 485
PRO A 355
 None
None
None
None
NAG  A5001 ( 4.9A)
 0.89A 2nnpA-3kf3A:
undetectable		 2nnpA-3kf3A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_2
(PROTEASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		5 / 12 ASP A 287
GLY A 289
ASP A 291
ILE A 485
PRO A 355
 None
None
None
None
NAG  A5001 ( 4.9A)
 0.89A 2o4kB-3kf3A:
undetectable		 2o4kB-3kf3A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		5 / 12 ASP A 287
GLY A 289
ASP A 291
ILE A 485
PRO A 355
 None
None
None
None
NAG  A5001 ( 4.9A)
 0.92A 2o4sA-3kf3A:
undetectable		 2o4sA-3kf3A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_2
(PROTEASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		5 / 12 ASP A 287
GLY A 289
ASP A 291
ILE A 485
PRO A 355
 None
None
None
None
NAG  A5001 ( 4.9A)
 0.92A 2o4sB-3kf3A:
undetectable		 2o4sB-3kf3A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		5 / 12 ASP A 287
GLY A 289
ASP A 291
ILE A 485
PRO A 355
 None
None
None
None
NAG  A5001 ( 4.9A)
 0.88A 2q5kB-3kf3A:
undetectable		 2q5kB-3kf3A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		5 / 12 ASP A 287
GLY A 289
ASP A 291
ILE A 485
PRO A 355
 None
None
None
None
NAG  A5001 ( 4.9A)
 0.88A 2q63A-3kf3A:
undetectable		 2q63A-3kf3A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		5 / 12 ASP A 287
GLY A 289
ASP A 291
ILE A 485
PRO A 355
 None
None
None
None
NAG  A5001 ( 4.9A)
 0.86A 2q64A-3kf3A:
undetectable		 2q64A-3kf3A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		5 / 9 ILE A 413
GLY A 479
ILE A 480
PRO A 509
ILE A 427
 None
 1.12A 2r5qA-3kf3A:
undetectable		 2r5qA-3kf3A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_2
(PROTEASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		5 / 11 ASP A 287
GLY A 289
ASP A 291
ILE A 485
PRO A 355
 None
None
None
None
NAG  A5001 ( 4.9A)
 0.77A 2r5qB-3kf3A:
undetectable		 2r5qB-3kf3A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		5 / 9 ILE A 413
GLY A 479
ILE A 480
PRO A 509
ILE A 427
 None
 1.13A 2r5qC-3kf3A:
undetectable		 2r5qC-3kf3A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_2
(PROTEASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		5 / 10 ASP A 287
GLY A 289
ASP A 291
ILE A 485
PRO A 355
 None
None
None
None
NAG  A5001 ( 4.9A)
 0.76A 2r5qD-3kf3A:
undetectable		 2r5qD-3kf3A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 5 PHE A 183
SER A 113
PHE A 276
ILE A 138
 None
 1.24A 2v0mD-3kf3A:
undetectable		 2v0mD-3kf3A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		3 / 3 PRO A  43
GLY A  46
TYR A  69
 None
 0.69A 2vouB-3kf3A:
undetectable		 2vouB-3kf3A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		3 / 3 PRO A  43
GLY A  46
TYR A  69
 None
 0.68A 2vouC-3kf3A:
undetectable		 2vouC-3kf3A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 7 MET A  48
ALA A 311
ALA A 309
LEU A  54
 None
 0.96A 2wx2A-3kf3A:
undetectable		 2wx2A-3kf3A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 5 GLN A  68
PHE A  67
LEU A 308
PHE A 298
 FRU  A 600 (-4.0A)
None
None
None
 1.15A 3ablC-3kf3A:
undetectable
3ablJ-3kf3A:
undetectable		 3ablC-3kf3A:
19.12
3ablJ-3kf3A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_1
(HIV-1 PROTEASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		5 / 12 ASP A 287
GLY A 289
ASP A 291
ILE A 485
PRO A 355
 None
None
None
None
NAG  A5001 ( 4.9A)
 0.81A 3d1xA-3kf3A:
undetectable		 3d1xA-3kf3A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_1
(HIV-1 PROTEASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		5 / 12 ASP A 287
GLY A 289
ASP A 291
ILE A 485
PRO A 355
 None
None
None
None
NAG  A5001 ( 4.9A)
 0.86A 3d1yA-3kf3A:
undetectable		 3d1yA-3kf3A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 8 ASP A 287
GLY A 289
ASP A 291
PRO A 355
 None
None
None
NAG  A5001 ( 4.9A)
 0.61A 3el0A-3kf3A:
undetectable		 3el0A-3kf3A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		5 / 12 ASP A 287
GLY A 289
ASP A 291
ILE A 485
PRO A 355
 None
None
None
None
NAG  A5001 ( 4.9A)
 0.92A 3el4A-3kf3A:
undetectable		 3el4A-3kf3A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		5 / 10 ASP A 287
GLY A 289
ASP A 291
ILE A 485
PRO A 355
 None
None
None
None
NAG  A5001 ( 4.9A)
 1.01A 3el9B-3kf3A:
undetectable		 3el9B-3kf3A:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 8 MET A  48
ALA A 311
ALA A 309
LEU A  54
 None
 0.95A 3khmA-3kf3A:
