SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kfu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		4 / 5 LEU F 119
LEU F  99
LEU F 280
GLY F  59
 None
 0.97A 1a4lC-3kfuF:
undetectable		 1a4lC-3kfuF:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		4 / 7 LEU F 280
VAL F 283
LEU F 117
LEU F  99
 None
 0.88A 1cqpA-3kfuF:
undetectable
1cqpB-3kfuF:
undetectable		 1cqpA-3kfuF:
15.00
1cqpB-3kfuF:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		4 / 6 VAL F 368
GLY F 369
ALA F 334
LEU F 335
 None
 0.77A 1e7bB-3kfuF:
undetectable		 1e7bB-3kfuF:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 12 THR E 410
ALA E 413
LEU E 247
LEU E 384
LEU E 447
 None
 1.18A 1eiiA-3kfuE:
undetectable		 1eiiA-3kfuE:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		4 / 8 CYH F  41
VAL F  40
CYH F  24
GLY F  23
 ZN  F 673 (-2.0A)
None
ZN  F 673 (-2.1A)
None
 0.80A 1ekjA-3kfuF:
undetectable
1ekjB-3kfuF:
undetectable		 1ekjA-3kfuF:
20.81
1ekjB-3kfuF:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 8 THR E 109
ALA E 146
GLY E  36
THR E 120
THR E 128
 None
 1.39A 1gtnI-3kfuE:
undetectable
1gtnJ-3kfuE:
undetectable		 1gtnI-3kfuE:
9.27
1gtnJ-3kfuE:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 10 GLY E  36
THR E 120
THR E 128
THR E 109
ALA E 146
 None
 1.41A 1gtnO-3kfuE:
undetectable
1gtnP-3kfuE:
undetectable		 1gtnO-3kfuE:
9.27
1gtnP-3kfuE:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 9 GLY E  36
THR E 120
THR E 128
THR E 109
ALA E 146
 None
 1.44A 1gtnQ-3kfuE:
undetectable
1gtnR-3kfuE:
undetectable		 1gtnQ-3kfuE:
9.27
1gtnR-3kfuE:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GYX_A_BEZA1077_0
(HYPOTHETICAL PROTEIN
YDCE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus;
Thermus
thermophilus) 		4 / 7 ARG F  78
TYR E 182
PRO F 268
SER E 196
 None
 1.47A 1gyxA-3kfuF:
undetectable
1gyxB-3kfuF:
undetectable		 1gyxA-3kfuF:
16.67
1gyxB-3kfuF:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		4 / 8 ASN E 257
LEU E 265
ALA E 268
LEU E 269
 None
 0.76A 1hwiB-3kfuE:
undetectable		 1hwiB-3kfuE:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		4 / 8 ASN E 257
LEU E 265
ALA E 268
LEU E 269
 None
 0.79A 1hwiD-3kfuE:
undetectable		 1hwiD-3kfuE:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		4 / 8 ASN E 257
LEU E 265
ALA E 268
LEU E 269
 None
 0.78A 1hwiC-3kfuE:
undetectable		 1hwiC-3kfuE:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 11 LEU E 287
LEU E 415
ALA E 300
ALA E 298
LEU E 291
 None
 1.38A 1iiuA-3kfuE:
undetectable		 1iiuA-3kfuE:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		4 / 8 GLU E 322
GLY E 325
GLU E 328
ASP E 310
 None
 0.92A 1jg4A-3kfuE:
undetectable		 1jg4A-3kfuE:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 9 GLY E 335
GLY E 115
PHE E 114
GLU E 113
GLY E 117
 None
 1.07A 1jhoA-3kfuE:
undetectable		 1jhoA-3kfuE:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 9 GLY E 335
GLY E 115
PHE E 114
GLU E 113
GLY E 117
 None
 1.06A 1jhrA-3kfuE:
undetectable		 1jhrA-3kfuE:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 9 GLY E 335
GLY E 115
PHE E 114
GLU E 113
GLY E 117
 None
 1.07A 1jhyA-3kfuE:
undetectable		 1jhyA-3kfuE:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus;
Thermus
thermophilus) 		5 / 12 ALA E  92
SER E 186
PHE E 188
GLY F  46
ILE E 191
 None
 1.28A 1kglA-3kfuE:
undetectable		 1kglA-3kfuE:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 12 GLY E 164
VAL E 411
SER E 160
SER E 118
TYR E 295
 None
 1.19A 1kiaD-3kfuE:
undetectable		 1kiaD-3kfuE:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 9 GLY E 335
GLY E 115
PHE E 114
GLU E 113
GLY E 117
 None
 1.03A 1l4nA-3kfuE:
undetectable		 1l4nA-3kfuE:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 9 GLY E 335
GLY E 115
PHE E 114
GLU E 113
GLY E 117
 None
 1.07A 1l5kA-3kfuE:
0.9		 1l5kA-3kfuE:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 9 GLY E 335
GLY E 115
PHE E 114
GLU E 113
GLY E 117
 None
 1.04A 1l5lA-3kfuE:
undetectable		 1l5lA-3kfuE:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 9 GLY E 335
GLY E 115
PHE E 114
GLU E 113
GLY E 117
 None
 1.05A 1l5mA-3kfuE:
0.9		 1l5mA-3kfuE:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 12 GLY E 164
VAL E 411
SER E 160
SER E 118
TYR E 295
 None
 1.17A 1nbhA-3kfuE:
undetectable		 1nbhA-3kfuE:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 12 GLY E 164
VAL E 411
SER E 160
SER E 118
TYR E 295
 None
 1.18A 1nbhC-3kfuE:
undetectable		 1nbhC-3kfuE:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 12 GLY E 164
VAL E 411
SER E 160
SER E 118
TYR E 295
 None
 1.18A 1nbhD-3kfuE:
undetectable		 1nbhD-3kfuE:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 12 LEU E  41
ASN E  42
GLY E 107
VAL E  65
LEU E 153
 None
 1.44A 1nhzA-3kfuE:
undetectable		 1nhzA-3kfuE:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT C
(Thermus
thermophilus;
Thermus
thermophilus) 		3 / 3 CYH F  22
ARG G  63
CYH F  38
 ZN  F 673 (-2.1A)
None
ZN  F 673 (-2.1A)
 1.35A 1p9gA-3kfuF:
undetectable		 1p9gA-3kfuF:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT C
(Thermus
thermophilus;
Thermus
thermophilus) 		3 / 3 CYH F  24
ARG G  63
CYH F  38
 ZN  F 673 (-2.1A)
None
ZN  F 673 (-2.1A)
 1.47A 1p9gA-3kfuF:
undetectable		 1p9gA-3kfuF:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		4 / 8 ASP E 112
GLY E 117
GLY E 140
GLY E 139
 None
 0.59A 1qzzA-3kfuE:
undetectable		 1qzzA-3kfuE:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 12 PHE E 114
GLY E 115
THR E 120
PHE E 126
ALA E  78
 None
 1.22A 1vq1A-3kfuE:
undetectable		 1vq1A-3kfuE:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		4 / 5 PHE F  76
LEU F  99
PHE F  21
MET F  20
 None
 1.29A 1wrkB-3kfuF:
undetectable		 1wrkB-3kfuF:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		5 / 12 LEU F  66
ALA F 168
GLN F 167
LEU F 163
LEU F 107
 None
 1.29A 1ya3B-3kfuF:
undetectable		 1ya3B-3kfuF:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3kfu NON-DISCRIMINATING
AND ARCHAEAL-TYPE
ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 5 LEU A 255
GLY A 403
PRO A 124
ALA A 123
 None
 0.83A 2aohA-3kfuA:
undetectable		 2aohA-3kfuA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 12 LEU E 213
LEU E  98
LYS E  99
ALA E  64
ALA E 148
 None
 1.14A 2br4E-3kfuE:
undetectable		 2br4E-3kfuE:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		4 / 8 ALA E 146
