SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kfv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 3kfv TIGHT JUNCTION
PROTEIN ZO-3
(Homo
sapiens) 		4 / 7 TYR A 706
TRP A 783
HIS A 517
TYR A 493
 None
 1.30A 1mxgA-3kfvA:
undetectable		 1mxgA-3kfvA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 3kfv TIGHT JUNCTION
PROTEIN ZO-3
(Homo
sapiens) 		4 / 6 PRO A 634
PHE A 753
LEU A 752
ILE A 697
 None
 1.20A 1sbrA-3kfvA:
undetectable
1sbrB-3kfvA:
undetectable		 1sbrA-3kfvA:
20.36
1sbrB-3kfvA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SS4_A_ACTA411_0
(GLYOXALASE FAMILY
PROTEIN)		 3kfv TIGHT JUNCTION
PROTEIN ZO-3
(Homo
sapiens) 		4 / 5 VAL A 709
THR A 754
GLN A 777
ILE A 782
 None
 1.13A 1ss4A-3kfvA:
undetectable		 1ss4A-3kfvA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 3kfv TIGHT JUNCTION
PROTEIN ZO-3
(Homo
sapiens) 		5 / 12 ILE A 708
ALA A 755
LYS A 771
LEU A 649
VAL A 635
 None
 1.18A 3ix9B-3kfvA:
2.8		 3ix9B-3kfvA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3kfv TIGHT JUNCTION
PROTEIN ZO-3
(Homo
sapiens) 		4 / 7 ALA A 719
PRO A 718
TYR A 739
ARG A 736
 None
 0.96A 3twpB-3kfvA:
undetectable		 3twpB-3kfvA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3kfv TIGHT JUNCTION
PROTEIN ZO-3
(Homo
sapiens) 		4 / 7 ALA A 719
PRO A 718
TYR A 739
ARG A 736
 None
 0.95A 3twpC-3kfvA:
undetectable		 3twpC-3kfvA:
24.75