undetectable		 3khmA-3kf3A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 7 GLY A 112
PHE A 276
PHE A 271
PHE A 183
 None
 1.10A 3ko0L-3kf3A:
undetectable
3ko0N-3kf3A:
undetectable		 3ko0L-3kf3A:
10.78
3ko0N-3kf3A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		6 / 10 ASP A 412
ILE A 413
GLY A 479
ILE A 480
PRO A 509
ILE A 427
 None
 1.44A 3nu6A-3kf3A:
undetectable		 3nu6A-3kf3A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		5 / 12 ASP A 287
GLY A 289
ASP A 291
ILE A 485
PRO A 355
 None
None
None
None
NAG  A5001 ( 4.9A)
 0.97A 3oxxC-3kf3A:
undetectable		 3oxxC-3kf3A:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		5 / 9 ASP A 412
ILE A 429
GLY A 430
VAL A 481
GLY A 479
 None
 1.42A 4acaB-3kf3A:
undetectable
4acaC-3kf3A:
undetectable		 4acaB-3kf3A:
23.99
4acaC-3kf3A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 9 TYR A  66
PHE A  55
PHE A 161
ILE A 138
 None
 1.33A 4jvlA-3kf3A:
undetectable		 4jvlA-3kf3A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 8 PHE A 502
ARG A 442
ALA A 317
TYR A 316
 None
 1.11A 4lv9A-3kf3A:
undetectable
4lv9B-3kf3A:
undetectable		 4lv9A-3kf3A:
21.13
4lv9B-3kf3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		5 / 11 ASP A 287
GLY A 289
ASP A 291
ILE A 485
PRO A 355
 None
None
None
None
NAG  A5001 ( 4.9A)
 0.95A 4njvC-3kf3A:
undetectable		 4njvC-3kf3A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 7 GLU A 487
TYR A 335
LEU A 351
TYR A 489
 None
 1.11A 4twdF-3kf3A:
undetectable
4twdJ-3kf3A:
undetectable		 4twdF-3kf3A:
20.63
4twdJ-3kf3A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 6 LEU A 477
LEU A 463
PHE A 438
ILE A 440
 None
 1.17A 4y4dA-3kf3A:
undetectable		 4y4dA-3kf3A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		5 / 8 ILE A 413
GLY A 430
PHE A 455
PHE A 502
ASP A 441
 None
 1.44A 5hieD-3kf3A:
undetectable		 5hieD-3kf3A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 8 GLN A 296
ASN A 264
ALA A 252
GLN A 265
 None
 1.16A 5km8A-3kf3A:
undetectable
5km8B-3kf3A:
undetectable		 5km8A-3kf3A:
13.98
5km8B-3kf3A:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 5 TYR A 224
TYR A 225
GLY A 226
GLY A 256
 None
 1.05A 5x7pA-3kf3A:
2.8		 5x7pA-3kf3A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 6 GLN A  68
PHE A  67
LEU A 308
PHE A 298
 FRU  A 600 (-4.0A)
None
None
None
 1.05A 5z84P-3kf3A:
undetectable
5z84W-3kf3A:
undetectable		 5z84P-3kf3A:
19.12
5z84W-3kf3A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 6 GLN A  68
PHE A  67
LEU A 308
PHE A 298
 FRU  A 600 (-4.0A)
None
None
None
 1.07A 5z85P-3kf3A:
undetectable
5z85W-3kf3A:
undetectable		 5z85P-3kf3A:
19.12
5z85W-3kf3A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 6 GLN A  68
PHE A  67
LEU A 308
PHE A 298
 FRU  A 600 (-4.0A)
None
None
None
 1.01A 5z86C-3kf3A:
undetectable
5z86J-3kf3A:
undetectable		 5z86C-3kf3A:
19.12
5z86J-3kf3A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 6 GLN A  68
PHE A  67
LEU A 308
PHE A 298
 FRU  A 600 (-4.0A)
None
None
None
 0.99A 5z86P-3kf3A:
undetectable
5z86W-3kf3A:
undetectable		 5z86P-3kf3A:
19.12
5z86W-3kf3A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 6 GLN A  68
PHE A  67
LEU A 308
PHE A 298
 FRU  A 600 (-4.0A)
None
None
None
 1.07A 5zcoP-3kf3A:
undetectable
5zcoW-3kf3A:
undetectable		 5zcoP-3kf3A:
19.12
5zcoW-3kf3A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 6 GLN A  68
PHE A  67
LEU A 308
PHE A 298
 FRU  A 600 (-4.0A)
None
None
None
 1.01A 5zcpC-3kf3A:
undetectable
5zcpJ-3kf3A:
undetectable		 5zcpC-3kf3A:
19.12
5zcpJ-3kf3A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 6 GLN A  68
PHE A  67
LEU A 308
PHE A 298
 FRU  A 600 (-4.0A)
None
None
None
 1.05A 5zcpP-3kf3A:
undetectable
5zcpW-3kf3A:
undetectable		 5zcpP-3kf3A:
19.12
5zcpW-3kf3A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		5 / 12 ASP A 287
GLY A 289
ASP A 291
ILE A 485
PRO A 355
 None
None
None
None
NAG  A5001 ( 4.9A)
 0.90A 6dj1B-3kf3A:
undetectable		 6dj1B-3kf3A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		5 / 12 ASP A 287
GLY A 289
ASP A 291
ILE A 485
PRO A 355
 None
None
None
None
NAG  A5001 ( 4.9A)
 0.93A 6dj2B-3kf3A:
undetectable		 6dj2B-3kf3A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		5 / 12 VAL A 116
PHE A  55
PHE A 161
HIS A  84
TYR A  66
 None
 1.33A 6mxtA-3kf3A:
undetectable		 6mxtA-3kf3A:
21.64