ALA E 154
ARG E  27
LEU E 106
 None
 0.82A 2bxmA-3kfuE:
undetectable		 2bxmA-3kfuE:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 10 PHE E 394
GLY E  36
GLY E 144
ALA E 147
ALA E 148
 None
 1.10A 2ej3B-3kfuE:
undetectable		 2ej3B-3kfuE:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		4 / 6 TRP E 284
GLU E 252
PRO E 288
ALA E 290
 None
 1.28A 2ejfB-3kfuE:
undetectable		 2ejfB-3kfuE:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		4 / 7 TRP E 284
GLU E 252
PRO E 288
ALA E 290
 None
 1.35A 2ejgA-3kfuE:
undetectable		 2ejgA-3kfuE:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		4 / 6 TYR E 295
GLY E 117
TYR E 294
ASP E 112
 None
 1.27A 2g72A-3kfuE:
undetectable		 2g72A-3kfuE:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 11 LEU E 158
ASP E 198
GLY E 183
ALA E  94
ILE E 200
 None
 1.15A 2idwA-3kfuE:
undetectable		 2idwA-3kfuE:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 12 ALA E  94
ASP E 198
PRO E 180
GLY E 183
LEU E 228
 None
 1.28A 2nv4B-3kfuE:
undetectable		 2nv4B-3kfuE:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		5 / 12 LEU F  66
ALA F 168
GLN F 167
LEU F 163
LEU F 107
 None
 1.33A 2oaxB-3kfuF:
undetectable		 2oaxB-3kfuF:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		5 / 12 LEU F  66
ALA F 168
GLN F 167
LEU F 163
LEU F 107
 None
 1.29A 2oaxD-3kfuF:
undetectable		 2oaxD-3kfuF:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		5 / 12 LEU F  66
ALA F 168
GLN F 167
LEU F 163
LEU F 107
 None
 1.26A 2oaxE-3kfuF:
undetectable		 2oaxE-3kfuF:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus;
Thermus
thermophilus) 		4 / 8 LEU E 111
LEU E 306
PRO E  88
GLY F  46
 None
 0.86A 2po5A-3kfuE:
undetectable		 2po5A-3kfuE:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus;
Thermus
thermophilus) 		4 / 8 LEU E 111
LEU E 306
PRO E  88
GLY F  46
 None
 0.88A 2po5B-3kfuE:
undetectable		 2po5B-3kfuE:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT C
(Thermus
thermophilus;
Thermus
thermophilus) 		4 / 5 ILE G  35
ARG E 341
ARG E 340
ASP G  31
 None
 1.40A 2rhmB-3kfuG:
undetectable		 2rhmB-3kfuG:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		4 / 6 PHE E 423
LEU E 247
ALA E 450
LEU E 447
 None
 0.69A 2vcvB-3kfuE:
undetectable		 2vcvB-3kfuE:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		4 / 6 PHE E 423
LEU E 247
ALA E 450
LEU E 447
 None
 0.66A 2vcvK-3kfuE:
undetectable		 2vcvK-3kfuE:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		4 / 8 PHE E 423
LEU E 247
ALA E 450
LEU E 447
 None
 0.66A 2vcvP-3kfuE:
undetectable		 2vcvP-3kfuE:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		3 / 3 TYR F 298
GLU F 289
THR F 172
 None
 1.01A 2y7hB-3kfuF:
undetectable		 2y7hB-3kfuF:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		4 / 8 ASP E 229
ARG E  97
GLY E 219
PRO E 231
 None
 0.96A 2ys6A-3kfuE:
undetectable		 2ys6A-3kfuE:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		4 / 7 GLU F 146
ARG F 116
GLU F 120
SER F  93
 MG  F 674 (-3.1A)
None
MG  F 674 (-2.0A)
None
 1.29A 2zt7A-3kfuF:
undetectable		 2zt7A-3kfuF:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		4 / 8 ILE F 166
LEU F 163
ARG F 111
