SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kg7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 3kg7 CURH
(Lyngbya
majuscula) 		5 / 12 PHE A1174
LEU A1197
ALA A1176
LEU A1113
ILE A1135
 None
 1.13A 1crbA-3kg7A:
2.7		 1crbA-3kg7A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 3kg7 CURH
(Lyngbya
majuscula) 		5 / 11 LEU A1198
GLY A1206
ILE A1195
PRO A1143
LEU A1075
 None
 1.08A 1p91A-3kg7A:
undetectable		 1p91A-3kg7A:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3kg7 CURH
(Lyngbya
majuscula) 		4 / 7 ASP A 975
THR A 976
TYR A 974
HIS A1049
 None
 1.50A 2dyrA-3kg7A:
undetectable
2dyrC-3kg7A:
undetectable		 2dyrA-3kg7A:
20.23
2dyrC-3kg7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CHDA1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3kg7 CURH
(Lyngbya
majuscula) 		4 / 7 ASP A 975
THR A 976
TYR A 974
HIS A1049
 None
 1.48A 2y69A-3kg7A:
undetectable
2y69C-3kg7A:
undetectable		 2y69A-3kg7A:
20.23
2y69C-3kg7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3kg7 CURH
(Lyngbya
majuscula) 		4 / 7 ILE A1135
GLY A 981
VAL A 998
LEU A 941
 None
 0.90A 3elzA-3kg7A:
2.0		 3elzA-3kg7A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kg7 CURH
(Lyngbya
majuscula) 		5 / 12 VAL A 982
ALA A 986
LEU A 941
LEU A1098
ARG A1140
 None
 1.06A 4eckB-3kg7A:
undetectable		 4eckB-3kg7A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 3kg7 CURH
(Lyngbya
majuscula) 		4 / 8 ARG A1191
GLY A1210
PRO A1143
THR A1142
 None
 0.76A 4eyrB-3kg7A:
undetectable		 4eyrB-3kg7A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3kg7 CURH
(Lyngbya
majuscula) 		5 / 12 LEU A1121
VAL A1133
PHE A1174
LEU A 989
THR A1170
 None
 1.40A 4iaqA-3kg7A:
undetectable		 4iaqA-3kg7A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 3kg7 CURH
(Lyngbya
majuscula) 		4 / 4 VAL A1178
THR A1110
GLU A1180
GLU A1109
 None
 1.34A 4l78A-3kg7A:
undetectable		 4l78A-3kg7A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 3kg7 CURH
(Lyngbya
majuscula) 		3 / 3 ASP A1199
TRP A1105
SER A1065
 None
 0.94A 4lrhA-3kg7A:
undetectable		 4lrhA-3kg7A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 3kg7 CURH
(Lyngbya
majuscula) 		4 / 5 HIS A 965
PHE A1123
LEU A 941
PRO A1132
 None
 1.43A 4o8zA-3kg7A:
undetectable		 4o8zA-3kg7A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 3kg7 CURH
(Lyngbya
majuscula) 		5 / 10 LEU A1121
LEU A1125
LEU A1166
LEU A 989
VAL A 994
 None
 1.20A 4po0A-3kg7A:
undetectable		 4po0A-3kg7A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 3kg7 CURH
(Lyngbya
majuscula) 		4 / 6 THR A1080
ALA A1104
LEU A1112
SER A1111
 None
 1.02A 4pwjA-3kg7A:
undetectable		 4pwjA-3kg7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 3kg7 CURH
(Lyngbya
majuscula) 		5 / 11 ALA A1100
ALA A1137
LEU A1134
LEU A1125
HIS A1131
 None
 1.26A 5eb5A-3kg7A:
undetectable		 5eb5A-3kg7A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 3kg7 CURH
(Lyngbya
majuscula) 		4 / 8 ILE A1135
VAL A 982
THR A1139
ILE A1195
 None
 0.93A 5mzrE-3kg7A:
undetectable		 5mzrE-3kg7A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3kg7 CURH
(Lyngbya
majuscula) 		5 / 11 LEU A1078
LEU A1083
ARG A1102
GLU A1114
ALA A1104
 None
 0.99A 5o96G-3kg7A:
undetectable		 5o96G-3kg7A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 3kg7 CURH
(Lyngbya
majuscula) 		4 / 8 LEU A1020
HIS A1049
LEU A 941
ILE A 979
 None
 0.97A 5v0vA-3kg7A:
undetectable		 5v0vA-3kg7A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3kg7 CURH
(Lyngbya
majuscula) 		5 / 12 ALA A 997
ASN A1057
GLY A1029
ALA A1025
LEU A1022
 None
 1.28A 5x23A-3kg7A:
undetectable		 5x23A-3kg7A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3kg7 CURH
(Lyngbya
majuscula) 		5 / 10 LEU A1166
THR A1165
ILE A1195
ILE A1135
ILE A 985
 None
 1.00A 6ebpD-3kg7A:
undetectable		 6ebpD-3kg7A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3kg7 CURH
(Lyngbya
majuscula) 		5 / 11 LEU A1166
THR A1165
ILE A1195
ILE A1135
ILE A 985
 None
 1.00A 6ebzA-3kg7A:
undetectable		 6ebzA-3kg7A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3kg7 CURH
(Lyngbya
majuscula) 		5 / 11 LEU A1166
THR A1165
ILE A1195
ILE A1135
ILE A 985
 None
 1.02A 6ebzB-3kg7A:
undetectable		 6ebzB-3kg7A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3kg7 CURH
(Lyngbya
majuscula) 		5 / 11 LEU A1166
THR A1165
ILE A1195
ILE A1135
ILE A 985
 None
 0.99A 6ebzC-3kg7A:
undetectable		 6ebzC-3kg7A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3kg7 CURH
(Lyngbya
majuscula) 		5 / 11 LEU A1166
THR A1165
ILE A1195
ILE A1135
ILE A 985
 None
 1.01A 6ebzD-3kg7A:
undetectable		 6ebzD-3kg7A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 3kg7 CURH
(Lyngbya
majuscula) 		5 / 12 LEU A 942
LEU A 941
ILE A1135
SER A 983
ALA A 986
 None
 1.27A 6n91B-3kg7A:
undetectable		 6n91B-3kg7A:
18.29