SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kgw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 3kgw ALANINE-GLYOXYLATE
AMINOTRANSFERASE
(Mus
musculus) 		5 / 11 CYH A 309
LEU A 233
HIS A 313
VAL A  89
ILE A 215
 None
 1.37A 1ee2A-3kgwA:
4.0		 1ee2A-3kgwA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 3kgw ALANINE-GLYOXYLATE
AMINOTRANSFERASE
(Mus
musculus) 		4 / 8 MET A 225
PHE A  90
SER A 209
ILE A 215
 None
 1.10A 1pnlA-3kgwA:
undetectable
1pnlB-3kgwA:
undetectable		 1pnlA-3kgwA:
17.35
1pnlB-3kgwA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 3kgw ALANINE-GLYOXYLATE
AMINOTRANSFERASE
(Mus
musculus) 		3 / 3 TRP A 310
VAL A 213
PRO A 214
 None
 1.00A 1rg1A-3kgwA:
undetectable		 1rg1A-3kgwA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 3kgw ALANINE-GLYOXYLATE
AMINOTRANSFERASE
(Mus
musculus) 		3 / 3 TRP A 310
VAL A 213
PRO A 214
 None
 0.99A 1rh0A-3kgwA:
undetectable		 1rh0A-3kgwA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3kgw ALANINE-GLYOXYLATE
AMINOTRANSFERASE
(Mus
musculus) 		5 / 11 ALA A 107
ILE A 242
LEU A 201
ILE A 222
PHE A 244
 None
 1.13A 2h42A-3kgwA:
undetectable		 2h42A-3kgwA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 3kgw ALANINE-GLYOXYLATE
AMINOTRANSFERASE
(Mus
musculus) 		4 / 8 SER A 227
LEU A 210
SER A 228
LEU A 233
 None
None
PLP  A 500 (-3.5A)
None
 1.00A 2j2pA-3kgwA:
undetectable
2j2pB-3kgwA:
undetectable		 2j2pA-3kgwA:
19.25
2j2pB-3kgwA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 3kgw ALANINE-GLYOXYLATE
AMINOTRANSFERASE
(Mus
musculus) 		6 / 12 GLY A 387
ALA A 390
ASN A 394
VAL A 395
GLY A 384
ILE A 343
 None
 1.47A 2q64B-3kgwA:
undetectable		 2q64B-3kgwA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 3kgw ALANINE-GLYOXYLATE
AMINOTRANSFERASE
(Mus
musculus) 		4 / 7 ILE A 242
PRO A 287
LEU A 294
ILE A 239
 None
 0.84A 2q83A-3kgwA:
undetectable		 2q83A-3kgwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 3kgw ALANINE-GLYOXYLATE
AMINOTRANSFERASE
(Mus
musculus) 		4 / 6 ILE A 242
PRO A 287
LEU A 294
ILE A 239
 None
 0.91A 2q83B-3kgwA:
undetectable		 2q83B-3kgwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 3kgw ALANINE-GLYOXYLATE
AMINOTRANSFERASE
(Mus
musculus) 		6 / 12 GLY A 387
ALA A 390
ASN A 394
VAL A 395
GLY A 384
ILE A 343
 None
 1.46A 2qakA-3kgwA:
undetectable		 2qakA-3kgwA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3kgw ALANINE-GLYOXYLATE
AMINOTRANSFERASE
(Mus
musculus) 		4 / 6 MET A 132
PRO A 375
GLY A 374
TRP A 130
 None
None
None
PLP  A 500 (-3.4A)
 1.16A 2y7pA-3kgwA:
undetectable		 2y7pA-3kgwA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 3kgw ALANINE-GLYOXYLATE
AMINOTRANSFERASE
(Mus
musculus) 		4 / 7 LYS A  83
ILE A  86
GLN A  87
LEU A 306
 None
 0.76A 3bjwB-3kgwA:
undetectable		 3bjwB-3kgwA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 3kgw ALANINE-GLYOXYLATE
AMINOTRANSFERASE
(Mus
musculus) 		4 / 7 LYS A  83
ILE A  86
GLN A  87
LEU A 306
 None
 0.91A 3bjwF-3kgwA:
undetectable		 3bjwF-3kgwA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 3kgw ALANINE-GLYOXYLATE
AMINOTRANSFERASE
(Mus
musculus) 		4 / 7 LYS A  83
ILE A  86
GLN A  87
LEU A 306
 None
 0.88A 3bjwH-3kgwA:
undetectable		 3bjwH-3kgwA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3kgw ALANINE-GLYOXYLATE
AMINOTRANSFERASE
(Mus
musculus) 		4 / 5 GLY A 128
ILE A 129
VAL A 176
SER A 181
 None
 1.21A 4d33A-3kgwA:
undetectable		 4d33A-3kgwA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3kgw ALANINE-GLYOXYLATE
AMINOTRANSFERASE
(Mus
musculus) 		4 / 5 GLY A 128
ILE A 129
VAL A 176
SER A 181
 None
 1.19A 4d33B-3kgwA:
undetectable		 4d33B-3kgwA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3kgw ALANINE-GLYOXYLATE
AMINOTRANSFERASE
(Mus
musculus) 		4 / 8 GLY A 125
GLY A 128
VAL A 184
GLU A 179
 None
 0.53A 4fgzB-3kgwA:
3.3		 4fgzB-3kgwA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3kgw ALANINE-GLYOXYLATE
AMINOTRANSFERASE
(Mus
musculus) 		4 / 8 LEU A 115
LEU A  96
ILE A 215
GLN A 220
 None
None
None
EDO  A 507 ( 4.7A)
 1.01A 5ljbA-3kgwA:
undetectable		 5ljbA-3kgwA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 3kgw ALANINE-GLYOXYLATE
AMINOTRANSFERASE
(Mus
musculus) 		4 / 5 THR A 110
ASN A 114
ASP A 265
LEU A 269
 None
 1.32A 5m0iB-3kgwA:
undetectable		 5m0iB-3kgwA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 3kgw ALANINE-GLYOXYLATE
AMINOTRANSFERASE
(Mus
musculus) 		4 / 6 ARG A 382
GLY A  49
SER A 180
THR A 342
 None
None
PLP  A 500 (-2.6A)
None
 1.17A 5ysiA-3kgwA:
undetectable		 5ysiA-3kgwA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 3kgw ALANINE-GLYOXYLATE
AMINOTRANSFERASE
(Mus
musculus) 		5 / 10 PHE A 174
MET A 108
ALA A 111
THR A 267
PHE A 244
 None
 1.23A 6hu9C-3kgwA:
undetectable		 6hu9C-3kgwA:
20.36