LEU F 153
 None
 0.93A 3abkA-3kfuF:
undetectable
3abkJ-3kfuF:
undetectable		 3abkA-3kfuF:
18.69
3abkJ-3kfuF:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		4 / 7 TYR E 294
GLY E 163
TYR E 182
ARG E 365
 None
 0.94A 3elzA-3kfuE:
undetectable		 3elzA-3kfuE:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 11 GLY E 115
GLY E 117
ASP E 112
THR E 120
ALA E  78
 None
 1.10A 3g88A-3kfuE:
undetectable		 3g88A-3kfuE:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 11 GLY E 115
GLY E 117
ASP E 112
THR E 120
ALA E  78
 None
 1.10A 3g88B-3kfuE:
undetectable		 3g88B-3kfuE:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 12 GLY E 115
GLY E 117
ASP E 112
THR E 120
ALA E  78
 None
 1.09A 3g89A-3kfuE:
undetectable		 3g89A-3kfuE:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 11 GLY E 115
GLY E 117
ASP E 112
THR E 120
ALA E  78
 None
 1.10A 3g89B-3kfuE:
undetectable		 3g89B-3kfuE:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 12 GLY E 115
GLY E 117
ASP E 112
THR E 120
ALA E  78
 None
 1.09A 3g8bA-3kfuE:
undetectable		 3g8bA-3kfuE:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		4 / 4 LEU E 435
PRO E 385
LEU E 383
ARG E 273
 None
 1.45A 3hcoA-3kfuE:
undetectable		 3hcoA-3kfuE:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 12 GLU E 301
GLY E 183
ARG E 365
GLY E 163
ARG E 167
 None
 1.35A 3jzjA-3kfuE:
0.1		 3jzjA-3kfuE:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		4 / 8 ASP F 269
SER E 195
PHE F 265
SER E 304
 None
 1.04A 3m0wE-3kfuF:
undetectable
3m0wF-3kfuF:
undetectable
3m0wG-3kfuF:
undetectable
3m0wH-3kfuF:
undetectable		 3m0wE-3kfuF:
10.58
3m0wF-3kfuF:
10.58
3m0wG-3kfuF:
10.58
3m0wH-3kfuF:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 12 GLY E 159
ALA E 157
THR E 109
ILE E 200
VAL E 166
 None
 1.12A 3nvkI-3kfuE:
undetectable		 3nvkI-3kfuE:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT C
(Thermus
thermophilus;
Thermus
thermophilus) 		5 / 12 GLY E 311
GLY E 315
ALA E 329
LEU E 313
PHE G  83
 None
 1.06A 3p2kA-3kfuE:
undetectable		 3p2kA-3kfuE:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT C
(Thermus
thermophilus) 		5 / 9 ASP F 136
THR F  35
ASN F  34
GLY G  81
ASP G  80
 None
 1.08A 3sfuA-3kfuF:
undetectable		 3sfuA-3kfuF:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		3 / 3 PHE F 371
LYS F 382
SER F 383
 None
G  L  18 ( 3.5A)
None
 1.38A 3tyeB-3kfuF:
undetectable		 3tyeB-3kfuF:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		4 / 4 SER E 303
ASP E 198
ASP E 161
ALA E 298
 None
 1.32A 3uj6A-3kfuE:
undetectable		 3uj6A-3kfuE:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		5 / 12 LEU F 209
VAL F 215
SER F 214
ARG F 217
VAL F 191
 None
 1.49A 3vt7A-3kfuF:
undetectable		 3vt7A-3kfuF:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		4 / 6 HIS F  11
ASP F 188
ASN F 210
GLU F 245
 MG  F 674 (-3.5A)
None
G  L  73 ( 3.8A)
G  L  73 ( 4.9A)
 1.26A 3vywA-3kfuF:
undetectable		 3vywA-3kfuF:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT C
(Thermus
thermophilus;
Thermus
thermophilus) 		5 / 12 GLY E 163
ASP E 407
VAL G  39
TYR E 193
LEU E 415
 None
 1.07A 4a81A-3kfuE:
undetectable		 4a81A-3kfuE:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		4 / 4 GLU E 301
ASP E 198
ARG E 308
THR E 162
 None
 1.26A 4ej1A-3kfuE:
0.3		 4ej1A-3kfuE:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 3kfu NON-DISCRIMINATING
AND ARCHAEAL-TYPE
ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 8 VAL A 314
LEU A 279
HIS A 272
TYR A 317
 None
 1.07A 4f5zA-3kfuA:
undetectable		 4f5zA-3kfuA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 9 GLN E 436
LEU E 383
VAL E 249
VAL E 261
LEU E 265
 None
 1.02A 4g1bC-3kfuE:
undetectable		 4g1bC-3kfuE:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_B_1FLB201_1
(TRANSTHYRETIN)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT C
(Thermus
thermophilus) 		4 / 4 LYS G  17
ALA G  16
SER E 304
THR E 346
 None
 1.48A 4i89B-3kfuG:
undetectable		 4i89B-3kfuG:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 3kfu NON-DISCRIMINATING
AND ARCHAEAL-TYPE
ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 5 PHE A 380
TYR A 376
THR A 326
PHE A 324
 None
 1.13A 4jx1E-3kfuA:
undetectable		 4jx1E-3kfuA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ8_A_ASDA602_1
(CYTOCHROME P450 19A1)		 3kfu NON-DISCRIMINATING
AND ARCHAEAL-TYPE
ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 10 ARG A 133
ILE A 392
ALA A 394
THR A 398
VAL A 127
 None
 1.35A 4kq8A-3kfuA:
undetectable		 4kq8A-3kfuA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 9 GLY E 335
GLY E 115
PHE E 114
GLU E 113
GLY E 117
 None
 1.05A 4kqiA-3kfuE:
undetectable		 4kqiA-3kfuE:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		4 / 6 ARG F 353
GLU F 182
GLU F 181
SER F 179
 None
None
U  L   1 ( 3.2A)
None
 1.36A 4kr3A-3kfuF:
1.8		 4kr3A-3kfuF:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		4 / 6 GLU F 146
ARG F 116
GLU F 120
SER F  93
 MG  F 674 (-3.1A)
None
MG  F 674 (-2.0A)
None
 1.21A 4kr3A-3kfuF:
1.8		 4kr3A-3kfuF:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		5 / 12 LEU F 169
LEU F 280
LEU F 287
ALA F  63
LEU F  66
 None
 1.22A 4m11A-3kfuF:
undetectable		 4m11A-3kfuF:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 9 VAL E  65
ALA E  64
GLY E  73
SER E  40
GLY E 107
 None
 1.33A 4mm5A-3kfuE:
undetectable		 4mm5A-3kfuE:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 12 LEU E 106
GLY E 143
GLY E 144
ALA E  64
GLY E  79
 None
 0.95A 4n09B-3kfuE:
undetectable		 4n09B-3kfuE:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 12 LEU E 106
GLY E 143
GLY E 144
ALA E  64
GLY E  79
 None
 0.96A 4n09D-3kfuE:
undetectable		 4n09D-3kfuE:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT C
(Thermus
thermophilus) 		5 / 10 LEU F  64
LEU F 280
VAL F  56
LEU G  57
LEU F  74
 None
 1.20A 4po0A-3kfuF:
2.1		 4po0A-3kfuF:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 3kfu NON-DISCRIMINATING
AND ARCHAEAL-TYPE
ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 GLU A 220
ARG A 322
GLY A 349
GLY A 389
 None
 0.77A 4rdxA-3kfuA:
10.7		 4rdxA-3kfuA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3kfu NON-DISCRIMINATING
AND ARCHAEAL-TYPE
ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 270
GLU A 293
GLY A 300
ALA A 303
ARG A 396
 None
 1.16A 4retA-3kfuA:
undetectable		 4retA-3kfuA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3kfu NON-DISCRIMINATING
AND ARCHAEAL-TYPE
ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 270
GLU A 293
GLY A 300
ALA A 303
ARG A 396
 None
 1.16A 4retC-3kfuA:
undetectable		 4retC-3kfuA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 10 ASP E 407
ALA E 391
SER E 118
SER E 119
GLY E 139
 None
 1.36A 4xp1A-3kfuE:
undetectable		 4xp1A-3kfuE:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		4 / 7 ILE F 166
LEU F 163
ARG F 111
LEU F 153
 None
 0.79A 5b1aA-3kfuF:
undetectable
5b1aJ-3kfuF:
undetectable		 5b1aA-3kfuF:
18.69
5b1aJ-3kfuF:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		4 / 7 ILE F 166
LEU F 163
ARG F 111
LEU F 153
 None
 0.91A 5b1bA-3kfuF:
undetectable
5b1bJ-3kfuF:
undetectable		 5b1bA-3kfuF:
18.69
5b1bJ-3kfuF:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		4 / 7 ILE F 166
LEU F 163
ARG F 111
LEU F 153
 None
 0.81A 5b3sA-3kfuF:
undetectable
5b3sJ-3kfuF:
undetectable		 5b3sA-3kfuF:
18.69
5b3sJ-3kfuF:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3kfu NON-DISCRIMINATING
AND ARCHAEAL-TYPE
ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 6 PHE A 341
SER A 309
LEU A 312
LEU A 339
 None
 1.12A 5dzke-3kfuA:
undetectable
5dzks-3kfuA:
undetectable		 5dzke-3kfuA:
17.87
5dzks-3kfuA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 9 GLY E  60
ALA E  23
VAL E  20
GLU E  47
ILE E   6
 None
 1.34A 5i3cA-3kfuE:
undetectable		 5i3cA-3kfuE:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 12 TYR E  90
TYR E 314
LEU E  83
ILE E 191
GLY F  46
 None
 1.24A 5ifuA-3kfuE:
undetectable		 5ifuA-3kfuE:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		5 / 9 TYR E  90
TYR E 314
LEU E  83
ILE E 191
GLY F  46
 None
 1.35A 5ifuB-3kfuE:
undetectable		 5ifuB-3kfuE:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		3 / 3 VAL E 250
SER E 283
TRP E 284
 None
 0.87A 5jwaA-3kfuE:
undetectable		 5jwaA-3kfuE:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3kfu NON-DISCRIMINATING
AND ARCHAEAL-TYPE
ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 LEU A 139
ILE A 346
THR A 347
MET A 241
 None
 1.43A 5ljcA-3kfuA:
undetectable		 5ljcA-3kfuA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		4 / 6 GLU E 113
PHE E  86
THR E  76
PHE E 334
 None
 1.39A 5lrbA-3kfuE:
undetectable		 5lrbA-3kfuE:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		4 / 5 THR F  37
ASN F 138
ASP F 136
LEU F 137
 None
 1.33A 5m0iB-3kfuF:
undetectable		 5m0iB-3kfuF:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		6 / 11 LEU F  64
GLY F  67
GLY F 103
LEU F  60
LEU F  99
VAL F  70
 None
 1.44A 5twjD-3kfuF:
undetectable		 5twjD-3kfuF:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 3kfu NON-DISCRIMINATING
AND ARCHAEAL-TYPE
ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LYS A 183
GLU A 220
LEU A 139
LEU A 237
ILE A 392
 None
 0.84A 5v0vA-3kfuA:
undetectable		 5v0vA-3kfuA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 3kfu NON-DISCRIMINATING
AND ARCHAEAL-TYPE
ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LYS A 183
GLU A 220
LEU A 237
ILE A 392
ALA A 391
 None
 1.20A 5v0vA-3kfuA:
undetectable		 5v0vA-3kfuA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		4 / 7 ILE F 166
LEU F 163
ARG F 111
LEU F 153
 None
 0.86A 5xdqA-3kfuF:
undetectable
5xdqJ-3kfuF:
undetectable		 5xdqA-3kfuF:
18.69
5xdqJ-3kfuF:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		4 / 7 ILE F 166
LEU F 163
ARG F 111
LEU F 153
 None
 0.88A 5xdqN-3kfuF:
undetectable
5xdqW-3kfuF:
undetectable		 5xdqN-3kfuF:
18.69
5xdqW-3kfuF:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		4 / 7 ILE F 166
LEU F 163
ARG F 111
LEU F 153
 None
 0.97A 5xdxA-3kfuF:
undetectable
5xdxJ-3kfuF:
undetectable		 5xdxA-3kfuF:
18.69
5xdxJ-3kfuF:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		4 / 8 GLY E 140
GLN E 168
ALA E 171
PHE E 172
 None
 0.98A 5xu8A-3kfuE:
undetectable		 5xu8A-3kfuE:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		4 / 8 ILE F 166
LEU F 163
ARG F 111
LEU F 153
 None
 0.83A 5zcoA-3kfuF:
undetectable
5zcoJ-3kfuF:
undetectable		 5zcoA-3kfuF:
18.69
5zcoJ-3kfuF:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		4 / 7 ILE F 166
LEU F 163
ARG F 111
LEU F 153
 None
 0.83A 5zcpA-3kfuF:
undetectable
5zcpJ-3kfuF:
undetectable		 5zcpA-3kfuF:
18.69
5zcpJ-3kfuF:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		4 / 7 ILE F 166
LEU F 163
ARG F 111
LEU F 153
 None
 0.74A 5zcqA-3kfuF:
undetectable
5zcqJ-3kfuF:
undetectable		 5zcqA-3kfuF:
18.69
5zcqJ-3kfuF:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		4 / 8 ILE F 166
LEU F 163
ARG F 111
LEU F 153
 None
 0.95A 5zcqN-3kfuF:
undetectable
5zcqW-3kfuF:
undetectable		 5zcqN-3kfuF:
18.69
5zcqW-3kfuF:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		4 / 4 GLY E 417
ARG E 167
ASN E 414
LEU E 418
 None
 1.16A 6b58A-3kfuE:
undetectable		 6b58A-3kfuE:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		3 / 3 GLY E  73
THR E  71
GLU E  91
 None
 0.64A 6b58A-3kfuE:
undetectable		 6b58A-3kfuE:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 3kfu NON-DISCRIMINATING
AND ARCHAEAL-TYPE
ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		3 / 3 TYR A 317
ALA A 275
LEU A 291
 None
 0.75A 6d9kF-3kfuA:
undetectable		 6d9kF-3kfuA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		3 / 3 SER E 141
SER E 165
ALA E 192
 None
 0.59A 6dwnC-3kfuE:
undetectable		 6dwnC-3kfuE:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		3 / 3 SER E 141
SER E 165
ALA E 194
 None
 0.73A 6dwnC-3kfuE:
undetectable		 6dwnC-3kfuE:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermus
thermophilus) 		4 / 6 LEU E 418
THR E 416
GLY E 412
ARG E 167
 None
 1.08A 6gtqB-3kfuE:
undetectable
6gtqD-3kfuE:
undetectable		 6gtqB-3kfuE:
18.03
6gtqD-3kfuE:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 3kfu NON-DISCRIMINATING
AND ARCHAEAL-TYPE
ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 6 ARG A 136
ALA A 394
THR A 398
ALA A 130
 None
 1.02A 6ma6A-3kfuA:
undetectable		 6ma6A-3kfuA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		4 / 4 ASP F 152
ILE F   6
PRO F 156
LEU F 153
 None
 1.33A 6mkeB-3kfuF:
undetectable		 6mkeB-3kfuF:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermus
thermophilus) 		4 / 4 ASP F 152
ILE F   6
PRO F 156
LEU F 153
 None
 1.35A 6mkeA-3kfuF:
undetectable		 6mkeA-3kfuF:
12.21